Abstract: A system is presented that includes two data processing systems that are coupled via a network, each data processing system including a reconfigurable processor with a reconfigurable processor memory, a host that is coupled to the reconfigurable processor and that includes a host processor and a host memory that is coupled to the host processor, and a network interface controller (NIC) that is operatively coupled to the reconfigurable processor and to the host processor. The reconfigurable processor of one of the data processing systems is configured to implement a virtual function that uses a virtual address for a memory access operation. An application programming interface (API) in the host processor translates the virtual address into a physical address, and the NIC uses the physical address to initiate a direct memory access operation at the reconfigurable processor memory or the host memory of the other data processing system.