Abstract: The present disclosure relates to compositions and methods for enhancing mosquito feeding.

Abstract: The present disclosure relates to wound treatment and therapy and the promotion of tissue regeneration following injury. In particular, it relates to a microRNA-146a and nanoceria conjugate for improving wound healing and, in some embodiments, preventing adverse ventricular remodeling following myocardial infarction.

Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating medulloblastoma. In one embodiment, a method for treating medulloblastoma in a patient comprises the step of administering a composition comprising an antisense oligonucleotides (ASO) targeting long non-coding ribonucleic acid HLX-2-7 (lnc-HLX-2-7). In particular embodiments, the medulloblastoma is group III medulloblastoma.

Abstract: Disclosed are real-time insect surveillance sensor devices and methods that use a colorimetric readout for detecting insect disease vectors (such as mosquitoes which can transmit pathogens such as DENV, CHIKV, and ZIKV). The method involves an attractive or feeding solution combined with detector conjugates. The conjugate can specifically detect proteins present in insect saliva and/or proteins specific to mosquito-borne pathogens.

Abstract: Cerium oxide nanoparticles (CNPs) have been proven to exhibit antioxidant properties attributed to its surface oxidation states (Ce4+ to Ce3+ and vice versa) mediated at the oxygen vacancies on the surface of CNPs. Different anions in precursor cerium salts were used to prepare CNPs resulting in disclosed CNPs with varying physicochemical properties such as dispersion stability, hydrodynamic size, and the signature surface chemistry. The antioxidant catalytic activity and oxidation potentials of different CNPs have been significantly altered with the change of anions in the precursor salts. For one, CNPs prepared using precursor salts containing NO3? and Cl? ions exhibited increased antioxidant activity than previously thought possible. The change in oxidation potentials of CNPs with the change in concentration of the nitrate and chloride ions indicates the disclosed CNP's have different surface chemistry and antioxidant properties. These compositions and methods of their synthesis are disclosed.

Abstract: Disclosed herein are rapid and residual disinfectant compositions that include a metal-associated cerium oxide nanoparticles. Also disclosed are methods of making disinfectant compositions. Films comprising the disclosed compositions are also disclosed as well as methods of disinfecting a surface.

Abstract: Disclosed herein is a nano-coating platform that is designed to ‘capture’ and ‘kill’ (i.e. inactivate) virus species to prevent surface to surface contamination/transmission and thereby the spread of novel viruses. The platform is comprised of alternating layers of charged polymers (producing a multi-layer coating). The cationic layer may be grafted with oligomeric species, chosen to bind strongly to unique/specific virus surface features, thereby mediating capture of the virus (with the choice of oligomeric species allowing generalization to a given virus). Natural light (excitation) to UV (local emission) up-converting nanoparticles are seeded into the anionic layer and mediate the inactivation (‘killing’) of the bound virus species.

Abstract: Cerium oxide nanoparticles (CNPs) have been proven to exhibit antioxidant properties attributed to its surface oxidation states (Ce4+ to Ce3+ and vice versa) mediated at the oxygen vacancies on the surface of CNPs. Different anions in precursor cerium salts were used to prepare CNPs resulting in disclosed CNPs with varying physicochemical properties such as dispersion stability, hydrodynamic size, and the signature surface chemistry. The antioxidant catalytic activity and oxidation potentials of different CNPs have been significantly altered with the change of anions in the precursor salts. For one, CNPs prepared using precursor salts containing NO3? and Cl? ions exhibited increased antioxidant activity than previously thought possible. The change in oxidation potentials of CNPs with the change in concentration of the nitrate and chloride ions indicates the disclosed CNP's have different surface chemistry and antioxidant properties. These compositions and methods of their synthesis are disclosed.

