Abstract: A label-free optical device for near real time quantification of the multifractal micro-optical properties of a sample includes a source of broadband light; a tunable filter that receives at least a portion of the broadband light and then transmits narrowband light, whereby a specific band of light is selected to avoid unwanted absorption of light by the sample; where the narrowband light is configured to illuminate a selected area of the sample, and in response elastically-scattered light is dispersed from the sample; a light collection device configured to collect at least some of the elastically-scattered light; where at least some of the collected elastically-scattered light is configured to be transmitted to a detector by the light collection device, and the detector is configured to record a light scattering signal; and where the detector is configured to perform light scattering signal measurements at multiple angles or wavelengths to determine a refractive index multifractality of the sample.

Abstract: This invention, in one aspect, relates generally to compositions and methods for modulating cellular activities by synthetic opsins. Further, the invention provides method for the use of synthetic opsins for vision restoration and other applications, wherein the amino acid sequence of the synthetic opsin is modified to provide enhanced light sensitivity, kinetics and ion-selectivity.

Abstract: A label-free optical device for near real time quantification of the multifractal micro-optical properties of a sample includes a source of broadband light; a tunable filter that receives at least a portion of the broadband light and then transmits narrowband light, whereby a specific band of light is selected to avoid unwanted absorption of light by the sample; where the narrowband light is configured to illuminate a selected area of the sample, and in response elastically-scattered light is dispersed from the sample; a light collection device configured to collect at least some of the elastically-scattered light; where at least some of the collected elastically-scattered light is configured to be transmitted to a detector by the light collection device, and the detector is configured to record a light scattering signal; and where the detector is configured to perform light scattering signal measurements at multiple angles or wavelengths to determine a refractive index multifractality of the sample.

Abstract: Principles of the present disclosure are directed to novel methods and devices for efficient and targeted delivery of impermeable exogenous materials such as small molecules, proteins, antibodies, and genes into cells, both in vitro as well as in vivo, which is of great importance for drug, vaccine and gene delivery for various therapeutic applications. Specifically, the invention provides device and method for targeted nano-enhanced optical delivery of opsins for vision restoration in patients with retinal photodegeneration by conventional intravitreal/sub-retinal injection of gold nano-rods and opsin plasmids followed by scanned/spatially modulated laser beam matching the pathological areas determined by Fundoscopy, OCT or scanning ophthalmoscope.

Abstract: This invention, in one aspect, relates generally to compositions and methods for modulating cellular activities by synthetic opsins. Further, the invention provides method for the use of synthetic opsins for vision restoration and other applications, wherein the amino acid sequence of the synthetic opsin is modified to provide enhanced light sensitivity, kinetics and ion-selectivity.

Abstract: Principles of the present disclosure are directed to novel methods and devices for efficient and targeted delivery of impermeable exogenous materials such as small molecules, proteins, antibodies, and genes into cells, both in vitro as well as in vivo, which is of great importance for drug, vaccine and gene delivery for various therapeutic applications. Specifically, the invention provides device and method for targeted nano-enhanced optical delivery of opsins for vision restoration in patients with retinal photodegeneration by conventional intravitreal/sub-retinal injection of gold nano-rods and opsin plasmids followed by scanned/spatially modulated laser beam matching the pathological areas determined by Fundoscopy, OCT or scanning ophthalmoscope.