Abstract: The present disclosure relates to devices and methods for forming microfibers, and organoids useful in cell-culture. In embodiments, a method of forming one or more microfibers, includes: flowing a hydrogel agent through a conduit from a first reservoir to a second reservoir including a crosslinking agent under conditions suitable for forming one or more microfibers within the second reservoir, wherein flowing includes pulling the hydrogel agent into the second reservoir through the conduit, wherein the first reservoir, the conduit, and the second reservoir are in fluid communication. In embodiments, the conduit includes one or more needles in fluid communication with the second reservoir.