Abstract: An enclosure with two hinged clamping members (1 and 2) with finger-like prongs on each identical end is provided for holding together the end components (4, 5, 6, 7 and 10) of a multiple intravenous (I.V.) needle and tubing flange set-up. The end components may be either a plastic hub, a needle through the rubber stopper of the side infusion port of the main IV line, the terminal portion of an IV extension set or the connector site of the IV line to the actual IV catheter. When an I.V. needle and tube are connected and the enclosure is open, the connected parts can be placed therein and then locking members (16) are snapped together to hold the components securely connected. Convenient snap-locking can be utilized to hold the locking members (16) together. A use method includes inserting a needle (4) into a flange cap (10) and then placing the joined components into the enclosure, locking the locking members (16) shut and then opening them for changes and alterations as necessary.