Abstract: Compositions and methods are provided for rapid and efficient production of antibodies in vitro as well as in vivo, which may be used to neutralize antigens. More specifically, the present invention relates to scaffolds comprised of amphiphilic multiblock copolymers that can form micelles based on nonionic or amphiphilic core blocks as well as ionic blocks, and with an antigen and methods of crosslinking B cell receptors to specifically produce antibodies against the antigen in vitro as well as in vivo in a more efficient method than other available monoclonal antibody production method.