Patents by Inventor Sujal M. Patel

Sujal M. Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11282586
    Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: March 22, 2022
    Assignee: NAUTILUS BIOTECHNOLOGY, INC.
    Inventors: Sujal M. Patel, Parag Mallick, Jarrett D. Egertson
  • Patent number: 11282585
    Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: March 22, 2022
    Assignee: NAUTILUS BIOTECHNOLOGY, INC.
    Inventors: Sujal M. Patel, Parag Mallick, Jarrett D. Egertson
  • Publication number: 20220068431
    Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.
    Type: Application
    Filed: April 2, 2021
    Publication date: March 3, 2022
    Inventors: Sujal M. Patel, Parag Mallick, Jarrett D. Egertson
  • Publication number: 20220050049
    Abstract: The present disclosure provides methods and systems for performing single-molecule detection using fabricated integrated on-chip devices.
    Type: Application
    Filed: October 28, 2021
    Publication date: February 17, 2022
    Inventors: Pierre INDERMUHLE, Elliott SORELLE, David STERN, Parag MALLICK, Sujal M. PATEL
  • Publication number: 20220017567
    Abstract: The methods described herein provide a means of producing an array of spatially separated proteins. The method relies on covalently attaching each protein of the plurality of proteins to a structured nucleic acid particle (SNAP), and attaching the SNAPs to a solid support.
    Type: Application
    Filed: October 7, 2021
    Publication date: January 20, 2022
    Inventors: Dmitriy GREMYACHINSKIY, Rachel GALIMIDI, Parag MALLICK, Sujal M. PATEL
  • Patent number: 11203612
    Abstract: The methods described herein provide a means of producing an array of spatially separated proteins. The method relies on covalently attaching each protein of the plurality of proteins to a structured nucleic acid particle (SNAP), and attaching the SNAPs to a solid support.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: December 21, 2021
    Assignee: Nautilus Biotechnology, Inc.
    Inventors: Dmitriy Gremyachinskiy, Rachel Galimidi, Parag Mallick, Sujal M. Patel
  • Publication number: 20210390705
    Abstract: The present disclosure provides systems and methods for detecting components of an array of biological, chemical, or physical entities. In an aspect, the present disclosure provides a method for detecting an array of biological, chemical, or physical entities, comprising: (a) using one or more light sensing devices, acquiring pixel information from sites in an array, wherein the sites comprise biological, chemical, or physical entities that produce light; (b) processing the pixel information to identify a set of regions of interest (ROIs) corresponding to the sites in the array that produce the light; (c) classifying the pixel information for the ROIs into a categorical classification from among a plurality of distinct categorical classifications, thereby producing a plurality of pixel classifications; and (d) identifying one or more components of the array of biological, chemical, or physical entities based at least in part on the plurality of pixel classifications.
    Type: Application
    Filed: June 10, 2021
    Publication date: December 16, 2021
    Inventors: Jarrett D. EGERTSON, Vadim LOBANOV, David STERN, Parag MALLICK, Sujal M. PATEL, Ryan K. SEGHERS
  • Publication number: 20210358563
    Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.
    Type: Application
    Filed: July 28, 2021
    Publication date: November 18, 2021
    Inventors: Sujal M. PATEL, Parag MALLICK, Jarrett D. EGERTSON
  • Publication number: 20210358562
    Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.
    Type: Application
    Filed: July 28, 2021
    Publication date: November 18, 2021
    Inventors: Sujal M. PATEL, Parag MALLICK, Jarrett D. EGERTSON
  • Publication number: 20210304839
    Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.
    Type: Application
    Filed: April 2, 2021
    Publication date: September 30, 2021
    Inventors: Sujal M. PATEL, Parag MALLICK, Jarrett D. EGERTSON
  • Publication number: 20210101930
    Abstract: The methods described herein provide a means of producing an array of spatially separated proteins. The method relies on covalently attaching each protein of the plurality of proteins to a structured nucleic acid particle (SNAP), and attaching the SNAPs to a solid support.
    Type: Application
    Filed: October 2, 2020
    Publication date: April 8, 2021
    Inventors: Dmitriy GREMYACHINSKIY, Rachel GALIMIDI, Parag MALLICK, Sujal M. PATEL
  • Publication number: 20200286584
    Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.
    Type: Application
    Filed: August 7, 2019
    Publication date: September 10, 2020
    Inventors: Sujal M. PATEL, Parag MALLICK, Jarrett D. EGERTSON
  • Publication number: 20200090785
    Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.
    Type: Application
    Filed: August 7, 2019
    Publication date: March 19, 2020
    Inventors: Sujal M. PATEL, Parag MALLICK, Jarrett D. EGERTSON
  • Publication number: 20200082914
    Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for iteratively identifying candidate proteins within a sample of unknown proteins, the method comprising receiving information of binding measurements of each of a plurality of affinity reagent probes to the unknown proteins, each affinity reagent probe configured to selectively bind to one or more candidate proteins; comparing at least a portion of the information of binding measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein; and iteratively generating a probability that each of one or more candidate proteins is present in the sample based on the comparison of the information of binding measurements of the candidate proteins against the database comprising the plurality of protein sequences.
