Abstract: A pen needle assembly (10) includes a pen needle (12) with a hub body (16) having a needle shield (28) that covers a needle (26) and can be retracted to expose the needle during injection and return to the extended position after use and locked in the extended position. A spring (56) is provided to rotate the needle shield after use to a locked position. A locking member (84) can be provided on the needle shield that cooperates with the hub body (16) to prevent rotation after use. An attachment mechanism (38) for the pen needle provides a sensory indication when a needle-bearing hub body (16) is seated on a pen and limits further rotation of the pen needle relative to the delivery device.

Abstract: A syringe with adjustable penetration depth, comprising a tubular syringe barrel, a plunger positioned within the syringe barrel, a hub bearing a needle and attached to the syringe barrel, a movable collar having an open proximal end received over the hub, a distal end wall having an opening through which the needle protrudes, and a sidewall extending proximally from the distal end wall, the sidewall having an interior surface engaging the hub or syringe barrel, and a retaining feature on the collar engaging the hub or barrel and retaining the collar at a plurality of axial positions. The collar travels with respect to the hub along a path defined by the retaining feature on the interior surface of the sidewall engaging the hub or barrel, exposing a greater length of the needle as the collar travels toward the plunger.

Abstract: A medicament delivery system is disclosed including disposable pen needles (10, 60, 120) each having a stainless steel needle or cannula (12, 62, 122) with a concealed or a very short non-injection end (28, 78, 128) that is not intended to pierce the septum (8) of the drug storage compartment (6) of a medication pen (2), thus reducing the risk of needle stick injuries. Several types of non-metallic interfaces (30, 80, 100) serve as intermediaries between the pen needles (10, 60, 120) and a medication pen (2) and perform the septum-piercing function. These improve the flow of medicament to the needle or cannula (12, 62, 122) due to the larger lumen of the plastic interface (30, 80, 100) that directly feeds medicament to the needle or cannula (12, 62, 122), allowing for even smaller gauge needles for improved patient comfort.

Abstract: A syringe is provided with an assembly received on the distal end for adjusting the penetration depth. In embodiments, the assembly includes a collar attached to the syringe hub which moves with respect to the needle between axial positions depending on the desired needle penetration depth. The adjustable penetration depth syringe is useful in the context of self-administered drugs such as insulin, where a longer length needle is needed to fill a syringe from a vial, but a shorter penetration depth is preferred for administering a subcutaneous injection.

Abstract: A needle-bearing hub for a pen needle is provided with a distal patient-facing side having an enlarged surface for contact with the subject's skin. The enlarged surface is provided with a radius of curvature that increases the likelihood that the needle reaches full injection depth when an injection is performed at an inclined angle with respect to the surface of the skin and with to the desired depth less discomfort to the patient.

Abstract: User-friendly attachment mechanisms for pen needles provide improved handling and ease of use, including locking installation and removal features and sensory feedback when a needle-bearing hub is seated on a pen.

Abstract: The subject invention provides a safety pen needle assembly which includes: a hub; a needle carrier; a needle fixed to the needle carrier; a shield; and, a first engageable locking arrangement for fixing the shield to the needle carrier. Upon a predetermined extent of distal movement of the shield relative to the hub, the first locking arrangement is engaged such that the shield becomes fixed to the needle carrier. Upon further distal movement of the shield relative to the hub beyond the predetermined extent of distal movement, the shield and the needle carrier move in concert together relative to the hub causing a proximal end of the needle to move distally relative to the hub to a retracted state. Advantageously, the subject invention provides a reliable, low-cost safety pen needle assembly which does not require a spring or other biasing element.

Abstract: In a first aspect, a safety pen needle assembly is provided herein which includes a hub and a needle fixed to the hub which extends distally from the hub so as to define an injection length. A first shield is slidable relative to the hub from a first state, in which the shield covers at least a substantial portion of the injection length of the needle, to a second state, in which at least a substantial portion of the injection length of the needle is exposed; and, a second shield is slidable from a first position, in which the shield covers the proximal end of the needle, to a second position, in which the proximal end of the needle is exposed. A biasing element is disposed between the first and second shields configured to simultaneously urge the first shield distally and the second shield proximally.

Abstract: Systems and methods encourage users to rotate injection sites and avoid lipodystrophy. Sleeves and/or lost-tooth gear dials and/or microswitches in or on injection pens or their caps, on vials, and on other portable devices manually adjust an indicator before or after an injection to show a current or next injection site in accordance with a site rotation plan. Injected medicine packaging and related printed indicia encourage site rotation. Optical devices employing optical mouse or projection technology help locate and/or distribute injection sites within a body area. A mobile phone app tracks injections and locations to select next injection site, and can use imaging to locate a target injection site and optionally diagnose lipodystrophic conditions and record them. Tactile and print media educational tools are presented to help users palpate and identify lipos in body areas having injection sites.

