Abstract: A denture cleaning brush for use in removing food, debris, and bacteria from dentures. The denture cleaning brush includes a handle having a first end with a head thereon and a second end to be held by the user. The handle includes one or more gripping regions thereon that include a high friction or ridged surface to allow the user to more easily hold the handle. The head includes a plurality of tufted bristles extending radially outward therefrom. The bristles are located on the sides and front end of the head and are positioned on a lower portion of the brush head. In this way, the bristles are configured to contact the bottom and sidewalls of the channel of dentures when the denture cleaning brush is positioned therein, allowing the user to easily and fully clean the dentures.