Abstract: A coating agent can be applied to various materials without using radiation, and a medical material using the same. The coating agent containing a copolymer that contains: a monomer unit (unit A) containing a Si—O bond; a vinyl carboxylate monomer unit (unit B); and a monomer unit (unit C) containing a hydrophilic group.

Abstract: A separation membrane module includes a case and a separation membrane built in the case, wherein the separation membrane module satisfies the following requirements (1) to (3): (1) the separation membrane contains a hydrophobic polymer, a hydrophilic polymer, and a biocompatible copolymer, the hydrophilic polymer containing a hydrophilic polymer having mobility, (2) the separation membrane contains the hydrophilic polymer having mobility in a range of 1.0 to 1.7% by mass, and (3) a water content per self-weight of the separation membrane is in a range of 0 to 10% by mass. The separation membrane module is provided in which fouling of a membrane is suppressed and the amount of eluted substance is small.

Abstract: Disclosed is a porous hollow fiber membrane containing a polysulfone-based polymer as a main component, which has an asymmetric structure in which the inner surface side is dense and the outer surface side is coarse, wherein an average of a minor axis diameter of pores of an inner surface is 20 nm or more and 40 nm or less, an open porosity of the inner surface is 10% or more and 30% or less, and a polymer including a monocarboxylic acid vinyl ester unit is supported on at least one of the outer surface and the inner surface. The present invention provides a hollow fiber membrane which has excellent removing performance of substances to be separated such as viruses, and can be used as a separation membrane having high permeability even in a treatment under low pressure.

Abstract: A separation membrane module includes a separation membrane including a hydrophobic polymer, a hydrophilic polymer, and polymer A, wherein the polymer A includes a hydrophilic unit and a hydrophobic unit, and is a copolymer having an alkyl group having 2 to 20 carbon atoms at a side-chain terminal of the hydrophobic unit, the separation membrane module having a retention rate of an albumin sieving coefficient of 86% or more at 60 minutes after circulation start relative to an albumin sieving coefficient at 10 minutes after circulation start when 2 L of bovine blood containing 50 U/ml of heparin, and having a hematocrit of 30% by volume and a total protein concentration of 6 to 7 g/dl is circulated at a flow rate of 100 ml/min at 37° C. and a filtration flow rate of 10 ml/(min·m2).

Abstract: A copolymer is capable of being immobilized on a base material while maintaining a high antithrombotic property persistently without having to introduce heparin or an anticoagulant drug to the surface thereof. The copolymer includes monomer unit A, monomer unit B, and monomer unit C, wherein monomer unit C has a mole fraction of 0.5-40% with respect to the total amount of all constituent monomer units.

Abstract: A biological component adhesion-suppressing material includes a substrate provided with a functional layer having, fixed on a surface thereof that comes into contact with a biological component, a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit, wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device, the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.

Abstract: A medical material is capable of suppressing adhesion of platelets and proteins even when in contact with biological components such as blood for an extended period of time. The medical material is a copolymer including hydrophobic units and hydrophilic units in which the hydrophobic units have a C2-20 terminal alkyl group in a side chain, the static contact angle of water in the copolymer is at least 30° and less than 70°, and the glass transition temperature of the copolymer exists at only one point in the range from 45° C. to less than 90° C.

Abstract: A biological component adhesion-suppressing material includes a substrate provided with a functional layer having, fixed on a surface thereof that comes into contact with a biological component, a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit, wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device, the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.

Abstract: A copolymer is excellent in water permeability, suppression of platelet adhesion, and suppression of protein adhesion, and a separation membrane, a medical device, and a separation membrane module for medical use using the copolymer. The copolymer includes monomer units derived from two or more types of monomers, wherein the hydration energy density of the copolymer is 158.992 to 209.200 kJ·mol?1·nm?3, the monomer unit with the highest hydration energy density in the monomer units is a monomer unit not containing a hydroxy group, the volume fraction of the monomer unit with the highest hydration energy density in the monomer units is 35 to 90%, and the difference in hydration energy density is 71.128 to 418.400 kJ·mol?1·nm?3.

Abstract: A copolymer is capable of being immobilized on a base material while maintaining a high antithrombotic property persistently without having to introduce heparin or an anticoagulant drug to the surface thereof. The copolymer includes monomer unit A, monomer unit B, and monomer unit C, wherein monomer unit C has a mole fraction of 0.5-40% with respect to the total amount of all constituent monomer units.

Abstract: A medical material is capable of suppressing adhesion of platelets and proteins even when in contact with biological components such as blood for an extended period of time. The medical material is a copolymer including hydrophobic units and hydrophilic units in which the hydrophobic units have a C2-20 terminal alkyl group in a side chain, the static contact angle of water in the copolymer is at least 30° and less than 70°, and the glass transition temperature of the copolymer exists at only one point in the range from 45° C. to less than 90° C.

Abstract: A copolymer has blood compatibility and antithrombotic properties of greatly suppressing protein adhesion to be usable even when in contact with a biological component such as blood for a long period of time, and a medical device uses the copolymer. The copolymer is characterized by including a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit contains at least one type of a carboxylic acid vinyl unit, and the number of carbon atoms at the terminal of a side chain of the carboxylic acid vinyl unit is 2-7.

Abstract: A copolymer has blood compatibility and antithrombotic properties of greatly suppressing protein adhesion to be usable even when in contact with a biological component such as blood for a long period of time, and a medical device uses the copolymer. The copolymer is characterized by including a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit contains at least one type of a carboxylic acid vinyl unit, and the number of carbon atoms at the terminal of a side chain of the carboxylic acid vinyl unit is 2-7.