Patents by Inventor Suguru Akamatsu
Suguru Akamatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20200096500Abstract: This invention provides a method for measuring glucose metabolism ability of a subject and a composition that is suitably used in the method. The method for measuring glucose metabolism ability of the present invention is as follows: a method for measuring glucose metabolism ability of a subject, using a composition for measuring glucose metabolism ability, the composition comprising, as an active ingredient, glucose labeled with at least one isotope of C, wherein the glucose is converted in the body into labeled carbon dioxide that is excreted in expired air, the method comprising steps (a) and (b) below: (a) administering the composition to the subject and collecting expired air; and (b) determining the ratio of labeled CO2 amount to unlabeled CO2 amount or the ratio of labeled CO2 amount to total CO2 amount.Type: ApplicationFiled: January 8, 2019Publication date: March 26, 2020Inventors: Makoto Inada, Jun-ichi Kunizaki, Kazuki Tobita, Suguru Akamatsu
-
Patent number: 10228365Abstract: A method is provided for measuring and evaluating rapidly and with high accuracy a subject's glucose metabolism. The method uses a labeled C-breath test and a composition that is suitably used in the method. The composition contains as active ingredient glucose labeled with at least one isotope of C, wherein the glucose is converted in the subject to labeled carbon dioxide that is excreted in expired air. This method also allows for the determination of a stage of a patient in whom diabetes has developed as well as for a stage before the onset of diabetes, and monitors the state (diabetes condition including a state before onset of diabetes) over time.Type: GrantFiled: August 20, 2013Date of Patent: March 12, 2019Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Makoto Inada, Jun-ichi Kunizaki, Kazuki Tobita, Suguru Akamatsu
-
Patent number: 9933442Abstract: A monoclonal antibody that does not show a crossreactivity with middle-molecular weight (MMW) adiponectin and specifically reacts with high-molecular weight (HMW) adiponectin alone is disclosed. The monoclonal antibody of the present invention can be produced by using HMW adiponectin as an antigen. According to the monoclonal antibody of the present invention, a convenient, high-accurate, and versatile reagent for analyzing HMW adiponectin can be provided.Type: GrantFiled: October 7, 2014Date of Patent: April 3, 2018Assignee: LSI MEDIENCE CORPORATIONInventors: Suguru Akamatsu, Kiyonori Katsuragi, Hideaki Onishi, Midori Abe, Toru Hadama, Ayako Nishimura, Mio Ooguchi
-
Publication number: 20180003695Abstract: The present invention provides a method for measuring the gastric acidity of a mammal using a 13C-labeled carbonate compound. Specifically, the present invention relates to a method for measuring the gastric acidity of a mammal including the following steps: (1) using, as a test sample, expired air of a mammalian subject excreted at any point in time within 30 minutes after oral administration of a predetermined amount of a 13C-labeled carbonate compound, measuring behavior of 13CO2 in the expired air; (2) comparing the behavior of 13CO2 (measured 13CO2 behavior) obtained in step (1) with the behavior of corresponding 13CO2 (reference 13CO2 behavior) that has been obtained beforehand in a control mammal; and (3) determining the gastric acidity of the mammalian subject based on a difference between the reference 13CO2 behavior and the measured 13CO2 behavior obtained above.Type: ApplicationFiled: September 15, 2017Publication date: January 4, 2018Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Makoto INADA, Jun-ichi KUNIZAKI, Kazuki TOBITA, Suguru AKAMATSU, Shinji llZUKA
-