    Type: Application
    Filed: August 7, 2019
    Publication date: March 12, 2020
    Inventors: Sujal M. PATEL, Parag MALLICK, Jarrett D. EGERTSON
  • Patent number: 9967189
    Abstract: A system and a method determine network conditions. The system includes a server computer and a client computer. The server computer is configured to transmit data packets comprising a data object from the server computer to the client computer. The client computer includes a transmission latency detector and a transmission bandwidth detector. The transmission latency detector uses transmission time and receipt time values to determine the changes in time it takes selected portions of the data object to be transmitted from the server computer to the client computer. The transmission bandwidth detector uses identified back-to-back data packets to determine the transmission bandwidth between the server computer and the client computer.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: May 8, 2018
    Assignee: Intel Corporation
    Inventors: Sujal M. Patel, Jeffrey M. Ayars, Rahul Agarwal, Bradley D. Hefta-Gaub, Peter S. Haight, Dale R. Stammen, Philip Rosedale
  • Patent number: 8812717
    Abstract: A system and method provide random access to a multimedia object over a network. One embodiment of the invention includes a streaming media server that is connected to a client computer over a network. The streaming media server includes at least one multimedia object that is adapted for transmission (“streaming”) across the network. A pre-roll calculation program determines a pre-roll for each segment of the multimedia object and generates a modified multimedia object which includes a pre-roll for each of its segments, a pre-roll identifying a portion of the multimedia object to be transmitted by the streaming media server and received by the client computer prior to playback of the multimedia object at a selected segment. The pre-roll allows the client computer to present, starting at a selected segment, the multimedia object in its entirety without interruption.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: August 19, 2014
    Assignee: Intel Corporation
    Inventors: Rahul Agarwal, Jeffrey M. Ayars, Bradley D. Hefta-Gaub, Gary S. Greenbaum, Alan F. Lippman, Sujal M. Patel, Dale R. Stammen, Philip Rosedale, Bryan Vergato
  • Patent number: 8706755
    Abstract: A distributed file system enables the intelligent storing and retrieval of files among a plurality of storage units. The distributed file system utilizes a metadata data structure to track and manage detailed information about each file, including, for example, the device and block locations of the file's data blocks, to permit different levels of replication and/or redundancy. The distributed file system includes a switch to receive a read request for a file and to send the read request to one of the storage units. Each of the plurality of storage units is operable to monitor access to the file, such that a block cache module is operable to perform a scalable number of packet read aheads, wherein the scalable number is based on at least a current read rate and a current latency of a link to access the at least one file.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: April 22, 2014
    Assignee: EMC Corporation
    Inventors: Sujal M. Patel, Paul A. Mikesell, Darren P. Schack
  • Publication number: 20130117463
    Abstract: A system and method provide random access to a multimedia object over a network. One embodiment of the invention includes a streaming media server that is connected to a client computer over a network. The streaming media server includes at least one multimedia object that is adapted for transmission (“streaming”) across the network. A pre-roll calculation program determines a pre-roll for each segment of the multimedia object and generates a modified multimedia object which includes a pre-roll for each of its segments, a pre-roll identifying a portion of the multimedia object to be transmitted by the streaming media server and received by the client computer prior to playback of the multimedia object at a selected segment. The pre-roll allows the client computer to present, starting at a selected segment, the multimedia object in its entirety without interruption.
    Type: Application
    Filed: December 27, 2012
    Publication date: May 9, 2013
    Inventors: RAHUL AGARWAL, JEFFREY M. AYARS, BRADLEY D. HEFTA-GAUB, GARY S. GREENBAUM, ALAN F. LIPPMAN, SUJAL M. PATEL, DALE R. STAMMEN, PHILIP ROSEDALE, BRYAN VERGATO
  • Patent number: 8356108
    Abstract: A system and method provide random access to a multimedia object over a network. One embodiment of the invention includes a streaming media server that is connected to a client computer over a network. The streaming media server includes at least one multimedia object that is adapted for transmission (“streaming”) across the network. A pre-roll calculation program determines a pre-roll for each segment of the multimedia object and generates a modified multimedia object which includes a pre-roll for each of its segments, a pre-roll identifying a portion of the multimedia object to be transmitted by the streaming media server and received by the client computer prior to playback of the multimedia object at a selected segment. The pre-roll allows the client computer to present, starting at a selected segment, the multimedia object in its entirety without interruption.
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: January 15, 2013
    Assignee: Intel Corporation
    Inventors: Rahul Agarwal, Jeffrey M. Ayars, Bradley D. Hefta-Gaub, Gary S. Greenbaum, Alan F. Lippman, Sujal M. Patel, Dale R. Stammen, Philip Rosedale, Bryan Vergato
  • Patent number: 8112395
    Abstract: The intelligent distributed file system enables the storing of file data among a plurality of smart storage units which are accessed as a single file system. The intelligent distributed file system utilizes a metadata data structure to track and manage detailed information about each file, including, for example, the device and block locations of the file's data blocks, to permit different levels of replication and/or redundancy within a single file system, to facilitate the change of redundancy parameters, to provide high-level protection for metadata, to replicate and move data in real-time, and so forth.
    Type: Grant
    Filed: May 25, 2010
    Date of Patent: February 7, 2012
    Assignee: EMC Corporation
    Inventors: Sujal M. Patel, Paul A. Mikesell, Darren P. Schack