Abstract: The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.

Abstract: The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.

Abstract: The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.

Abstract: A double-resonant coil includes a closed conductor loop divided into at least two segments that are each connected via a second connection element configured to be converted from an electrically conductive state to an electrically insulating state. The double-resonant coil further includes an inductor or a capacitor connected in series to a first connection element so as to allow excitation of the closed conductor loop in a dipole mode at one frequency and with a homogeneous power distribution at a second frequency.

Abstract: The present invention relates HMG-CoA reductase degradation inducing compounds. Specifically, the present invention relates a bifunctional compound in which a HMG-CoA reductase binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention also relates a method for preparing the compounds, and a method for degradation of HMG-CoA reductase using the compounds, as well as use for prevention or treatment of HMG-CoA reductase related diseases using the compounds.

Abstract: The present disclosure provides a method of managing a system and an apparatus therefor. The method of the present disclosure may include providing a menu management tool for managing a menu of a system, setting an item of the menu and an authority to access the item by receiving an input through the menu management tool, and providing, when a terminal having the authority accesses the system, information regarding the item to the terminal.

Abstract: A fuel cell includes a cell stack including a plurality of unit cells stacked in a first direction; a first end plate including a guide through-hole formed therein, the first end plate being disposed on one end of two ends of the cell stack; a second end plate including a guide support hole formed therein, the guide support hole overlapping the guide through-hole in the first direction, the second end plate being disposed on an opposite end of the two ends of the cell stack; and an enclosure surrounding a side portion between the two ends of the cell stack together with the first end plate and the second end plate, the enclosure being formed as a unitary structure. The enclosure includes a body surrounding the side portion of the cell stack and first and second ends coupled to the first end plate and the second end plate, respectively.

Abstract: According to an embodiment of the present disclosure, a semiconductor memory device includes a bit line sense amplifier coupled between a pull-up voltage line and a pull-down voltage line, and suitable for sensing a voltage difference between first and second bit lines by sequentially performing a precharge operation, an offset cancellation operation, a charge sharing operation, and an amplification operation, wherein the bit line sense amplifier pre-biases a voltage level of the second bit line depending on a voltage level of the first bit line during the charge sharing operation; and a driving circuit suitable for supplying operating voltages to the pull-up voltage line and the pull-down voltage line during the offset cancellation operation, the charge sharing operation, and the amplification operation.

Abstract: A system and method of controlling operation of an internal combustion engine are provided. The method includes performing a cylinder deactivation operation while running the engine, selecting at least one of the plurality of temperature maintenance actions to increase an exhaust temperature, and performing at least one of the plurality of temperature maintenance actions effective to increase the exhaust temperature. The plurality of temperature maintenance actions may include one or more of a charge air cooler bypass operation, an EGR cooler bypass operation, an aftertreatment system heater operation, a turbocharger bypass operation, a turbocharger geometry adjustment operation, an intake air throttle adjustment operation, and a delayed injection timing operation, or combinations thereof.

Abstract: A plug connector according to an embodiment includes: a connector main body which includes one pair of first sidewalls extended in a first direction and facing each other, and one pair of second sidewalls extended in a second direction perpendicular to the first direction, and facing each other; one pair of fitting nails which are coupled to the connector main body; and a plurality of plug terminals which are coupled to the one pair of second sidewalls, wherein each of the one pair of fitting nails includes: an upper surface which is in contact with an upper end of the first sidewall; a central reinforcement portion which is curved downward from the upper surface to come into contact with at least a portion of an outer surface of the first sidewall; and one pair of lateral reinforcement portions which are extended from both ends of the upper surface in the second direction to come into contact with an upper end of the second sidewall, wherein the central reinforcement portion includes a central solder portion

Abstract: A plug connector for a board-to-board connector according to an embodiment includes: a connector main body which includes one pair of first sidewalls extended in a first direction and facing each other, and one pair of second sidewalls extended in a second direction perpendicular to the first direction, and facing each other; one pair of fitting nails which are over-molded in the plug connector; and a plurality of plug terminals which are over-molded on the one pair of second sidewalls, wherein each of the one pair of fitting nails includes: an upper surface contacting an upper end of the first sidewall; a central reinforcement portion which is curved downward from the upper surface to come into contact with at least a portion of an outer surface of the first sidewall; one pair of lateral reinforcement portions which are extended from the upper surface and are curved downward to come into contact with at least portions of respective outer surfaces of the one pair of second sidewalls; and one pair of arm porti

