Abstract: A treatment method is provided which exhibits a reliable therapeutic effect on chronic obstructive pulmonary disease. In the treatment method, lung volume is reduced by restraining expansion and contraction of lung parenchyma present in the vicinity of a verge of a lung having an emphysema-suffering part, at least in one site of the verge.

Abstract: A fibrosis-causing agent is highly effective in the fibrosis of tissues. The fibrosis-causing agent contains a fibrosis inducer and a fibrosis promoter. A fibrosis-causing agent dosage form and a method of administering the fibrosis-causing agent is also disclosed.

Abstract: An implant assembly smoothly causes a folded implant to indwell a living body, and which can smoothly expand the implant without causing the implant to be displaced from a predetermined indwelling position when a filling material is injected. The implant assembly has the implant that is configured to be transformable from a folded and contracted state to an expanded state by the introduced filling material, and in which at least a portion of a surface thereof is covered with a covering material m whose friction coefficient increases by coming into contact with a body fluid, and guiding means for preventing the implant and the body fluid of the living body from coming into contact with each other inside the living body, and for guiding the implant to move to the indwelling position inside the living body.

Abstract: A fibrosis-causing agent is highly effective in the fibrosis of tissues. The fibrosis-causing agent contains a fibrosis inducer and a fibrosis promoter. A fibrosis-causing agent dosage form and a method of administering the fibrosis-causing agent is also disclosed.

Abstract: An implant assembly smoothly causes a folded implant to indwell a living body, and which can smoothly expand the implant without causing the implant to be displaced from a predetermined indwelling position when a filling material is injected. The implant assembly has the implant that is configured to be transformable from a folded and contracted state to an expanded state by the introduced filling material, and in which at least a portion of a surface thereof is covered with a covering material m whose friction coefficient increases by coming into contact with a body fluid, and guiding means for preventing the implant and the body fluid of the living body from coming into contact with each other inside the living body, and for guiding the implant to move to the indwelling position inside the living body.

Abstract: A medical device includes a tubular body having a first lumen so designed as to receive a fluid from an opening at one end of the first lumen and discharge the fluid from an opening at the other end of the first lumen, and an expandable body attached to the tubular body. The first lumen communicates with the space inside the expandable body and the expandable body expands by the internal pressure of the fluid which is injected from the opening at one end and enters the space inside the expandable body through the first lumen.

Abstract: Disclosed herein is a fibrosis-causing agent in a particulate form which effectively reduces the lung capacity in a noninvasive manner.

Abstract: A fibrosis-causing agent is highly effective in the fibrosis of tissues. The fibrosis-causing agent contains a fibrosis inducer and a fibrosis promoter. A fibrosis-causing agent dosage form and a method of administering the fibrosis-causing agent is also disclosed.

Abstract: A treatment method is provided which exhibits a reliable therapeutic effect on chronic obstructive pulmonary disease. In the treatment method, lung volume is reduced by restraining expansion and contraction of lung parenchyma present in the vicinity of a verge of a lung having an emphysema-suffering part, at least in one site of the verge.

Abstract: Disclosed herein is a method for alleviating the condition of spinal canal stenosis, including: transluminally placing a catheter in a lumbar artery, iliolumbar artery or lateral sacral artery at the proximity of a narrowed area of a spinal canal; and injecting a vasodilator into the artery via the catheter.

Abstract: A method for producing a fluorene derivative by reacting fluorenone with a phenol or a phenoxyalcohol in the presence of an acid catalyst includes: adding an alkali to an obtained reaction liquid containing a fluorene derivative; and concentrating a resultant mixture liquid without removing the alkali thus added and a reaction product of the alkali, thereby separating an unreacted phenol or unreacted phenoxyalcohol.

Abstract: An implant assembly includes an implant configured to be placed in a living body; an elongated body that includes a pulling unit, the pulling unit being configured such that a portion of the pulling unit is locatable outside the living body when the implant is placed in the living body, and the pulling unit being connectable to the implant and pullable to move the implant to a placement position; and a guide device configured to allow for an a percutaneous introduction of the elongated body into the living body.

Abstract: An object of the present invention is to provide (i) a novel non-crystalline form of 9,9-bis(4-(2-hydroxyethoxy) phenyl) fluorene, which non-crystalline form maintains quality at a certain level, and is excellent as a polymer material, and (ii) a method of preparing the non-crystalline form. According to the present invention, molten 9,9-bis(4-(2-hydroxyethoxy) phenyl) fluorene in a liquid form is cooled and therefore is solidified. With the method, it is possible to provide a novel non-crystalline form of 9,9-bis(4-(2-hydroxyethoxy) phenyl) fluorene which has a small risk that powder dust of 9,9-bis(4-(2-hydroxyethoxy) phenyl) fluorine might cause explosion or a health problem. Further, the non-crystalline form of 9,9-bis(4-(2-hydroxyethoxy) phenyl) fluorene can be adjusted arbitrarily in particle diameter by, for example, pulverizing the non-crystalline form in accordance with equipment or usage.

Abstract: A method for improving the blood flow in the bone head, the method including the steps of extending a long tubular body, which has a cutting tool at its foreend, close to the entrance of the retinaculum artery and performing drilling on the bone head by using the cutting tool. This method makes it possible to improve the blood flow in the bone head with a minimum of burden on the patient.

Abstract: A medical device includes a tubular body having a first lumen so designed as to receive a fluid from an opening at one end of the first lumen and discharge the fluid from an opening at the other end of the first lumen, and an expandable body attached to the tubular body. The first lumen communicates with the space inside the expandable body and the expandable body expands by the internal pressure of the fluid which is injected from the opening at one end and enters the space inside the expandable body through the first lumen.

Abstract: Disclosed herein is a method for alleviating the condition of spinal canal stenosis, including: transluminally placing a catheter in a lumbar artery, iliolumbar artery or lateral sacral artery at the proximity of a narrowed area of a spinal canal; and injecting a vasodilator into the artery via the catheter.

Abstract: Disclosed is a method for dilating between spinous processes wherein a filamentous body provided with an expansion body is percutaneously inserted to locate the expansion body between the spinous processes, a filling material is injected into the expansion body to dilate between the spinous processes, and the expansion body is cut off from the filamentous body to be located between the spinous processes. This method exerts very little burden on the patient.

Abstract: An object of the present invention is to provide (i) a novel non-crystalline form of 9,9-bis(4-(2-hydroxyethoxy)phenyl)fluorene, which non-crystalline form maintains quality at a certain level, and is excellent as a polymer material, and (ii) a method of preparing the non-crystalline form. According to the present invention, molten 9,9-bis(4-(2-hydroxyethoxy)phenyl)fluorene in a liquid form is cooled and therefore is solidified. With the method, it is possible to provide a novel non-crystalline form of 9,9-bis(4-(2-hydroxyethoxy)phenyl)fluorene which has a small risk that powder dust of 9,9-bis(4-(2-hydroxyethoxy)phenyl)fluorene might cause explosion or a health problem. Further, the non-crystalline form of 9,9-bis(4-(2-hydroxyethoxy)phenyl)fluorene can be adjusted arbitrarily in particle diameter by, for example, pulverizing the non-crystalline form in accordance with equipment or usage.

Abstract: A method for producing a fluorene derivative by reacting fluorenone with a phenol or a phenoxyalcohol in the presence of an acid catalyst includes: adding an alkali to an obtained reaction liquid containing a fluorene derivative; and concentrating a resultant mixture liquid without removing the alkali thus added and a reaction product of the alkali, thereby separating an unreacted phenol or unreacted phenoxyalcohol.