Abstract: The present disclosure provides codon optimized synthetic nucleotide sequences encoding Bacillus thuringiensis (Bt) insecticidal crystal Cry2Ai protein having insecticidal activity against insect pests including, but not limited to insect pests belonging to the order Lepidoptera. The present disclosure also relates to expression of these sequences in plants. The disclosure further provides a DNA construct, a vector, and a host cell comprising the codon optimized synthetic nucleotide sequences of the invention. Also it provides use of the codon optimized synthetic nucleotide sequences for production of insect resistant transgenic plants, and a composition comprising Bacillus thuringiensis comprising the codon optimized synthetic nucleotide sequence of the present invention.

Abstract: Compounds of Formula (I); in salt or zwitterionic form wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Abstract: A frame assembly for holding and orienting a fiber optic member is provided. The assembly comprises tubular means having a bore proportioned to slidingly receive a fiber optic member. The tubular means carries outwardly projecting flange means. U-shaped retainer means is proportioned to loosely receive the tubular means with the flange means being in essential contact with the retainer means. Accordingly, the fiber optic member may be moved with four degrees of freedom within the tubular means to occupy its desired position. Following this, it is affixed in that position by securing the fiber optic member to the tubular means and the flange means to the retainer means. Preferably, laser welding is used for each of the securing steps, since the system does not have to be touched or pushed in any way as the laser welding takes place.