Abstract: A fuel cell is provided that includes a cell stack having a plurality of unit cells stacked in a first direction. An enclosure is disposed to surround the cell stack and includes an inlet that suctions external air and an outlet that discharges air that has been suctioned through the inlet and has circulated in the space between the cell stack and the enclosure. An insulating member is disposed to extend in the first direction in the space between an outer surface of the cell stack and an inner surface of the enclosure. The insulating member divides the space into a plurality of spaces and has an aperture formed therein to provide communication between the divided plurality of spaces, and an air intake member configured to suction air discharged from the outlet.

Abstract: A dipole antenna array includes at least two dipole antenna elements. Each respective dipole antenna element has at one end a fold which consists of a bend, a bent region, and the projection of the bent region of the dipole antenna element onto a length of the dipole antenna element. Each respective dipole antenna element at least partially encloses a cavity.

Abstract: Provided is an information providing method of an electronic apparatus, the method including identifying sales information of an item that is for sale through the network, identifying whether it is necessary to provide item sales management information based on the identified sales information of the item, and, when it is necessary to provide the item sales management information, providing the item sales management information generated based on the sales information of the item.

Abstract: Disclosed is a cooking utensil with double folding which includes a body part of which one of cooking utensils such as scoops, forks, spoons, flip, spatulas and cooking spoons is selectively formed from an end, a handle part, and a rotating part which includes at least two or more holes formed in one side and the other side thereof so that one end is connected to the first rack portion and the other end is connected to the second rack portion to be doubly foldable.

Abstract: A fuel cell is disclosed. The fuel cell includes a cell stack including a plurality of unit cells stacked in a first direction, an enclosure surrounding side portions of the cell stack and including at least one opening to expose at least one of opposite end portions of the cell stack therethrough, first and second end plates respectively disposed at the opposite end portions of the cell stack, and a gasket disposed between a target end plate disposed in the at least one opening in the enclosure, among the first and second end plates, and the enclosure in order to seal the cell stack.

Abstract: According to an embodiment of the present disclosure, a semiconductor memory device includes a bit line sense amplifier coupled between a pull-up voltage line and a pull-down voltage line, and suitable for sensing a voltage difference between first and second bit lines by sequentially performing a precharge operation, an offset cancellation operation, a charge sharing operation, and an amplification operation, wherein the bit line sense amplifier pre-biases a voltage level of the second bit line depending on a voltage level of the first bit line during the charge sharing operation; and a driving circuit suitable for supplying operating voltages to the pull-up voltage line and the pull-down voltage line during the offset cancellation operation, the charge sharing operation, and the amplification operation.

Abstract: A computer-implemented system and a method for automatic electronic order creation are disclosed. The system and method may be configured to: receive a digitized document comprising embedded metadata related to contents of the digitized document; analyze the embedded metadata to extract a boundary parameter; generate a unique reference identifier associated with the digitized document and the boundary parameter; receive a first input data setting one or more target measurements for one or more predefined periods of time, wherein a sum of the one or more target measurements is less than or equal to the boundary parameter; receive a second input data setting configuration data for achieving the one or more target measurements; and generate an electronic order based on the configuration data.

Abstract: Provided is a sensorless control device for a DC fuel pump that may be downsized as compared to a conventional control device for a DC fuel pump and may implement the same operation at a relatively low cost, and the sensorless control device for a DC fuel pump.

Abstract: A coil assembly for use as a transmission and/or receiving coil in an MR system comprises a dipole antenna assembly with multiple dipole antennas. Connection elements are converted from an electrically conductive state to an electrically non-conductive state. In the electrically conductive state, the dipole antennas form a cylindrical volume coil and/or a conductor loop assembly, in particular a flat conductor loop assembly. The connection elements comprise blocking circuits which automatically block when a high-frequency alternating voltage with a frequency corresponding to the blocking frequency of the connection element blocking circuits is applied to the coil assembly.