Patents by Inventor Sui Huang

Sui Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200009146
    Abstract: The invention provides a compound of formula (I): wherein R1, R2, R3, and R4 are as defined herein, ginsenoside Rg2 of structure (II): or a combination thereof, for use in treating or preventing a condition responsive to the induction of autophagy in a brain of a mammal in need thereof.
    Type: Application
    Filed: January 25, 2018
    Publication date: January 9, 2020
    Applicants: Northwestern University, The United States of America, as Represented by the Secretary, Department of Health & Human Services, University of Kansas
    Inventors: Congcong HE, Sui HUANG, Chen WANG, Altea ROCCHI, Juan Jose MARUGAN, Marc FERRER, Samarjit PATNAIK, Yuchi CHEN, Kevin FRANKOWSKI, Frank J. SCHOENEN
  • Publication number: 20190374485
    Abstract: Provided herein are compositions and methods for treating, ameliorating, or preventing hepatocellular carcinoma in patients. In particular, the invention relates to methods of treating, ameliorating, or preventing hepatocellular carcinoma in a patient, comprising administering to the patient 6-methoxyethylamino-numonafide alone or in combination with sorafenib.
    Type: Application
    Filed: July 18, 2019
    Publication date: December 12, 2019
    Inventors: Sui Huang, Zhi Chen, Yanning Liu, John T. Norton, Chen Wang, Guohua Lou, Richard M. Green
  • Patent number: 10301314
    Abstract: The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: May 28, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Kansas, Northwestern University
    Inventors: Kevin Frankowski, Samarjit Patnaik, Sui Huang, Juan Jose Marugan, John Norton, Frank J. Schoenen, Noel Terrence Southall, Steven Titus, Wei Zheng, Chen Wang
  • Publication number: 20190012596
    Abstract: The present disclosure provides a data processing system, method and device. The system includes a control component and a plurality of computing subcomponents coupled to the control component. The plurality of computing subcomponents respectively processes sample subsets of a sample data set under instruction of a processing procedure in the control component. For one of the plurality of computing subcomponents, at least one data element is configured to output the sample subsets of the sample data set in sequence to an embedding element based on the processing procedure in the control component. At least one embedding element is configured to receive a sample subset based on the processing procedure in the control component, map sample data in the sample subset to a multi-dimensional space based on a mapping parameter to obtain a multi-dimensional sample subset, and output the multi-dimensional sample subset to at least one backend element.
    Type: Application
    Filed: July 6, 2018
    Publication date: January 10, 2019
    Inventors: Kun GAI, Xingya DAI, Zelin HU, Sui HUANG, Bochao LIU, Chengru SONG, Peng SUN, Zhi WANG, Yanghui YAN, Huimin YI, Yu ZHANG, Liqin ZHAO, Guorui ZHOU, Xiaoqiang ZHU
  • Publication number: 20180110743
    Abstract: Provided herein are compositions and methods for treating, ameliorating, or preventing hepatocellular carcinoma in patients. In particular, the invention relates to methods of treating, ameliorating, or preventing hepatocellular carcinoma in a patient, comprising administering 6-methoxyethylamino-numonafide alone or in combination with sorafenib.
    Type: Application
    Filed: March 18, 2016
    Publication date: April 26, 2018
    Applicant: Northwestern University
    Inventors: Sui Huang, Zhi Chen, Yanning Liu, John T. Norton, Chen Wang, Guohua Lou, Richard M. Green
  • Patent number: 9878984
    Abstract: The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: January 30, 2018
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Sui Huang, John Norton, Daniel Appella, Mark Witschi
  • Publication number: 20170260192
    Abstract: The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.