Publication number: 20150204852Abstract: This invention provides a method for measuring glucose metabolism ability of a subject and a composition that is suitably used in the method. The method for measuring glucose metabolism ability of the present invention is as follows: a method for measuring glucose metabolism ability of a subject, using a composition for measuring glucose metabolism ability, the composition comprising, as an active ingredient, glucose labeled with at least one isotope of C, wherein the glucose is converted in the body into labeled carbon dioxide that is excreted in expired air, the method comprising steps (a) and (b) below: (a) administering the composition to the subject and collecting expired air; and (b) determining the ratio of labeled CO2 amount to unlabeled CO2 amount or the ratio of labeled CO2 amount to total CO2 amount.Type: ApplicationFiled: August 20, 2013Publication date: July 23, 2015Inventors: Makoto Inada, Jun-ichi Kunizaki, Kazuki Tobita, Suguru Akamatsu
-
Publication number: 20150025226Abstract: A monoclonal antibody that does not show a crossreactivity with middle-molecular weight (MMW) adiponectin and specifically reacts with high-molecular weight (HMW) adiponectin alone is disclosed. The monoclonal antibody of the present invention can be produced by using HMW adiponectin as an antigen. According to the monoclonal antibody of the present invention, a convenient, high-accurate, and versatile reagent for analyzing HMW adiponectin can be provided.Type: ApplicationFiled: October 7, 2014Publication date: January 22, 2015Inventors: Suguru Akamatsu, Kiyonori Katsuragi, Hideaki Onishi, Midori Abe, Toru Hadama, Ayako Nishimura, Mio Ooguchi
-
Patent number: 8871518Abstract: A monoclonal antibody that does not show a crossreactivity with middle-molecular weight (MMW) adiponectin and specifically reacts with high-molecular weight (HMW) adiponectin alone is disclosed. The monoclonal antibody of the present invention can be produced by using HMW adiponectin as an antigen. According to the monoclonal antibody of the present invention, a convenient, high-accurate, and versatile reagent for analyzing HMW adiponectin can be provided.Type: GrantFiled: May 6, 2010Date of Patent: October 28, 2014Assignees: Otsuka Pharmaceutical Co., Ltd., LSI Medience CorporationInventors: Suguru Akamatsu, Kiyonori Katsuragi, Hideaki Onishi, Midori Abe, Toru Hadama, Ayako Nishimura, Mio Ooguchi
-
Publication number: 20130143253Abstract: The present invention provides a method for measuring the gastric acidity of a mammal using a 13C-labeled carbonate compound. Specifically, the present invention relates to a method for measuring the gastric acidity of a mammal including the following steps: (1) using, as a test sample, expired air of a mammalian subject excreted at any point in time within 30 minutes after oral administration of a predetermined amount of a 13C-labeled carbonate compound, measuring behavior of 13CO2 in the expired air; (2) comparing the behavior of 13CO2 (measured 13CO2 behavior) obtained in step (1) with the behavior of corresponding 13CO2 (reference 13CO2 behavior) that has been obtained beforehand in a control mammal; and (3) determining the gastric acidity of the mammalian subject based on a difference between the reference 13CO2 behavior and the measured 13CO2 behavior obtained above.Type: ApplicationFiled: August 18, 2011Publication date: June 6, 2013Inventors: Makoto Inada, Jun-ichi Kunizaki, Kazuki Tobita, Suguru Akamatsu, Shinji Iizuka
-
Patent number: 8241857Abstract: To provide an immunological detection method which can detect or quantify a pneumococcal antigen in a sample derived from a living body conveniently, rapidly, and with high sensitivity, and an antibody for use in the method. The present invention provides an antibody which specifically recognizes a pneumococcal F-antigen; a method for detecting or quantitating a pneumococcal antigen, characterized in that the method detects or quantitates a pneumococcal F-antigen in a sample derived from a living body through immunological assay employing the antibody; and a kit for detecting a pneumococcal antigen, the kit containing the antibody.Type: GrantFiled: March 31, 2009Date of Patent: August 14, 2012Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Suguru Akamatsu, Yoko Saijo
-
