Patents by Inventor Sujeewa Ranatunga Mahanthe MUDIYANSELAGE

Sujeewa Ranatunga Mahanthe MUDIYANSELAGE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4
    Publication number: 20230234924
    Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and sternness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit sternness. Disclosed are compounds that affect the Yap1:Oct4 interaction.
    Type: Application
    Filed: December 19, 2022
    Publication date: July 27, 2023
    Inventors: Srikumar CHELLAPPAN, Nicholas J. LAWRENCE, Sujeewa Ranatunga Mahanthe MUDIYANSELAGE
  • YAP1 inhibitors that target the interaction of YAP1 with OCT4
    Patent number: 11685725
    Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and sternness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit sternness. Disclosed are compounds that affect the Yap1:Oct4 interaction.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: June 27, 2023
    Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
    Inventors: Srikumar Chellappan, Nicholas J. Lawrence, Sujeewa Ranatunga Mahanthe Mudiyanselage
  • YAP1 inhibitors that target the interaction of YAP1 with Oct4
    Patent number: 11530182
    Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and stemness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit sternness. Disclosed are compounds that affect the Yap1:Oct4 interaction.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: December 20, 2022
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Srikumar Chellappan, Nicholas J. Lawrence, Sujeewa Ranatunga Mahanthe Mudiyanselage
  • YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4
    Publication number: 20210363128
    Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and sternness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit sternness. Disclosed are compounds that affect el the Yap1:Oct4 interaction.
    Type: Application
    Filed: March 14, 2019
    Publication date: November 25, 2021
    Inventors: Srikumar CHELLAPPAN, Nicholas J. LAWRENCE, Sujeewa Ranatunga Mahanthe MUDIYANSELAGE
  • YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4
    Publication number: 20210130297
    Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and stemness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit sternness. Disclosed are compounds that affect the Yap1:Oct4 interaction.
    Type: Application
    Filed: December 30, 2020
    Publication date: May 6, 2021
    Inventors: Srikumar CHELLAPPAN, Nicholas J. LAWRENCE, Sujeewa Ranatunga Mahanthe MUDIYANSELAGE
  • YAP1 inhibitors that target the interaction of YAP1 with OCT4
    Patent number: 10906874
    Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WAV domain could prevent the induction of Sox2 and stemness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit stemness. Disclosed are compounds that affect the Yap1:Oct4 interaction.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: February 2, 2021
    Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
    Inventors: Srikumar Chellappan, Nicholas J. Lawrence, Sujeewa Ranatunga Mahanthe Mudiyanselage
  • YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4
    Publication number: 20190375709
    Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2. which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WAV domain could prevent the induction of Sox2 and stemness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit stemness. Disclosed arc compounds that affect the Yap1:Oct4 interaction.
    Type: Application
    Filed: September 18, 2017
    Publication date: December 12, 2019
    Inventors: Srikumar CHELLAPAN, Nicholas J. LAWRENCE, Sujeewa Ranatunga Mahanthe MUDIYANSELAGE