    Type: Application
    Filed: May 26, 2017
    Publication date: September 14, 2017
    Applicants: The United States of America, as represented by the Secretary, Dept of Health and Human Services, University of Kansas, Northwestern University
    Inventors: Kevin Frankowski, Samarjit Patnaik, Sui Huang, Juan Jose Marugan, John Norton, Frank J. Schoenen, Noel Terrence Southall, Steven Titus, Wei Zheng
  • Patent number: 9663521
    Abstract: The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: May 30, 2017
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Kansas, Northwestern University
    Inventors: Kevin Frankowski, Samarjit Patnaik, Sui Huang, Juan Jose Marugan, John Norton, Frank J. Schoenen, Noel Terrence Southall, Steven Titus, Wei Zheng
  • Patent number: 9525544
    Abstract: A full-rate referenceless clock-data recovery architecture with neither a frequency detector nor a lock detector that allows both frequency and phase locking in a single loop. According to one embodiment, a referenceless clock data recovery (CDR) circuit, comprises a digital control circuit (DCC), a phase and strobe point detector circuit (PSPD), and an LC voltage control oscillator (LC VCO) electrically coupled to the PSPD and DCC such that a frequency of the LC VCO decreases when a negative strobe point is detected and an initial frequency of the LC VCO is higher than an input data bit rate.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: December 20, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michael M. Green, Sui Huang
  • Publication number: 20160109456
    Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
    Type: Application
    Filed: October 15, 2015
    Publication date: April 21, 2016
    Inventors: Sui Huang, Rajesh V. Kamath, David L. Spector, Ann D. Thor, Chen Wang
  • Publication number: 20150349945
    Abstract: A full-rate referenceless clock-data recovery architecture with neither a frequency detector nor a lock detector that allows both frequency and phase locking in a single loop. According to one embodiment, a referenceless clock data recovery (CDR) circuit, comprises a digital control circuit (DCC), a phase and strobe point detector circuit (PSPD), and an LC voltage control oscillator (LC VCO) electrically coupled to the PSPD and DCC such that a frequency of the LC VCO decreases when a negative strobe point is detected and an initial frequency of the LC VCO is higher than an input data bit rate.
    Type: Application
    Filed: May 19, 2015
    Publication date: December 3, 2015
    Inventors: Michael M. Green, Sui Huang
  • Publication number: 20140378503
    Abstract: The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
    Type: Application
    Filed: September 8, 2014
    Publication date: December 25, 2014
    Inventors: Sui Huang, John Norton, Daniel Appella, Mark Witschi
  • Publication number: 20140323438
    Abstract: The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.
    Type: Application
    Filed: December 17, 2012
    Publication date: October 30, 2014
    Inventors: Kevin Frankowski, Samarjit Patnaik, Sui Huang, Juan Jose Marugan, John Norton, Frank J. Schoenen, Noel Terrence Southall, Steven Titus, Wei Zheng
  • Patent number: 8829025
    Abstract: The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: September 9, 2014
    Assignee: Northwestern University
    Inventors: Sui Huang, John Norton, Daniel Appella, Mark Witschi
  • Publication number: 20130225634
    Abstract: The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
    Type: Application
    Filed: March 29, 2013
    Publication date: August 29, 2013
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Sui Huang, John Norton, Daniel Appella, Mark Witschi
  • Patent number: 8420665
    Abstract: The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
    Type: Grant
    Filed: January 12, 2009
    Date of Patent: April 16, 2013
    Assignee: Northwestern University
    Inventors: Sui Huang, John Norton, Daniel Appella, Mark Witschl
  • Publication number: 20120309017
    Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
    Type: Application
    Filed: August 14, 2012
    Publication date: December 6, 2012
    Applicants: COLD SPRING HARBOR LABORATORY, NORTHWESTERN UNIVERSITY
    Inventors: Sui Huang, Rajesh V. Kamath, David L. Spector, Ann D. Thor, Chen Wang
  • Patent number: 8241862
    Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: August 14, 2012
    Assignees: Northwestern University, Cold Spring Harbor Laboratory
    Inventors: Sui Huang, Rajesh V. Kamath, David L. Spector, Ann D. Thor, Chen Wang
  • Publication number: 20100303719
    Abstract: The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
    Type: Application
    Filed: January 12, 2009
    Publication date: December 2, 2010
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Sui Huang, John Norton, Daniel Appella, Mark Witschi
  • Patent number: 7834884
    Abstract: A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference elements; assigning a respective value to each respective tile of the spatial layout of the representative elements; and displaying an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: November 16, 2010
    Assignee: Children's Medical Center Corporation
    Inventors: Donald E. Ingber, Sui Huang, Gabriel Eichler