Abstract: Some examples provide a non-transitory computer readable medium having instructions executable by a processor of a computing device. The instructions can cause the processor to establish remote access by the computing device to a network-based storage resource, and establish the remote access based on a hardware identifier associated with the computing device. The instructions can cause the processor to generate, at the computing device, a local index for the remote data stored on the network-based storage resource and available to the computing device through the remote access. The instructions can cause the processor to provide, based on the local index, local access to the remote data through a virtual file system at the computing device.

Abstract: User-friendly attachment mechanisms for pen needles provide improved handling and ease of use, including locking installation and removal features and sensory feedback when a needle-bearing hub is seated on a pen. Embodiments include a needle-bearing hub includes a circumferentially oriented flexible tab that engages a radially inward rib on an outer cover to assist in attaching a pen device to the pen needle.

Abstract: A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which the thickness of the membrane is reduced in stepwise fashion, or the pores can be tapered. Nozzles formed comprising pores having such structures permit aerosol generation at lower extrusion pressures, thereby allowing for decreased weight of aerosolization devices, increased efficiency, increased portability and increased battery life. The pore structures also allow for the use of thicker, more easily processed polymeric films in manufacturing while having a thinner, more efficient aerosolization area. The use of decreased extrusion pressures also results in increased uniformity in aerosol generation and improved reliability of other components.

Abstract: The subject invention provides a safety pen needle assembly which includes: a hub; a needle carrier; a needle fixed to the needle carrier; a shield; and, a first engageable locking arrangement for fixing the shield to the needle carrier. Upon a predetermined extent of distal movement of the shield relative to the hub, the first locking arrangement is engaged such that the shield becomes fixed to the needle carrier. Upon further distal movement of the shield relative to the hub beyond the predetermined extent of distal movement, the shield and the needle carrier move in concert together relative to the hub causing a proximal end of the needle to move distally relative to the hub to a retracted state. Advantageously, the subject invention provides a reliable, low-cost safety pen needle assembly which does not require a spring or other biasing element.

Abstract: In a first aspect, a safety pen needle assembly is provided herein which includes a hub and a needle fixed to the hub which extends distally from the hub so as to define an injection length. A first shield is slidable relative to the hub from a first state, in which the shield covers at least a substantial portion of the injection length of the needle, to a second state, in which at least a substantial portion of the injection length of the needle is exposed; and, a second shield is slidable from a first position, in which the shield covers the proximal end of the needle, to a second position, in which the proximal end of the needle is exposed. A biasing element is disposed between the first and second shields configured to simultaneously urge the first shield distally and the second shield proximally.

Abstract: A syringe is provided with an assembly received on the distal end for adjusting the penetration depth. In embodiments, the assembly includes a collar attached to the syringe hub which moves with respect to the needle between axial positions depending on the desired needle penetration depth. The adjustable penetration depth syringe is useful in the context of self-administered drugs such as insulin, where a longer length needle is needed to fill a syringe from a vial, but a shorter penetration depth is preferred for administering a subcutaneous injection.

Abstract: A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which the thickness of the membrane is reduced in stepwise fashion, or the pores can be tapered. Nozzles formed comprising pores having such structures permit aerosol generation at lower extrusion pressures, thereby allowing for decreased weight of aerosolization devices, increased efficiency, increased portability and increased battery life. The pore structures also allow for the use of thicker, more easily processed polymeric films in manufacturing while having a thinner, more efficient aerosolization area. The use of decreased extrusion pressures also results in increased uniformity in aerosol generation and improved reliability of other components.

Abstract: An aerosol generation system having an aerosol generator wherein a liquid formulation is at least partially volatilized in a capillary passage and discharged from the capillary passage to form an aerosol. The aerosol generation system includes a pumping unit adapted to supply a liquid formulation to the aerosol generator; and a fluidic element located between the pumping unit and the capillary passage of the aerosol generator, wherein the fluidic element increases backpressure of the liquid formulation as the liquid formulation enters the capillary passage of the aerosol generator.

Abstract: An aerosol generation system having an aerosol generator wherein a liquid formulation is at least partially volatilized in a capillary passage and discharged from the capillary passage to form an aerosol. The aerosol generation system includes a pumping unit adapted to supply a liquid formulation to the aerosol generator; and a fluidic element located between the pumping unit and the capillary passage of the aerosol generator, wherein the fluidic element increases backpressure of the liquid formulation as the liquid formulation enters the capillary passage of the aerosol generator.