Abstract: The invention provides a body fluid treatment method for selective ex vivo killing of malignant lymphoma cells, leukemia cells or activated macrophages in a body fluid, the body fluid treatment method comprising: an addition step wherein a compound represented by formula (I) below is added to a body fluid containing malignant lymphoma cells, leukemia cells or activated macrophages that has been removed from the body, to yield an addition mixture; and an excitation step wherein the addition mixture is irradiated with excitation light to excite the compound. According to the invention, there is provided a method for selective ex vivo killing of malignant lymphoma cells, leukemia cells or activated macrophages in a body fluid while avoiding adverse effects on normal cells.

Abstract: This apparatus includes a laser light source S2 which irradiates a spatial light modulator (SLM) 11 with a laser beam LR. Individual optical systems are arranged such that the laser beam reflected by the SLM 11 irradiates a region to be treated. When this configuration is used, the laser beam reflectivity can be made much higher than when a transmitting device is used. This allows high-efficiency laser beam irradiation. A predetermined pattern is written in the SLM 11, and this predetermined pattern is preferably a hologram pattern.

Abstract: This apparatus includes a laser light source S2 which irradiates a spatial light modulator (SLM) 11 with a laser beam LR. Individual optical systems are arranged such that the laser beam reflected by the SLM 11 irradiates a region to be treated. When this configuration is used, the laser beam reflectivity can be made much higher than when a transmitting device is used. This allows high-efficiency laser beam irradiation. A predetermined pattern is written in the SLM 11, and this predetermined pattern is preferably a hologram pattern.