Patents by Inventor Sudipto CHAKRABORTTY

Sudipto CHAKRABORTTY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sequencing and analysis of exosome associated nucleic acids
    Patent number: 11396676
    Abstract: The invention provides a series of steps that prepare nucleic acids (RNA and/or DNA) isolated from extracellular vesicles for sequencing. This enables a wide diversity of RNAs and/or DNAs, to be efficiently detected. These can then be used to identify various attributes such as gene expression, alternative splicing, and the detection of both somatic and germline mutations including single nucleotide variants (SNV) and structural variations (insertions/deletions, fusions, inversions).
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: July 26, 2022
    Assignee: Exosome Diagnostics, Inc.
    Inventors: Johan Skog, Sudipto Chakrabortty, Dalin Chan, Michael Valentino, Vasisht Tadigotla, Robert Kitchen, Dominik Grimm, Wei Yu
  • Methods of treating glioblastoma in a subject informed by exosomal RNA signatures
    Patent number: 11345957
    Abstract: The present disclosure relates to methods for treating glioblastoma in a subject in need thereof using gene signatures in exosomal RNA derived from the subject. The gene signatures comprise: at least one of FAM229B, ZNF35, CTD-2647L4.4, CABP5, CYP20A1, CEP126, DTX2P1-UPK3BP1-PMS2P11, RP11-507K12.1, KRBA2, CALD1, LRFN1, RP2, SLC2A13, CDKL3, SLC8A3, ANTXR2, TIGD5, AC074289.1 RP11-932O9.7; at least one of tRNA-Lys-CTT-2-2, tRNA-Pro-AGG-2-7, LAMTOR2, RAD51AP1, DENND2A, A1BG, THSD1, CSF1, RP11-332M2.1, ZNF717, ZNF860, ORC6, Clorf50, PSPH, HIST1H4C, CYP2U1, THAP8, TMEM192, NAA20; or at least one of CREBBP, CXCR2 and S100A9. The treatment methods comprise measuring the expression level of at least one of the aforementioned genes in exosomal RNA from a subject and administering to the subject a glioblastoma treatment based on the expression level(s).
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: May 31, 2022
    Assignee: Exosome Diagnostics, Inc.
    Inventors: Robert Kitchen, Michael Valentino, Johan Skog, Vasisht Tadigotla, Dalin Chan, Sudipto Chakrabortty, James Hurley
  • SEQUENCING OF NUCLEIC ACIDS ASSOCIATED WITH EXOSOMAL ISOLATION FROM PATIENTS WITH GLIOBLASTOMA MULTIFORME
    Publication number: 20200224245
    Abstract: The present disclosure relates to methods for providing a clinical assessment of a subject in need thereof using the gene expression level measurements from exosomes derived from the subject.
    Type: Application
    Filed: July 18, 2018
    Publication date: July 16, 2020
    Inventors: Robert KITCHEN, Michael VALENTINO, Johan SKOG, Vasisht TADIGOTLA, Dalin CHAN, Sudipto CHAKRABORTTY, James HURLEY
  • SEQUENCING AND ANALYSIS OF EXOSOME ASSOCIATED NUCLEIC ACIDS
    Publication number: 20200208213
    Abstract: The invention provides a series of steps that prepare nucleic acids (RNA and/or DNA) isolated from extracellular vesicles for sequencing. This enables a wide diversity of RNAs and/or DNAs, to be efficiently detected. These can then be used to identify various attributes such as gene expression, alternative splicing, and the detection of both somatic and germline mutations including single nucleotide variants (SNV) and structural variations (insertions/deletions, fusions, inversions).
    Type: Application
    Filed: October 23, 2017
    Publication date: July 2, 2020
    Inventors: Johan SKOG, Sudipto CHAKRABORTTY, Dalin CHAN, Michael VALENTINO, Vasisht TADIGOTLA, Robert KITCHEN, Dominik GRIMM, Wei YU