Publication number: 20110172282
Abstract: This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
Type:
Application
Filed:
October 12, 2007
Publication date:
July 14, 2011
Applicant:
XENON PHARMACEUTICALS INC.
Inventors:
Mikhail Chafeev, Sultan Chowdhury, Robert Fraser, Jianmin Fu, Rajender Kamboj, Duanjie Hou, Shifeng Liu, Mehran Seid Bagherzadeh, Serguei Sviridov, Shaoyi Sun, Jianyu Sun, Nagasree Chakka, Tom Hsieh, Vandna Raina
Patent number: 7951805
Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): Formula (I) where x, y, G, J, L, M, V, W, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8, and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Type:
Grant
Filed:
September 20, 2005
Date of Patent:
May 31, 2011
Assignee:
Xenon Pharmaceuticals Inc.
Inventors:
Rajender Kamboj, Zaihui Zhang, Jianmin Fu, Serguei Sviridov, Shaoyi Sun, Mehran Seid Bagherzadeh, Vandna Raina, Duanjie Hou, Sultan Chowdhury, Shifeng Liu, Vishnumurthy Kodumuru, Nagasree Chakka
Patent number: 7919484
Abstract: This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.
Type:
Grant
Filed:
February 8, 2006
Date of Patent:
April 5, 2011
Assignee:
Xenon Pharmaceuticals Inc.
Inventors:
Rajender Kamboj, Michael D. Winther, Robert Fraser, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Shifeng Liu, Vandna Raina, Mehran Seid Bagherzadeh, Serguei Sviridov, Kashinath Sadalapure, Shaoyi Sun, Vishnumurthy Kodumuru, Nagasree Chakka, Zaihui Zhang, Melwyn Abreo, Mikhail A. Kondratenko, Daniel F. Harvey, Cindy J. Hudson, Wenbao Li, Chi Tu, Sengen Sun, Mark W. Holladay, Heinz W. Gschwend
Patent number: 7754711
Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Type:
Grant
Filed:
February 9, 2005
Date of Patent:
July 13, 2010
Assignee:
Xenon Pharmaceuticals Inc.
Inventors:
Nagasree Chakka, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Michael D. Winther, Zaihui Zhang, Melwyn Abreo, Mark W. Holladay, Wenbao Li, Sengen Sun, Chi Tu, Heinz W. Gschwend
Publication number: 20100173967
Abstract: This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
Type:
Application
Filed:
October 12, 2007
Publication date:
July 8, 2010
Applicant:
XENON PHARMACEUTICALS INC.
Inventors:
Mikhail Chafeev, Sultan Chowdhury, Robert Fraser, Jianmin Fu, Rajender Kamboj, Duanjie Hou, Shifeng Liu, Mehran Seid Bagherzadeh, Serguei Sviridov, Shaoyi Sun, Jianyu Sun, Nagasree Chakka, Tom Hsieh, Vandna Raina
Publication number: 20100130487
Abstract: This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
Type:
Application
Filed:
December 30, 2009
Publication date:
May 27, 2010
Applicant:
XENON PHARMACEUTICALS INC.
Inventors:
Mikhail Chafeev, Nagasree Chakka, Sultan Chowdhury, Robert Fraser, Jianmin Fu, Duanjie Hou, Tom Hsieh, Rajender Kamboj, Shifeng Liu, Vandna Raina, Mehran Seid Bagherzadeh, Jianyu Sun, Shaoyi Sun, Serguei Sviridov
Publication number: 20100125072
Abstract: This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
Type:
Application
Filed:
December 30, 2009
Publication date:
May 20, 2010
Applicant:
XENON PHARMACEUTICALS INC.
Inventors:
Mikhail Chafeev, Nagasree Chakka, Sultan Chowdhury, Robert Fraser, Jianmin Fu, Duanjie Hou, Tom Hsieh, Rajender Kamboj, Shifeng Liu, Vandna Raina, Mehran Seid Bagherzadeh, Jianyu Sun, Shaoyi Sun, Serguei Sviridov
