Abstract: An Internet of Things (IoT) device may receive a network configuration profile including one or more parameters relating to a scan interval and a mode priority of the IoT device indicating a priority for a first IoT network over a second IoT network. The IoT device may scan for an availability of the first IoT network. Based on determining that the first IoT network is unavailable, the IoT device may scan for an availability of the second IoT network. Based on determining that the second IoT network is available, the IoT device may initiate a network connection with the second IoT network. While connected to the second IoT network, the IoT device may scan for the availability of the first IoT network. Based on determining that the first IoT network is available, the IoT device may initiate a network connection with the first IoT network.

Abstract: A user device may be provisioned with a list of paths for connecting to a network. A method may include determining that the user device has attached to a visited network and sending the visited network an indication of connectivity capabilities associated with the network. The method may include receiving an indication of one or more paths established from the visited network to the network based on capabilities of the visited network. The one or more paths may be included in the list of paths. The method may include transmitting data to or from the user device via a first path of the one or more paths.

Abstract: The disclosure relates to ophthalmic pharmaceutical compositions comprising pilocarpine or a pharmaceutically acceptable salt. Aspects of the disclosure further relate to uses and preparations of ophthalmic pharmaceutical compositions comprising pilocarpine or a pharmaceutically acceptable salt, for correcting presbyopia and other ocular conditions in a subject.

Abstract: The disclosure relates to ophthalmic pharmaceutical compositions comprising pilocarpine or a pharmaceutically acceptable salt. Aspects of the disclosure further relate to uses and preparations of ophthalmic pharmaceutical compositions comprising pilocarpine or a pharmaceutically acceptable salt, for correcting presbyopia and other ocular conditions in a subject.

Abstract: A surgical instrument and method of manipulating tissue of a patient includes a body, a shaft assembly extending distally therefrom, and an end effector extending distally from the shaft assembly and configured to receive a cartridge for manipulating tissue. The end effector has a distal end portion, a proximal end portion, a gap between the distal and proximal end portions, and a retaining pin. The retaining pin includes a distal head and is selectively movable from an open position to a locked closed position. In the open position, the retaining pin is proximally positioned such that the gap is configured to receive tissue. In the locked closed position, the retaining pin extends across the gap and is configured to capture tissue within the gap. The distal head of the retaining pin is configured engage and secure the distal end portion relative to the proximal end portion via the retaining pin.

Abstract: A method for manipulating tissue of a patient includes a surgical instrument having a handle assembly, a shaft assembly, and an end effector. The method includes positioning a tissue within a gap between a cartridge and an anvil and against a guide pin to laterally position the tissue relative to the cartridge and the anvil. The method also includes moving a retaining pin from an open position to a closed position to capture the tissue and moving the cartridge toward the anvil in a closed configuration. Furthermore, the method includes inhibiting deflection of a distal end portion of the end effector wherein at least at least one of the guide pin or the retaining pin connects to the distal end portion. The method further includes forming a plurality of staples within the tissue and cutting the tissue with a knife.

Abstract: The disclosure relates to ophthalmic pharmaceutical compositions comprising pilocarpine or a pharmaceutically acceptable salt. Aspects of the disclosure further relate to uses and preparations of ophthalmic pharmaceutical compositions comprising pilocarpine or a pharmaceutically acceptable salt, for correcting presbyopia and other ocular conditions in a subject.

Abstract: A method for manipulating tissue of a patient includes a surgical instrument having a handle assembly, a shaft assembly, and an end effector. The method includes positioning a tissue within a gap between a cartridge and an anvil and against a guide pin to laterally position the tissue relative to the cartridge and the anvil. The method also includes moving a retaining pin from an open position to a closed position to capture the tissue and moving the cartridge toward the anvil in a closed configuration. Furthermore, the method includes inhibiting deflection of a distal end portion of the end effector wherein at least at least one of the guide pin or the retaining pin connects to the distal end portion. The method further includes forming a plurality of staples within the tissue and cutting the tissue with a knife.

Abstract: The disclosure relates to ophthalmic pharmaceutical compositions comprising pilocarpine or a pharmaceutically acceptable salt. Aspects of the disclosure further relate to uses and preparations of ophthalmic pharmaceutical compositions comprising pilocarpine or a pharmaceutically acceptable salt, for correcting presbyopia and other ocular conditions in a subject.

Abstract: The disclosure relates to ophthalmic pharmaceutical compositions comprising pilocarpine or a pharmaceutically acceptable salt. Aspects of the disclosure further relate to uses and preparations of ophthalmic pharmaceutical compositions comprising pilocarpine or a pharmaceutically acceptable salt, for correcting presbyopia and other ocular conditions in a subject.

Abstract: A surgical instrument and method of manipulating tissue of a patient includes a body, a shaft assembly extending distally therefrom, and an end effector extending distally from the shaft assembly and configured to receive a cartridge for manipulating tissue. The end effector has a distal end portion, a proximal end portion, a gap between the distal and proximal end portions, and a retaining pin. The retaining pin includes a distal head and is selectively movable from an open position to a locked closed position. In the open position, the retaining pin is proximally positioned such that the gap is configured to receive tissue. In the locked closed position, the retaining pin extends across the gap and is configured to capture tissue within the gap. The distal head of the retaining pin is configured engage and secure the distal end portion relative to the proximal end portion via the retaining pin.

Abstract: A method for manipulating tissue of a patient includes a surgical instrument having a handle assembly, a shaft assembly, and an end effector. The method includes positioning a tissue within a gap between a cartridge and an anvil and against a guide pin to laterally position the tissue relative to the cartridge and the anvil. The method also includes moving a retaining pin from an open position to a closed position to capture the tissue and moving the cartridge toward the anvil in a closed configuration. Furthermore, the method includes inhibiting deflection of a distal end portion of the end effector wherein at least at least one of the guide pin or the retaining pin connects to the distal end portion. The method further includes forming a plurality of staples within the tissue and cutting the tissue with a knife.

Abstract: The object of the invention is to provide a pharmacological ophthalmic composition for use in the correction of presbyopia as a drop introduced onto the surface of the eye and surrounding soft tissue (drops) or as an implant surgically introduced into the subconjunctival space with sustained slow release application.

Abstract: A surgical instrument for applying a plurality of surgical fasteners to body tissue. The surgical instrument includes a frame having a handle at a proximal end thereof, and a support structure at a distal end thereof. The support structure adapted to support a plurality of surgical fasteners and is formed from aluminum.

Abstract: A method of manufacturing a surgical instrument for deploying a plurality of surgical fasteners. The method uses the step of building a frame with a proximal end and a distal end, and assembling a handle onto the proximal end of the frame. The method also involves the step of building a support structure at least partially from aluminum, such that the support structure is adapted to a plurality of surgical staples. The method also involves the step of assembling the support structure onto the distal end of the frame.