Abstract: Methods of protecting skin of a mammal by application of silk-derived compositions useful for treating or preventing a wide variety of skin conditions. Silk solutions and silk mats are prepared and applied to the skin surface. The silk compositions may be self-adhesive or sutured to cover a wound or area of skin exposed to physical stresses and strains, thereby preventing a wound and/or promoting wound healing.

Abstract: Methods of treating, reducing the risk of, preventing, or alleviating a symptom of inflammation or inflammatory disease, including wounds, diabetic ulcer, and inflammatory bowel disease, by administration of gel-based delivery particles, such as zwitterionic copolymer cryogels or chitosan microgels, containing cerium oxide nanoparticles.

Abstract: Disclosed herein is a nano-coating platform that is designed to ‘capture’ and ‘kill’ (i.e. inactivate) virus species to prevent surface to surface contamination/transmission and thereby the spread of novel viruses. The platform is comprised of alternating layers of charged polymers (producing a multi-layer coating). The cationic layer may be grafted with oligomeric species, chosen to bind strongly to unique/specific virus surface features, thereby mediating capture of the virus (with the choice of oligomeric species allowing generalization to a given virus). Natural light (excitation) to UV (local emission) up-converting nanoparticles are seeded into the anionic layer and mediate the inactivation (‘killing’) of the bound virus species.

Abstract: An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coating. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

Abstract: The present disclosure relates to compositions and methods for enhancing mosquito feeding.

Abstract: Cerium oxide nanoparticles have been found to enhance radiation-induced cancer cell death, while at the same time protecting normal tissue from radiation. The combination of cerium oxide nanoparticles with radiation has also been found to control and/or minimize the metastatic index. Cerium oxide nanoparticles have also been found to protect normal tissue subjected to irradiation from inflammation, and further to protect cells from reactive oxygen species. A cream comprising cerium oxide nanoparticles is formulated and used to protect skin against radiation-induced dermatitis.

Abstract: Disclosed are real-time insect surveillance sensor devices and methods that use a colorimetric readout for detecting insect disease vectors (such as mosquitoes which can transmit pathogens such as DENV, CHIKV, and ZIKV). The method involves an attractive or feeding solution combined with detector conjugates. The conjugate can specifically detect proteins present in insect saliva and/or proteins specific to mosquito-borne pathogens.

Abstract: An electrospun nanofibrous silk fibroin mat infused with a reactive oxygen species (ROS) detection reagent is presented herein. The ROS detection agent may be Amplex red. A method of real time detection of ROS in a wound site to determine the need for a dressing change is also presented. The method includes applying an electrospun nanofibrous silk fibroin mat infused with Amplex red to a wound site of a patient and detecting a change in color of the mat. A color change indicates a higher than normal level of ROS in the wound site. Depending on the degree of color change, a therapeutic agent may be administered to the wound site and a new mat applied to measure ROS in the wound site after therapy is administered.

Abstract: The present disclosure relates to compositions and methods for enhancing mosquito feeding.

Abstract: An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coaling. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

Abstract: A method of forming polymer composites includes mixing a transition metal oxide precursor including at least one transition metal, a polymer as a binder, a solvent for the polymer, and water to form a first solution including polymer-transition metal complexes. The polymer-transition metal complexes are hydrolyzed to produce a plurality of transition metal oxide nanoparticles, wherein water is added in the mixing in a stoichiometric excess for the hydrolyzing. The solvent and residual of the water remaining after the hydrolyzing are removed. A polymer composite including the transition metal oxide nanoparticles dispersed in the polymer results after the removing, where some of the polymer is chemically conjugated to a surface of the transition metal oxide nanoparticles.

Abstract: Disclosed are real-time insect surveillance sensor devices and methods that use a colorimetric readout for detecting insect disease vectors (such as mosquitoes which can transmit pathogens such as DENV, CHIKV, and ZIKV). The method involves an attractive or feeding solution combined with detector conjugates. The conjugate can specifically detect proteins present in insect saliva and/or proteins specific to mosquito-borne pathogens.