Patents by Inventor Sufeng Zhang

Sufeng Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240119278
    Abstract: Techniques for using transfer learning to address label data shortage in seniority modeling for an online service are disclosed herein. In some embodiments, a computer-implemented method comprises training an initialized neural network using training examples comprising profile data and labels for the profile data, where each label comprises a standardized position title, and the training of the initialized neural network forms a pre-trained neural network. Next, the computer system may train the pre-trained neural network using training examples comprising profile data and labels for the profile data, where the labels comprise a position seniority, and the training of the pre-trained neural network forms a fine-tuned neural network. The computer system may then compute the position seniority for a user based on profile data of the user using the fine-tuned neural network, and use the position seniority of the user in an application of an online service.
    Type: Application
    Filed: October 7, 2022
    Publication date: April 11, 2024
    Inventors: Zheng ZHANG, Sufeng Niu, Di Zhou, Jacob BOLLINGER
  • Publication number: 20230346946
    Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
    Type: Application
    Filed: May 1, 2023
    Publication date: November 2, 2023
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer
  • Patent number: 11684583
    Abstract: Compositions, articles, and methods for targeted drug delivery, such as thermoresponsive hydrogel polymers, are generally provided. In one aspect, the compositions and articles comprise a thermoresponsive hydrogel polymer comprising a releasable therapeutic agent. In some cases, the compositions described herein have advantageous combinations of properties including mechanical strength, biocompatibility, tunable charge densities, thermal responsiveness, drug loading, and/or configurations for targeted drug delivery. In one embodiment, the composition comprises a solution comprising a thermoresponsive polymer including one or more ligands attached to the polymer, wherein the solution is configured to undergo a sol-to-gel transition under physiological conditions. In another embodiment, the composition comprises a plurality of nanoparticles e.g., associated with the thermoresponsive polymer. In yet another embodiment, the composition comprises a therapeutic agent e.g.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: June 27, 2023
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Ashok Kakkar, Joshua Korzenik, Robert S. Langer, Sufeng Zhang
  • Patent number: 11672864
    Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: June 13, 2023
    Assignees: The Brigham And Women's Hospital, Inc., Massachusetts Institute Of Technology
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer
  • Patent number: 11623204
    Abstract: A method for preparing a modified cellulose aerogel for glycoprotein separation is provided. In this method, cellulose aerogel is employed as a substrate. The cellulose aerogel is known to have a three-dimensional network structure with extremely high porosity and specific surface area and extremely low density. So, by using the cellulose aerogel as a substrate, it is possible to provide the glycoproteins to be separated with more binding sites. PEI dendrimer has abundant functional groups and can easily be modified. By modifying the cellulose aerogel substrate with the PEI dendrimer, it is possible to improve the density of the phenylboronic acid bound to the substrate, thereby leading to higher affinity toward the glycoproteins to be separated.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: April 11, 2023
    Assignee: Shaanxi University of Science & Technology
    Inventors: Sufeng Zhang, Xue Yao, Liwei Qian, Chen Hua, Ning Wei, Quansheng Wang
  • Publication number: 20220080384
    Abstract: A method for preparing a modified cellulose aerogel for glycoprotein separation is provided. In this method, cellulose aerogel is employed as a substrate. The cellulose aerogel is known to have a three-dimensional network structure with extremely high porosity and specific surface area and extremely low density. So, by using the cellulose aerogel as a substrate, it is possible to provide the glycoproteins to be separated with more binding sites. PEI dendrimer has abundant functional groups and can easily be modified. By modifying the cellulose aerogel substrate with the PEI dendrimer, it is possible to improve the density of the phenylboronic acid bound to the substrate, thereby leading to higher affinity toward the glycoproteins to be separated.
    Type: Application
    Filed: September 9, 2021
    Publication date: March 17, 2022
    Applicant: Shaanxi University of Science & Technology
    Inventors: Sufeng ZHANG, Xue YAO, Liwei QIAN, Chen HUA, Ning WEI, Quansheng WANG
  • Publication number: 20210008213
    Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
    Type: Application
    Filed: June 8, 2020
    Publication date: January 14, 2021
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer
  • Publication number: 20200352870
    Abstract: Compositions, articles, and methods for targeted drug delivery, such as thermoresponsive hydrogel polymers, are generally provided. In one aspect, the compositions and articles comprise a thermoresponsive hydrogel polymer comprising a releasable therapeutic agent. In some cases, the compositions described herein have advantageous combinations of properties including mechanical strength, biocompatibility, tunable charge densities, thermal responsiveness, drug loading, and/or configurations for targeted drug delivery. In one embodiment, the composition comprises a solution comprising a thermoresponsive polymer including one or more ligands attached to the polymer, wherein the solution is configured to undergo a sol-to-gel transition under physiological conditions. In another embodiment, the composition comprises a plurality of nanoparticles e.g., associated with the thermoresponsive polymer. In yet another embodiment, the composition comprises a therapeutic agent e.g.
    Type: Application
    Filed: December 8, 2017
    Publication date: November 12, 2020
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital Inc.
    Inventors: Carlo Giovanni Traverso, Ashok Kakkar, Joshua Korzenik, Robert S. Langer, Sufeng Zhang
  • Patent number: 10675351
    Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: June 9, 2020
    Assignees: The Brigham and Women's Hospital, Inc., Massachusetts Institute of Technology
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer
  • Publication number: 20180318423
    Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
    Type: Application
    Filed: May 4, 2018
    Publication date: November 8, 2018
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer
  • Patent number: 9974859
    Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: May 22, 2018
    Assignees: The Brigham and Women's Hospital, Inc., Massachusetts Institute of TechnoIogy
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer
  • Publication number: 20170000888
    Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
    Type: Application
    Filed: June 6, 2016
    Publication date: January 5, 2017
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer
  • Publication number: 20150354144
    Abstract: Electrically, insulating composite material is obtained from the form of a paper of a pressboard with an electrical device through post-treating by electron beam irradiation treatment, gamma irradiation treatment or x-ray irradiation treatment.
    Type: Application
    Filed: May 7, 2013
    Publication date: December 10, 2015
    Inventors: JIANSHENG CHEN, CHAU-HON HO, JENS ROCKS, SUFENG ZHANG, LARS SCHMIDT, YONG FENG, DELUN MENG, ZHAOXIA SUN
  • Publication number: 20130280334
    Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
    Type: Application
    Filed: September 23, 2011
    Publication date: October 24, 2013
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer