Patents by Inventor Sudha Shenoy

Sudha Shenoy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BETA-ARRESTIN COMPOSITIONS AND ASSOCIATED METHODS
    Publication number: 20230227514
    Abstract: Provided herein are compositions and methods for assessing arrestin-dependent signaling. The provided compositions include fusion proteins comprising arrestin polypeptides that bind strongly to G protein-coupled receptors (GPCRs). In some instances, the fusion proteins may also bind to non-GPCR proteins, such as single transmembrane receptors and non-receptor proteins. Also provided are nucleic acids, vectors, constructs, and host cells that encode or express such fusion proteins. Also provided are methods of using such fusion proteins to assess arrestin trafficking, localization, and other functions including, for example, arrestin-mediated GPCR signaling as well as non-GPCR protein activity or signaling.
    Type: Application
    Filed: March 25, 2021
    Publication date: July 20, 2023
    Applicant: Duke University
    Inventor: Sudha SHENOY
  • METHOD TREATING BREAST CANCER
    Publication number: 20130039929
    Abstract: The present invention relates, in general, to breast cancer and, in particular, to methods of treating breast cancer comprising administering to a subject in need thereof an agent that modulates signal transduction regulated by ?-arrestin (e.g., ?-arrestin 1). The invention further relates to methods of identifying compounds suitable for use in such methods.
    Type: Application
    Filed: April 19, 2011
    Publication date: February 14, 2013
    Inventors: Sudha Shenoy, Mark Dewhirst, Sang-Oh Han
  • Modified trafficking patterns for arrestin and G-protein-coupled receptors via arrestin-ubiquitin chimera
    Patent number: 7615610
    Abstract: The present invention relates to a modified arrestin which includes an arrestin molecule and a ubiquitin molecule. This modified arrestin has an increased affinity for a GPCR, and traffics with the GPCR into endosomes. The present invention further relates to a method of screening compounds and sample solutions for a GPCR agonist, antagonist, inverse agonist, or desensitization active compound. The modified arrestin is useful in the methods of the present invention.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: November 10, 2009
    Assignee: Duke University
    Inventors: Sudha Shenoy, Robert J. Lefkowitz
  • Modified trafficking patterns for arrestin and g-protein-coupled receptors via arrestin-ubiquitin chimera
    Publication number: 20060263828
    Abstract: The present invention relates to a modified arrestin which includes an arrestin molecule and a ubiquitin molecule. This modified arrestin has an increased affinity for a GPCR, and traffics with the GPCR into endosomes. The present invention further relates to a method of screening compounds and sample solutions for a GPCR agonist, antagonist, inverse agonist, or desensitization active compound. The modified arrestin is useful in the methods of the present invention.
    Type: Application
    Filed: January 26, 2004
    Publication date: November 23, 2006
    Inventors: Sudha Shenoy, Robert Lefkowitz