Patents by Inventor Sudheer Chivukula

Sudheer Chivukula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Orally administrable solid pharmaceutical composition and a process thereof
    Patent number: 9241908
    Abstract: The invention relates to improvised pharmaceutical compositions permitting ingestion via oral delivery of proteins/peptides or their conjugates, and/or cation-insulin conjugate complexes demonstrating desirable pharmacokinetic profiles and potency in efficacy models of diabetes in dogs and humans. A preferred formulation comprises 0.01%-20% w/w of insulin, insulin compound conjugates and/or cation insulin conjugates, 10%-60% w/w of one or more fatty acid components selected from saturated or unsaturated C4-C12 fatty acids and/or salts of such fatty acids and additionally contains optimal amounts of other pharmaceutically suitable polymer excipients which permit improved solubility, dissolution rate and effective bioavailability of poorly water soluble compositions and consistent in-vivo release profiles upon scalability during manufacture. A further aspect of the invention features the process of preparing the aforesaid formulations.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: January 26, 2016
    Assignee: BIOCON LIMITED
    Inventors: Anand Khedkar, Sharath Kumar Mallapura Rangappa, Ramesh Subramani, Nitesh Dave, Devesh Radhakrishnan, Sundaresh Shankar, Sudheer Chivukula, Ranjith Ramakrishna, Shanmugam Thandava Murthy, Harish Venkatraman Pai, Nilanjan Sengupta, Ramakrishnan Melarkode, Harish Iyer
  • ORALLY ADMINISTERABLE SOLID PHARMACEUTICAL COMPOSITION AND A PROCESS THEREOF
    Publication number: 20100285143
    Abstract: The invention relates to improvised pharmaceutical compositions permitting ingestion via oral delivery of proteins/peptides or their conjugates, and/or cation-insulin conjugate complexes demonstrating desirable pharmacokinetic profiles and potency in efficacy models of diabetes in dogs and humans. A preferred formulation comprises 0.01%-20% w/w of insulin, insulin compound conjugates and/or cation insulin conjugates, 10%-60% w/w of one or more fatty acid components selected from saturated or unsaturated C4-C12 fatty acids and/or salts of such fatty acids and additionally contains optimal amounts of other pharmaceutically suitable polymer excipients which permit improved solubility, dissolution rate and effective bioavailability of poorly water soluble compositions and consistent in-vivo release profiles upon scalability during manufacture. A further aspect of the invention features the process of preparing the aforesaid formulations.
    Type: Application
    Filed: October 16, 2008
    Publication date: November 11, 2010
    Applicant: BIOCON LIMITED
    Inventors: Anand Khedkar, Sharath, Kumar, Mallapura Rangappa, Ramesh Subramani, Nitesh Dave, Devesh Radhakrishnan, Sundaresh Shankar, Sudheer Chivukula, Ranjith Ramakrishna, Shanmugam, Thandava Murthy, Harish Venkatraman Pai, Nilanjan Sengupta, Ramakrishnan Melarkode, Harish Iyer