Patents by Inventor Suganthini Nanthakumar

Suganthini Nanthakumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic inhibitors of c-Met and uses thereof
    Patent number: 8481538
    Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: July 9, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alexander Aronov, Jon Come, John Court, David Deininger, David Lauffer, Pan Li, Kira McGinty, Suganthini Nanthakumar, Dean Stamos, Kirk Tanner
  • HETEROCYCLIC INHIBITORS OF C-MET AND USES THEREOF
    Publication number: 20100144739
    Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
    Type: Application
    Filed: September 18, 2007
    Publication date: June 10, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Alexander Aronov, Jon Come, John Court, David Deininger, David Lauffer, Pan Li, Kira McGinty, Suganthini Nanthakumar, Dean Stamos, Kirk Tanner
  • Azaindoles useful as inhibitors of rock and other protein kinases
    Patent number: 7514448
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: April 4, 2005
    Date of Patent: April 7, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Andrew Miller, Juan-Miguel Jimenez, Craig Marhefka, Jingrong Cao, John Court, Upul Bandarage, Huai Gao, Suganthini Nanthakumar
  • Thiazole compounds useful as inhibitors of protein kinase
    Patent number: 7488727
    Abstract: The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: February 10, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: John Cochran, Suganthini Nanthakumar, Edmund Harrington, Jian Wang
  • Protein kinase inhibitors and uses thereof
    Patent number: 7304071
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formulae I and V: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, T, m, n, p, Q, Q?, R1, R2, Rx, R3, and R6 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: December 4, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: John Cochran, Jeremy Green, Michael R. Hale, Brian Ledford, Francois Maltais, Suganthini Nanthakumar
  • THIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASE
    Publication number: 20070249645
    Abstract: The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Application
    Filed: June 15, 2007
    Publication date: October 25, 2007
    Inventors: John Cochran, Suganthini Nanthakumar, Edmund Harrington, Jian Wang
  • Thiazole compounds useful as inhibitors of protein kinase
    Patent number: 7256190
    Abstract: The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Grant
    Filed: July 13, 2004
    Date of Patent: August 14, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: John Cochran, Suganthini Nanthakumar, Edmund Harrington, Jian Wang
  • Azaindoles useful as inhibitors of rock and other protein kinases
    Publication number: 20060003968
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: April 4, 2005
    Publication date: January 5, 2006
    Inventors: Jeremy Green, Andrew Miller, Juan-Miguel Jimenez, Craig Marhefka, Jingrong Cao, John Court, Upul Bandarage, Huai Gao, Suganthini Nanthakumar
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Patent number: 6949544
    Abstract: The present invention provide a compound of formula I or II: or a pharmaceutically acceptable derivative thereof, wherein R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli; and Src-family kinases, especially Src and Lck kinases. These compounds are also inhibitors of GSK3 and CDK2 kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: September 27, 2005
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Randy S. Bethiel, John Cochran, Young-Choon Moon, Suganthini Nanthakumar
  • Thiazole compounds useful as inhibitors of protein kinase
    Publication number: 20050004152
    Abstract: The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Application
    Filed: July 13, 2004
    Publication date: January 6, 2005
    Inventors: John Cochran, Suganthini Nanthakumar, Edmund Harrington, Jian Wang
  • Thiazole compounds useful as inhibitors of protein kinase
    Patent number: 6762179
    Abstract: The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof, wherein Ar1 is phenyl and R1 is as defined in the specification. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: July 13, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: John Cochran, Suganthini Nanthakumar, Edmund Harrington, Jian Wang
  • Protein kinase inhibitors and uses thereof
    Publication number: 20040106615
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formulae I and V: 1
    Type: Application
    Filed: August 12, 2003
    Publication date: June 3, 2004
    Inventors: John Cochran, Jeremy Green, Michael R. Hale, Brian Ledford, Francois Maltais, Suganthini Nanthakumar
  • Thiazole compounds useful as inhibitors of protein kinase
    Publication number: 20030119856
    Abstract: The present invention provides a compound of formula I: 1
    Type: Application
    Filed: May 23, 2002
    Publication date: June 26, 2003
    Inventors: John Cochran, Suganthini Nanthakumar, Edmund Harrington, Jian Wang
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Publication number: 20030087922
    Abstract: The present invention provide a compound of formula I or II: 1
    Type: Application
    Filed: March 28, 2002
    Publication date: May 8, 2003
    Inventors: Randy S. Bethiel, John Cochran, Young-Choon Moon, Suganthini Nanthakumar