Abstract: The present invention relates to small lipid nanoparticles, a small lipid nanoparticle (SLNP)-based nanovaccine platform including same, and a combination treatment regimen with an immune checkpoint inhibitor. Lipid nanoparticies according to the present invention can easily deliver antigens and anionic drugs into cells, and exhibit strong anti-tumor effects when loaded with tumor-associated antigens. Particularly, a cancer vaccine kit according to the present invention including lipid nanoparticles according to the present invention as a first vaccine composition and lipid nanoparticles and an immune checkpoint inhibitor as a second vaccine composition can be used to effectively suppress tumor regrowth and recurrence triggered by the occurrence of immunosuppression against a cancer nanovaccine.

Abstract: The present invention relates to a pharmaceutical composition comprising a hydroquinone derivative of general formula 1 as an active ingredient. The pharmaceutical composition has the effects of: enabling the prevention or treatment of obesity by inhibiting weight gain and visceral fat accumulation; and enabling the prevention or treatment of nonalcoholic steatohepatitis by inhibiting fat accumulation in liver tissue and lobular inflammation, and by improving insulin resistance.

Abstract: The present invention relates to a method, and a cell for carrying out the method for the electrochemical reduction of dinitrogen to ammonia. The method comprises the steps of: (1) contacting a cathodic working electrode comprising a nanostructured catalyst with an electrolyte comprising (a) one or more liquid salts optionally in combination with (b) one or more organic solvents having low viscosity and supporting high ionic conductivity, and (2) introducing dinitrogen and a source of hydrogen to the electrolyte, wherein the dinitrogen is reduced to ammonia at the cathodic working electrode.

Abstract: The invention relates to a method and an electrochemical cell comprising a cathodic working electrode comprising a nanostructured catalyst, a counter electrode and an electrolyte for the reduction of dinitrogen to ammonia. The invention includes introducing dinitrogen and a source of hydrogen to the electrolyte, wherein the dinitrogen is reduced to ammonia at the cathodic working electrode. The electrolyte comprises one or more liquid salts formed from the combination of a specified set of cations and a specified set of anions.