Abstract: Scoring functions for predicting response of a dMMR and/or MSI-H colorectal tumor to a PD-1 axis-directed therapy are disclosed, as well as methods and systems for evaluating tissue samples for the presence of feature metrics useful in computing such scoring functions. The scoring functions integrate one or more spatial relationships between cell types into a numerical indication of the likelihood that the tumor will respond to the PD-1 axis-directed therapy. Based on the output of the scoring function, a subject may then be selected to receive a PD-1 axis-directed therapy (if the scoring function indicates a sufficient likelihood of positive response) or an alternative therapy (if the scoring function indicates an insufficient likelihood of positive response).

Abstract: A system for isolating requests that comprises, a shared command queue, a first virtual computational resource and a second virtual computational resources. The first virtual computational resources comprises a policy engine configured to access policies comprising criteria for assigning commands corresponding to requests from tenants to compartments, determine, according to the policies, compartments to which to assign the commands corresponding to the requests, produce the commands corresponding to the requests, and queue the commands in the shared command queue, each command comprising compartment assignment information.

Abstract: A system for isolating requests that comprises, a shared command queue, a first virtual computational resource and a second virtual computational resources. The first virtual computational resources comprises a policy engine configured to access policies comprising criteria for assigning commands corresponding to requests from tenants to compartments, determine, according to the policies, compartments to which to assign the commands corresponding to the requests, produce the commands corresponding to the requests, and queue the commands in the shared command queue, each command comprising compartment assignment information.

Abstract: Provided herein are methods for diagnosing a psychotic disorder, such as schizophrenia, schizoaffective disorder or psychosis, predicated on a determination of a methylation phenotype of the subject based in part on the identity of a specific polymorphism in the MTHFR gene and the analysis of a suite of biomarkers and other functional measures and indices. Also provided herein are methods for predicting prognosis and functional outcomes for subjects having a psychotic disorder, and for treating subjects having a psychotic disorder.

Abstract: A system for isolating requests that comprises, a shared command queue, a first virtual computational resource and a second virtual computational resources. The first virtual computational resources comprises a policy engine configured to access policies comprising criteria for assigning commands corresponding to requests from tenants to compartments, determine, according to the policies, compartments to which to assign the commands corresponding to the requests, produce the commands corresponding to the requests, and queue the commands in the shared command queue, each command comprising compartment assignment information.

Abstract: A system for isolating requests that comprises, a shared command queue, a first virtual computational resource and a second virtual computational resources. The first virtual computational resources comprises a policy engine configured to access policies comprising criteria for assigning commands corresponding to requests from tenants to compartments, determine, according to the policies, compartments to which to assign the commands corresponding to the requests, produce the commands corresponding to the requests, and queue the commands in the shared command queue, each command comprising compartment assignment information.

Abstract: A system for isolating requests that comprises, a shared command queue, a first virtual computational resource and a second virtual computational resources. The first virtual computational resources comprises a policy engine configured to access policies comprising criteria for assigning commands corresponding to requests from tenants to compartments, determine, according to the policies, compartments to which to assign the commands corresponding to the requests, produce the commands corresponding to the requests, and queue the commands in the shared command queue, each command comprising compartment assignment information.

Abstract: Embodiments of the present invention provide methods for diagnosing schizophrenia, schizo-affective disorder and/or psychosis in an individual or predicting risk of the individual developing schizophrenia, schizo-affective disorder or psychosis, by determining values for one or more markers in each of five domains, namely a neurotransmitter domain, an oxidative stress domain, a nutrition-biochemistry domain, a visual processing domain and an auditory processing domain.

Abstract: In one embodiment, the invention provides a rupture disk assembly having a rupture disk and a rupture disk holder. The rupture disk holder has a first annular member downstream of the rupture disk, a second annular member upstream of the rupture disk, and an optional third annular member upstream of the second annular member. An outer peripheral portion of the rupture disk is sandwiched between the first and second annular members; and, if a third annular member is present, (a) the second annular member is sandwiched between the outer peripheral portion of the rupture disk and the third annular member, and (b) the third annular member includes a fluid port aimed at the rupture disk. However, if the third annular member is not present, the second annular member includes a fluid port aimed at the rupture disk.

Abstract: In one embodiment, the invention provides a rupture disk assembly having a rupture disk and a rupture disk holder. The rupture disk holder has a first annular member downstream of the rupture disk, a second annular member upstream of the rupture disk, and an optional third annular member upstream of the second annular member. An outer peripheral portion of the rupture disk is sandwiched between the first and second annular members; and, if a third annular member is present, (a) the second annular member is sandwiched between the outer peripheral portion of the rupture disk and the third annular member, and (b) the third annular member includes a fluid port aimed at the rupture disk. However, if the third annular member is not present, the second annular member includes a fluid port aimed at the rupture disk.

Abstract: A support for a predetermined container having a rim e.g. at its top opening, the support comprising a lid or a supporting ring, constructed to interfit e.g. with the rim of the container, wherein there is a suspender, formed with the lid or supporting ring and deflectable from an as-formed position to an upstanding position in which it is capable of carrying weight of the container. In most cases suspenders extend inwardly of a rim of the lid or supporting ring. Free-ended flexible finger suspenders of synthetic resin, are shown, formed integrally with the lid or supporting ring as a molded unit. The lids or rings are associated with closure surfaces, such as closure portions molded with the lid or ring, closure inserts, or closure films or foils on the container itself. The suspenders are useful to the consumer in enabling improved carrying of the merchandise with other items or in intertwined fusion with the like items, and to the storekeeper in suspending merchandise.

Abstract: In one embodiment, the invention provides a rupture disk assembly having a rupture disk and a rupture disk holder. The rupture disk holder has a first annular member downstream of the rupture disk, a second annular member upstream of the rupture disk, and an optional third annular member upstream of the second annular member. An outer peripheral portion of the rupture disk is sandwiched between the first and second annular members; and, if a third annular member is present, (a) the second annular member is sandwiched between the outer peripheral portion of the rupture disk and the third annular member, and (b) the third annular member includes a fluid port aimed at the rupture disk. However, if the third annular member is not present, the second annular member includes a fluid port aimed at the rupture disk.

Abstract: A support for a predetermined container (2, 2′, 2″, 11, 71, 81, 92, 94) having a rim e.g. at its top opening, the support comprising a lid or a supporting ring (4, 4′, 4″, 70, 80, 90), constructed to interfit e.g. with the rim of the container, wherein there is a suspender (FS, FS1, FS2, FS3, FS4), formed with the lid or supporting ring and deflectable from an as-formed position to an upstanding position in which it is capable of carrying weight of the container. In most cases suspenders extend inwardly of a rim of the lid or supporting ring. Free-ended flexible finger suspenders of synthetic resin, are shown, formed integrally with the lid or supporting ring as a molded unit. The lids or rings are associated with closure surfaces, such as closure portions molded with the lid or ring, closure inserts, or closure films or foils on the container itself.

Abstract: In one embodiment, the invention provides a rupture disk assembly having a rupture disk and a rupture disk holder. The rupture disk holder has a first annular member downstream of the rupture disk, a second annular member upstream of the rupture disk, and an optional third annular member upstream of the second annular member. An outer peripheral portion of the rupture disk is sandwiched between the first and second annular members; and, if a third annular member is present, (a) the second annular member is sandwiched between the outer peripheral portion of the rupture disk and the third annular member, and (b) the third annular member includes a fluid port aimed at the rupture disk. However, if the third annular member is not present, the second annular member includes a fluid port aimed at the rupture disk.

Abstract: A disposable package for consumable contents includes a container having a surrounding wall of upstanding, generally flexible material extending from a container bottom to a wide mouth defined by a rim formation of greater relative thickness than said surrounding wall, said mouth being of greater than two inch minimum horizontal dimension and being about as wide as the horizontal cross-section of a top of the container.

Abstract: The invention relates to a method for treating pruritus by administering a therapeutically effective amount of a PAF antagonist to a mammal afflicted with pruritus. The PAF antagonists may, for example, be selected from synthetic PAF analogues, natural products isolated from plants having PAF antagonist activity, and triazolobenzodiazepines. The PAF antagonists are preferably applied topically to the afflicted site but systemic such as oral, parenteral, nasal and intrarectal administration, is also possible.