Patents by Inventor Suhail Ayesh

Suhail Ayesh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detection of micro-metastasis
    Publication number: 20060121477
    Abstract: The present invention concerns a method for the identification of micro-metastasis or residual cancer cells, by identifying the presence of H19 in a sample.
    Type: Application
    Filed: September 12, 2003
    Publication date: June 8, 2006
    Inventors: Abraham Hochberg, Suhail Ayesh
  • Methods and compositions for inducing tumor-specific cytotoxicity
    Patent number: 7041654
    Abstract: The present invention relates to the tumor-specific expression of heterologous polynucleotides, particularly genes encoding cytotoxic products, under the control of transcriptional regulatory sequences. Particularly preferred transcriptional regulatory sequences comprise H19, IGF-1 and IGF-2 P4 transcriptional regulatory sequences, and variants thereof. The present invention also provides expression constructs and methods of administering such expression constructs. The compositions and methods of the invention are useful for the treatment of proliferative disorders, particularly cancer.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: May 9, 2006
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Abraham Hochberg, Suhail Ayesh
  • Methods and compositions for inducing tumor-specific cytotoxicity
    Publication number: 20040082529
    Abstract: The present invention relates to the tumor-specific expression of heterologous polynucleotides, particularly genes encoding cytotoxic products, under the control of transcriptional regulatory sequences. Particularly preferred transcriptional regulatory sequences comprise H19, IGF-1 and IGF-2 P4 transcriptional regulatory sequences, and variants thereof. The present invention also provides expression constructs and methods of administering such expression constructs. The compositions and methods of the invention are useful for the treatment of proliferative disorders, particularly cancer.
    Type: Application
    Filed: October 22, 2001
    Publication date: April 29, 2004
    Inventors: Abraham Hochberg, Suhail Ayesh
  • Methods and compositions for inducing tumor-specific cytotoxicity
    Patent number: 6306833
    Abstract: The invention relates to the specific expression of heterologous sequences, particularly genes encoding cytotoxic products, in tumor cells under the control of regulatory transcriptional sequences. Particularly preferred promoters include H19 regulatory sequences, the IGF-1 promoter and the IGF-2 P3 and P4 promoters. The invention provides expression constructs and methods of administering such expression constructs. The compositions and methods of the invention are useful in the treatment of cancer.
    Type: Grant
    Filed: May 10, 2000
    Date of Patent: October 23, 2001
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Abraham Hochberg, Suhail Ayesh
  • Methods and compositions for inducing tumor-specific cytotoxicity
    Patent number: 6087164
    Abstract: The invention relates to the specific expression of heterologous sequences, particularly genes encoding cytotoxic products, in tumor cells under the control of regulatory transcriptional sequences. Particularly preferred promoters include H19 regulatory sequences, the IGF-1 promoter and the IGF-2 P3 and P4 promoters. The invention provides expression constructs and methods of administering such expression constructs. The compositions and methods of the invention are useful in the treatment of cancer.
    Type: Grant
    Filed: October 1, 1998
    Date of Patent: July 11, 2000
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Abraham Hochberg, Suhail Ayesh