Patents by Inventor Sujuan Sun

Sujuan Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A PEPTIDE WITH DISULFIDE BONDS AND INHIBITORY ACTIVITY AGAINST SERINE PROTEASES, DERIVED HYBRID PEPTIDES THEREOF, AND USES THEREOF
    Publication number: 20230416329
    Abstract: Provided are a polypeptide containing disulfide bonds and capable of inhibiting activity of serine protease, and a use thereof, relating to three types of linear polypeptide molecules, respectively capable of inhibiting the activity of small intestine protein metabolic enzymes such as trypsin, chymotrypsin, and elastase. Said polypeptide molecules may be broadly fused to another polypeptide or protein drug capable of treating a disease, so as to form a hybrid peptide. The hybrid peptide may inhibit the degradation of metabolic enzymes to improve the stability of a peptide or protein drug for treating a disease, such that the curative effect of direct injection administration is improved, while also facilitating direct administration absorption of the polypeptide or protein drug in the small intestine, and implementing oral administration of the protein polypeptide drug.
    Type: Application
    Filed: November 29, 2021
    Publication date: December 28, 2023
    Inventors: Wei WANG, Zhufang SHEN, Minzhi LIU, Caina LI, Sujuan SUN, Ying MA, Hui CAO, Haijing ZHANG, Yan YANG, Lianqiu WU
  • Use of the effective fraction of alkaloids from mulberry twig in preparing hypoglycemic agents
    Patent number: 9066960
    Abstract: The present invention relates to an effective fraction of alkaloids and the effective fraction is prepared from mulberry twig and its active ingredients are a composition of alkaloids. Determined by HPLC, the percentage of the total alkaloids are 50% or more by weight in the effective fraction and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids. The effective fraction of the invention is prepared as the following steps: the mulberry twig is extracted by solvents, and the extract is precipitated by alcohol precipitation or flocculation to remove the impurities, and then concentrated, purified by resin chromatography. The present invention also relates to a pharmaceutical composition containing the said effective fraction of alkaloids and to the use of the effective fraction of alkaloids according to claim 1-4 in preparing hypoglycemic agents.
    Type: Grant
    Filed: August 22, 2007
    Date of Patent: June 30, 2015
    Assignee: INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES
    Inventors: Yuling Liu, Zhufang Shen, Zhen Chen, Renyun Wang, Xuejun Xia, Yueteng Chen, Quan Liu, Sujuan Sun, Mingzhi Xie
  • THE USE OF THE EFFECTIVE FRACTION OF ALKALOIDS FROM MULBERRY TWIG IN PREPARING HYPOGLYCEMIC AGENTS
    Publication number: 20110130352
    Abstract: The present invention relates to an effective fraction of alkaloids and the effective fraction is prepared from mulberry twig and its active ingredients are a composition of alkaloids. Determined by HPLC, the percentage of the total alkaloids are 50% or more by weight in the effective fraction and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids. The effective fraction of the invention is prepared as the following steps: the mulberry twig is extracted by solvents, and the extract is precipitated by alcohol precipitation or flocculation to remove the impurities, and then concentrated, purified by resin chromatography. The present invention also relates to a pharmaceutical composition containing the said effective fraction of alkaloids and to the use of the effective fraction of alkaloids according to claim 1-4 in preparing hypoglycemic agents.
    Type: Application
    Filed: August 22, 2007
    Publication date: June 2, 2011
    Applicant: Institute of Materia Medica Chinese Academy of Medical Sciences
    Inventors: Yuling Liu, Zhufang Shen, Zhen Chen, Renyun Wang, Xuejun Xia, Yueteng Chen, Quan Liu, Sujuan Sun, Mingzhi Xie
  • Agarofuan derivatives, their preparation, pharmaceutical composition containing them and their use as medicine
    Patent number: 6486201
    Abstract: The compound represented by formula (I), in which the substitutes are defined as in the specification and the claims, or their stereoisomers, the process for preparing them, pharmaceutical composition containing them and their use as medicine.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: November 26, 2002
    Assignee: Institute of Materia Medica, Chinese Academy of Medical Science (CN)
    Inventors: Jiyu Guo, Weijun Wang, Hongju Fang, Qian Liu, Wuyan Zhang, Dali Yin, Sujuan Sun, Ruiwu Liu, Chun Li, Haifan Liu, Donghui Wang