Abstract: Multifunctional cerium oxide-P7C3 (aminopropyl carbazole) chimeric nanocompositions and methods for using these nanocompositions for enhancing bone deposition are provided. For example, these nanocompositions can be used to combat radiation-induced bone tissue/cell damage, to treat any disorders that promote osteoporosis, and/or to treat bone trauma/injury.

Abstract: An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coating. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

Abstract: Disclosed herein are methods of producing large batch metal/metal oxide nanoparticles that involve dynamic dialysis. The methods allow for batches of greater than 1 liter to be synthesized and aged while reducing the amount of water usage.

Abstract: An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coating. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

Abstract: A ceria heterostructure may include one or more base materials and one or more ceria surface structures at least partially surrounding the one or more base materials, where defect states of the one or more ceria surface structures are reversibly controllable by controlling a stress on the one or more surface structures that is at least partially induced by the one or more base materials.

Abstract: The present disclosure relates to wound treatment and therapy and the promotion of tissue regeneration following injury. In particular, it relates to a microRNA-146a and nanoceria conjugate for improving wound healing and, in some embodiments, preventing adverse ventricular remodeling following myocardial infarction.

Abstract: The disclosure describes a method of removing and/or replacing an organic ligand from a surface of metal oxide nanoparticles. The method involves mixing a sample of metal oxide nanoparticles comprising an organic ligand in a liquid comprising an organic phase and an aqueous phase, the aqueous phase comprising at least one stripping agent, wherein mixing occurs under conditions to cause the stripping agent to interact with the surface of the metal oxide nanoparticles; removing the aqueous phase from the organic phase following mixing; and optionally, drying the aqueous phase removed from the organic phase.

Abstract: The present disclosure relates to compositions and methods for enhancing mosquito feeding.

Abstract: The present disclosure relates to wound treatment and therapy and the promotion of tissue regeneration following injury. In particular, it relates to a microRNA-146a and nanoceria conjugate for improving wound healing and, in some embodiments, preventing adverse ventricular remodeling following myocardial infarction.

Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating medulloblastoma. In one embodiment, a method for treating medulloblastoma in a patient comprises the step of administering a composition comprising an antisense oligonucleotides (ASO) targeting long non-coding ribonucleic acid HLX-2-7 (lnc-HLX-2-7). In particular embodiments, the medulloblastoma is group III medulloblastoma.

Abstract: Disclosed are real-time insect surveillance sensor devices and methods that use a colorimetric readout for detecting insect disease vectors (such as mosquitoes which can transmit pathogens such as DENV, CHIKV, and ZIKV). The method involves an attractive or feeding solution combined with detector conjugates. The conjugate can specifically detect proteins present in insect saliva and/or proteins specific to mosquito-borne pathogens.

Abstract: Cerium oxide nanoparticles (CNPs) have been proven to exhibit antioxidant properties attributed to its surface oxidation states (Ce4+ to Ce3+ and vice versa) mediated at the oxygen vacancies on the surface of CNPs. Different anions in precursor cerium salts were used to prepare CNPs resulting in disclosed CNPs with varying physicochemical properties such as dispersion stability, hydrodynamic size, and the signature surface chemistry. The antioxidant catalytic activity and oxidation potentials of different CNPs have been significantly altered with the change of anions in the precursor salts. For one, CNPs prepared using precursor salts containing NO3? and Cl? ions exhibited increased antioxidant activity than previously thought possible. The change in oxidation potentials of CNPs with the change in concentration of the nitrate and chloride ions indicates the disclosed CNP's have different surface chemistry and antioxidant properties. These compositions and methods of their synthesis are disclosed.

Abstract: Disclosed herein are rapid and residual disinfectant compositions that include a metal-associated cerium oxide nanoparticles. Also disclosed are methods of making disinfectant compositions. Films comprising the disclosed compositions are also disclosed as well as methods of disinfecting a surface.

Abstract: Disclosed herein is a nano-coating platform that is designed to ‘capture’ and ‘kill’ (i.e. inactivate) virus species to prevent surface to surface contamination/transmission and thereby the spread of novel viruses. The platform is comprised of alternating layers of charged polymers (producing a multi-layer coating). The cationic layer may be grafted with oligomeric species, chosen to bind strongly to unique/specific virus surface features, thereby mediating capture of the virus (with the choice of oligomeric species allowing generalization to a given virus). Natural light (excitation) to UV (local emission) up-converting nanoparticles are seeded into the anionic layer and mediate the inactivation (‘killing’) of the bound virus species.

Abstract: Cerium oxide nanoparticles (CNPs) have been proven to exhibit antioxidant properties attributed to its surface oxidation states (Ce4+ to Ce3+ and vice versa) mediated at the oxygen vacancies on the surface of CNPs. Different anions in precursor cerium salts were used to prepare CNPs resulting in disclosed CNPs with varying physicochemical properties such as dispersion stability, hydrodynamic size, and the signature surface chemistry. The antioxidant catalytic activity and oxidation potentials of different CNPs have been significantly altered with the change of anions in the precursor salts. For one, CNPs prepared using precursor salts containing NO3? and Cl? ions exhibited increased antioxidant activity than previously thought possible. The change in oxidation potentials of CNPs with the change in concentration of the nitrate and chloride ions indicates the disclosed CNP's have different surface chemistry and antioxidant properties. These compositions and methods of their synthesis are disclosed.

Abstract: Methods of protecting skin of a mammal by application of silk-derived compositions useful for treating or preventing a wide variety of skin conditions. Silk solutions and silk mats are prepared and applied to the skin surface. The silk compositions may be self-adhesive or sutured to cover a wound or area of skin exposed to physical stresses and strains, thereby preventing a wound and/or promoting wound healing.

Abstract: Methods of treating, reducing the risk of, preventing, or alleviating a symptom of inflammation or inflammatory disease, including wounds, diabetic ulcer, and inflammatory bowel disease, by administration of gel-based delivery particles, such as zwitterionic copolymer cryogels or chitosan microgels, containing cerium oxide nanoparticles.

Abstract: Disclosed herein is a nano-coating platform that is designed to ‘capture’ and ‘kill’ (i.e. inactivate) virus species to prevent surface to surface contamination/transmission and thereby the spread of novel viruses. The platform is comprised of alternating layers of charged polymers (producing a multi-layer coating). The cationic layer may be grafted with oligomeric species, chosen to bind strongly to unique/specific virus surface features, thereby mediating capture of the virus (with the choice of oligomeric species allowing generalization to a given virus). Natural light (excitation) to UV (local emission) up-converting nanoparticles are seeded into the anionic layer and mediate the inactivation (‘killing’) of the bound virus species.

Abstract: An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coating. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

Abstract: The present disclosure relates to compositions and methods for enhancing mosquito feeding.