Abstract: A parenteral unit dosage form comprising an aqueous solution of dihydroergotamine or pharmaceutically acceptable salt thereof as a sole active ingredient, one or more pH adjusting agents, and optionally one or more co-solvents, wherein the pH of the aqueous solution is such that it contains substantially lower amount of impurity of Formula I and impurity of Formula II as compared to aqueous solution having a pH of 4.0 or less, when the parenteral unit dosage form is stored at 25° C. and 60% relative humidity for at least three months.

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

Abstract: Techniques for secure sharing of data in computing systems are disclosed herein. In one embodiment, a method includes when exchanging data between the host operating system and the guest operating system, encrypting, at a trusted platform module (TPM) of the host, data to be exchanged with a first key to generate encrypted data. The method also includes transmitting the encrypted data from the host operating system to the guest operating system and decrypting, at the guest operating system, the transmitted encrypted data using a second key previously exchanged between the TPM of the host and a virtual TPM of the guest operating system.

Abstract: Peripheral blood mononuclear cells (PBMCs) can be used in place of DCs when pulsing with antigens, or antigen and adjuvant combination, and then administered to a subject as a vaccine to induce a protective immune response. The PBMC-based vaccine strategy provides a more marked and enduring protective immune response and is also capable of serving as a multi-organism prophylactic vaccine platform. The vaccine platform may be used to screen vaccine and adjuvant combinations and may also be used to allow for adjuvants that are otherwise unsafe for use in humans as the adjuvant may be removed prior to prophylactic administration of the pulsed PBMCs.

Abstract: Techniques for memory assignment for guest operating systems are disclosed herein. In one embodiment, a method includes generating a license blob containing data representing a product key copied from a record of license information in the host storage upon receiving a user request to launch an application in the guest operating system. The method also includes storing the generated license blob in a random memory location accessible by the guest operating system. The guest operating system can then query the license blob for permission to launch the application and launching the application in the guest operating system without having a separate product key for the guest operating system.

Abstract: In various example embodiments, a machine is configured to redirect completion of a transaction to a trusted device. For example, the machine determines that a page involving the transaction is being displayed in a user interface of a first device. The page may be associated with the product or service. The machine identifies an interruption of the displaying of the page in the user interface of the first device. The machine identifies a second device that is trusted by the user. The machine transmits a communication including a notification to the second device. The notification indicates the transaction.

Abstract: Securely storing, installing, or launching applications. A method includes determining a trust characteristic or a license characteristic assigned to an application. When the trust characteristic or the license characteristic meets or exceeds a predetermined trust condition or a predetermined license condition, then the method includes at least one of storing, installing or launching the application in a first, more secure operating system while preventing the application from, being at least one of stored, installed or launched in a second, less secure operating system. When the trust characteristic or the license characteristic does not meet or exceed the predetermined trust condition or the predetermined license condition, then the method includes at least one of storing, installing or launching the application in the second less secure operating system while preventing the application from being at least one of stored, installed or launched in the first, more secure operating system.

Abstract: The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

Abstract: A network service or application can receive dietary goals or conditions for a user or group of users. The network can determine threshold dietary amounts that users can receive over a predetermined time period to satisfy the goals or conditions. The network can monitor user consumption over the predetermined time period by collecting data from heterogeneous data streams (e.g., data associated with different structures, data types, types of data store, sources, processing rates, etc.), processing the data, storing the data using a distributive processing framework, and exposing optimized views into the data to provide smart virtual shopping cart functionality. The network can evaluate user consumption and food items placed into a virtual shopping cart to determine whether purchasing the items satisfy the thresholds, and if not, issue warnings, provide recommendations for substitute food items, and/or take other appropriate actions.

Abstract: In various example embodiments, a machine is configured to redirect completion of a transaction to a trusted device. For example, the machine determines that a page involving the transaction is being displayed in a user interface of a first device. The page may be associated with the product or service. The machine identifies an interruption of the displaying of the page in the user interface of the first device. The machine identifies a second device that is trusted by the user. The machine transmits a communication including a notification to the second device. The notification indicates the transaction.

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

Abstract: A user equipment, radio control node, method and computer program are disclosed. The user equipment is configured to communicate with other devices across a wireless communication network comprising a plurality of radio coverage cells, the user equipment being configured to respond to receipt of a message from the network, the message comprising a wait time, to not transmit a connection request until after expiry of the wait time; wherein the user equipment is configured during the wait time to receive paging requests from the network; and is configured to respond to at least some of the paging requests, the user equipment being configured to select the at least some of the paging requests to respond to in dependence upon paging information received from the network.

Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

Abstract: Provided are novel methods for expressing antigens in a vaccine vector strain, a live oral vaccine designed to prevent clostridium difficile-associated disease and methods for delivering antigens to the mucosal immune system of a subject.

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

Abstract: Systems, methods and media are provided for operating a group purchase event in a networked system. An example method comprises initiating a digital instance of a group purchase event and defining a target balance, identifying a potential contributor list from a social or community group, transmitting an electronic communication to first and second parties on the potential contributor list via an electronic communication pathway, and based on a received response to the electronic communication, authorizing the first and second parties to participate in the group purchase event. One example identifies and presents, in a display of an electronic device, a list of items purchasable at prices less than or equal to a current balance of a money pool, and monitors changes in the current balance. Based on a change in the current balance, the displayed list of items is dynamically updated.

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.