Abstract: The present disclosure relates to chemical dyes useful for staining and imaging of cells. In particular, the disclosure relates to compound of Formula I, method of preparation thereof, and it's use as a fluorescent probe for staining and/or imaging mitochondria in cells, tissues or animals, resulting in a range of applications including, but not limiting, to sensing local ordering or viscosity of mitochondria, tracking mitochondrial mobility, comparing & evaluating mitochondrial function, local ordering, microviscosity and dynamics. Said dyes have additional advantages including, but not limiting, to low toxicity, longer shelf-life, generate little or no reactive species upon long term light irradiation and do not perturb the functionality of the mitochondria in cells compared to prior art dyes.

Abstract: The present disclosure relates to chemical dyes useful for staining and imaging of cells. In particular, the disclosure relates to compound of Formula I, method of preparation thereof, and it's use as a fluorescent probe for staining and/or imaging mitochondria in cells, tissues or animals, resulting in a range of applications including, but not limiting, to sensing local ordering or viscosity of mitochondria, tracking mitochondrial mobility, comparing & evaluating mitochondrial function, local ordering, microviscosity and dynamics. Said dyes have additional advantages including, but not limiting, to low toxicity, longer shelf-life, generate little or no reactive species upon long term light irradiation and do not perturb the functionality of the mitochondria in cells compared to prior art dyes.

Abstract: The present technology provides liquid quality assessment systems and methods for their preparation and use. The systems can include a light source configured to illuminate a liquid sample, a reflecting surface configured to reflect light scattered by the liquid sample, and a detector configured to detect light intensity, wherein the light source illuminates the liquid sample with a first incident light when the reflecting surface is absent; the detector detects a first light scattered by the liquid sample in response to the first incident light; the light source illuminates the liquid sample with a second incident light when the reflecting surface is present; and the detector detects a second light which is a combination of light scattered by the liquid sample in response to the second incident light and light reflected by the reflecting surface of light scattered by the liquid sample in response to the second incident light.

Abstract: Exposure to a static magnetic field changes the fluorescence intensity of a wide range of fluorophores, including small molecules (e.g., tryptophan), complex organizations of fluorophores (e.g., proteins), quantum dots, nanoparticles, and other materials. Different materials may experience different changes in fluorescence emission upon exposure to a magnetic field—for instance, some or all of a material's fluorescence emission spectrum may increase in amplitude or shift in wavelength. Different materials may also experience different changes in relaxation time, which is the time constant associated with fluorescence decay. These magnetically induced differences fluorescence emission spectra and decay can be used to identify, classify, or sort materials noninvasively.

Abstract: The present technology provides liquid quality assessment systems and methods for their preparation and use. The systems can include a light source configured to illuminate a liquid sample, a reflecting surface configured to reflect light scattered by the liquid sample, and a detector configured to detect light intensity, wherein the light source illuminates the liquid sample with a first incident light when the reflecting surface is absent; the detector detects a first light scattered by the liquid sample in response to the first incident light; the light source illuminates the liquid sample with a second incident light when the reflecting surface is present; and the detector detects a second light which is a combination of light scattered by the liquid sample in response to the second incident light and light reflected by the reflecting surface of light scattered by the liquid sample in response to the second incident light.

Abstract: Exposure to a static magnetic field changes the fluorescence intensity of a wide range of fluorophores, including small molecules (e.g., tryptophan), complex organizations of fluorophores (e.g., proteins), quantum dots, nanoparticles, and other materials. Different materials may experience different changes in fluorescence emission upon exposure to a magnetic field—for instance, some or all of a material's fluorescence emission spectrum may increase in amplitude or shift in wavelength. Different materials may also experience different changes in relaxation time, which is the time constant associated with fluorescence decay. These magnetically induced differences fluorescence emission spectra and decay can be used to identify, classify, or sort materials noninvasively.

Abstract: Disclosed herein are methods of diagnosing, monitoring and treating iron disorders using assays of serum ferritin. Some embodiments relate to detection and management of iron and iron-containing proteins in the body. For instance, the level of ferritin may be determined by contacting a sample with one or more magnetic nanoparticles; measuring an absorbance of the sample in the presence and in the absence of a magnetic field; and comparing the absorbance of the sample in the presence of the magnetic field to the absorbance of the sample in the absence of the magnetic field to determine the level of ferritin in the sample.