Abstract: Embodiments of the disclosure concern systems, methods, and/or compositions for cultivation of mammalian viruses, including at least human noroviruses and sapoviruses within the Caliciviridae family of viruses. The ex vivo culture systems include intestinal enteroids in combination with bile or a functionally active fraction or component thereof. In specific embodiments, the culture system is utilized to test inactivation compounds for therapeutic or environmental efficacy and to test contaminated comestibles and/or environmental entities for determination of the presence of infectious virus. Furthermore, antiviral compositions may be tested using systems of the disclosure, including drugs, small molecule inhibitors, and biologics such as neutralizing monoclonal antibodies.

Abstract: A cellular digital packet data (CDPD) system includes a mobile data base station (MDBS) configured to interface easily with an advanced mobile phone system (AMPS). The elements of the MDBS are arranged on modules and the functionality of the MDBS is divided among the modules to facilitate flexibility, compactness and quick expansion of the MDBS. To further facilitate compactness, the MDBS includes a transceiver/modem board which uses a single chip to carry out delta-sigma modulation. In order to maintain the integrity of CDPD transmission, a channel hopping scheme is used based upon avoidance of AMPS channel use. A distinctive protocol is used to encapsulate control/query/response data for transmission throughout the CDPD system. This protocol also facilitates easy control of each MDBS throughout the system.

Abstract: A cellular digital packet data (CDPD) system includes a mobile data base station (MDBS) configured to interface easily with an advanced mobile phone system (AMPS). The elements of the MDBS are arranged on modules and the functionality of the MDBS is divided among the modules to facilitate flexibility, compactness and quick expansion of the MDBS. To further facilitate compactness, the MDBS includes a transceiver/modem board which uses a single chip to carry out delta-sigma modulation. In order to maintain the integrity of CDPD transmission, a channel hopping scheme is used based upon avoidance of AMPS channel use. A distinctive protocol is used to encapsulate control/query/response data for transmission throughout the CDPD system. This protocol also facilitates easy control of each MDBS throughout the system.