Publication number: 20120122245Abstract: Provided is a metal colloid having higher visibility and higher sensitivity than a gold colloid and a Au-core Pt-shell composite colloid and suitable as a labeling agent for use in a test such as an immunoassay. An alloyed Au/Pt composite colloid formed by mixing a gold salt and a platinum salt with at least one reducing agent selected from the group consisting of an amino acid and a derivative thereof, an oligopeptide and a derivative thereof, and an amino sugar in the presence of an alkali, thereby reducing the gold salt and platinum salt.Type: ApplicationFiled: July 29, 2010Publication date: May 17, 2012Applicants: Otsuka Pharmaceutical Co., Ltd., Kogakuin UniversityInventors: Masatoshi Watabe, Tetsuya Oda, Suguru Akamatsu
-
Publication number: 20120052596Abstract: A monoclonal antibody that does not show a crossreactivity with middle-molecular weight (MMW) adiponectin and specifically reacts with high-molecular weight (HMW) adiponectin alone is disclosed. The monoclonal antibody of the present invention can be produced by using HMW adiponectin as an antigen. According to the monoclonal antibody of the present invention, a convenient, high-accurate, and versatile reagent for analyzing HMW adiponectin can be provided.Type: ApplicationFiled: May 6, 2010Publication date: March 1, 2012Applicants: Otsuka Pharmaceutical Co., Ltd., Mitsubishi Chemical Medience CorporationInventors: Suguru Akamatsu, Kiyonori Katsuragi, Hideaki Onishi, Midori Abe, Toru Hadama, Ayako Nishimura, Mio Ooguchi
-
Publication number: 20110020848Abstract: To provide an immunological detection method which can detect or quantify a pneumococcal antigen in a sample derived from a living body conveniently, rapidly, and with high sensitivity, and an antibody for use in the method. The present invention provides an antibody which specifically recognizes a pneumococcal F-antigen; a method for detecting or quantitating a pneumococcal antigen, characterized in that the method detects or quantitates a pneumococcal F-antigen in a sample derived from a living body through immunological assay employing the antibody; and a kit for detecting a pneumococcal antigen, the kit containing the antibody.Type: ApplicationFiled: March 31, 2009Publication date: January 27, 2011Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Suguru Akamatsu, Yoko Saijo
-
Patent number: 7659125Abstract: A latex reagent for analyzing adiponectin, comprising a suspension of latex particles carrying a substance which specifically binds to adiponectin, is disclosed. Further, a method for analyzing adiponectin, comprising (1) obtaining a biological liquid possibly containing adiponectin, and (2) bringing the biological liquid, while maintaining the state in which the biological liquid is obtained, into contact with a suspension of latex particles carrying a substance which specifically binds to adiponectin, and optically analyzing a degree of latex-particles-agglutination, is disclosed. According to the latex reagent and the method for analyzing adiponectin, a predilution or pretreatment of the biological liquid to be analyzed is not necessary. Further, the analysis can be performed rapidly and conveniently, and facilities therefor are not limited.Type: GrantFiled: March 24, 2004Date of Patent: February 9, 2010Assignee: Mitsubishi Kagaku Latron, Inc.Inventors: Tetsuya Tachikawa, Suguru Akamatsu, Tokio Sawai, Ayako Nishimura
-
Publication number: 20070037207Abstract: A latex reagent for analyzing adiponectin, comprising a suspension of latex particles carrying a substance which specifically binds to adiponectin, is disclosed. Further, a method for analyzing adiponectin, comprising (1) obtaining a biological liquid possibly containing adiponectin, and (2) bringing the biological liquid, while maintaining the state in which the biological liquid is obtained, into contact with a suspension of latex particles carrying a substance which specifically binds to adiponectin, and optically analyzing a degree of latex-particles-agglutination, is disclosed. According to the latex reagent and the method for analyzing adiponectin, a predilution or pretreatment of the biological liquid to be analyzed is not necessary. Further, the analysis can be performed rapidly and conveniently, and facilities therefor are not limited.Type: ApplicationFiled: March 24, 2004Publication date: February 15, 2007Applicants: Mitsubishi Kagaku Iatron, Inc., Otsuka Pharmaceutical Co., Ltd.Inventors: Tetsuya Tachikawa, Suguru Akamatsu, Tokio Sawai, Ayako Nishimura