Patents by Inventor SUDHAKAR MANDA

SUDHAKAR MANDA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkylidene phosphonate esters as p-glycoprotein inducers
    Patent number: 10377781
    Abstract: The present invention relates to the alkylidene phosphonate esters of formula I wherein, R1 is selected from a group consisting of hydrogen or alkyl group; R2 is selected from a group consisting of hydrogen, hydroxy, alkyl, alkoxy, nitro, halogen, amino, N-substituted alkylamino; alkyl group is selected from a group consisting of methyl, ethyl and isopropyl; Ar is selected from a group consisting of aryl, substituted aryl, fused aryl, heteroaryl, and substituted heteroaryl. The present invention particularly relates to synthesis and p-glycoprotein induction activity of the alkylidene phosphonate esters. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: August 13, 2019
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Sandip Bharate, Ajay Kumar, Sudhakar Manda, Prashant Joshi, Sonali Bharate, Abubakar Wani, Sadhana Sharma, Ram Vishwakarma
  • N-substituted beta-carbolinium compounds as potent P-glycoprotein inducers
    Patent number: 10072009
    Abstract: The present invention relates to the N-substituted beta-carbolinium compounds of general formula A and formulae I and II wherein, R1 and R2 groups are selected from halogens or trifluoromethyl; R3 group is selected from hydrogen or methyl; Ar is selected from aryl and heteroaryl, X is selected from halogens; and R1 and R2 groups may be attached to any position on ring E. The present invention particularly relates to synthesis and p-glycoprotein induction activity of the N-substituted beta-carbolinium compounds. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: September 11, 2018
    Assignee: Council of Scientific and Industrial Research
    Inventors: Sandip Bharate, Ajay Kumar, Sudhakar Manda, Prashant Joshi, Sonali Bharate, Ram Vishwakarma
  • N-SUBSTITUTED BETA-CARBOLINIUM COMPOUNDS AS POTENT P-GLYCOPROTEIN INDUCERS
    Publication number: 20170334911
    Abstract: The present invention relates to the N-substituted beta-carbolinium compounds of general formula A and formulae I and II wherein, R1 and R2 groups are selected from halogens or trifluoromethyl; R3 group is selected from hydrogen or methyl; Ar is selected from aryl and heteroaryl, X is selected from halogens; and R1 and R2 groups may be attached to any position on ring E. The present invention particularly relates to synthesis and p-glycoprotein induction activity of the N-substituted beta-carbolinium compounds. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease.
    Type: Application
    Filed: October 21, 2015
    Publication date: November 23, 2017
    Inventors: Sandip Bharate, Ajay Kumar, Sudhakar Manda, Prashant Joshi, Sonali Bharate, Ram Vishwakarma
  • ALKYLIDENE PHOSPHONATE ESTERS AS P-GLYCOPROTEIN INDUCERS
    Publication number: 20170275314
    Abstract: The present invention relates to the alkylidene phosphonate esters of formula I wherein, R1 is selected from a group consisting of hydrogen or alkyl group; R2 is selected from a group consisting of hydrogen, hydroxy, alkyl, alkoxy, nitro, halogen, amino, N-substituted alkylamino; alkyl group is selected from a group consisting of methyl, ethyl and isopropyl; Ar is selected from a group consisting of aryl, substituted aryl, fused aryl, heteroaryl, and substituted heteroaryl. The present invention particularly relates to synthesis and p-glycoprotein induction activity of the alkylidene phosphonate esters. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease.
    Type: Application
    Filed: September 16, 2015
    Publication date: September 28, 2017
    Inventors: SANDIP BHARATE, AJAY KUMAR, SUDHAKAR MANDA, PRASHANT JOSHI, SONALI BHARATE, ABUBAKAR WANI, SADHANA SHARMA, RAM VISHWAKARMA