Patents by Inventor Sum Chan

Sum Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12650436
    Abstract: A method for determining a combined amount of ?-tocopherol and ?-tocopherol in a sample by tandem mass spectrometry includes subjecting the sample to ionization under conditions suitable to produce one or more ions from the ?-tocopherol and ?-tocopherol detectable by mass spectrometry; and determining the amount of one or more of the ions by tandem mass spectrometry. Tandem mass spectrometry methods of this disclosure involve fragmenting ?-tocopherol and ?-tocopherol ions having a mass to charge ratio of about 416.35±0.80 into one or more fragment ions including a fragment ion having a mass to charge ratio of about 151.00±0.80, wherein the amount of the one or more ions determined is related to the combined amount of ?-tocopherol and ?-tocopherol in the sample.
    Type: Grant
    Filed: January 8, 2026
    Date of Patent: June 9, 2026
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Sum Chan, Qibo Jiang
  • Publication number: 20260140125
    Abstract: A method for determining a combined amount of ?-tocopherol and ?-tocopherol in a sample by tandem mass spectrometry includes subjecting the sample to ionization under conditions suitable to produce one or more ions from the ?-tocopherol and ?-tocopherol detectable by mass spectrometry; and determining the amount of one or more of said ions by tandem mass spectrometry, wherein tandem mass spectrometry comprises fragmenting ?-tocopherol and ?-tocopherol ions having a mass to charge ratio of about 416.35±0.80 into one or more fragment ions comprising a fragment ion having a mass to charge ratio of about 151.00±0.80, wherein the amount of the one or more ions determined is related to the combined amount of ?-tocopherol and ?-tocopherol in the sample.
    Type: Application
    Filed: January 8, 2026
    Publication date: May 21, 2026
    Inventors: Sum Chan, Qibo Jiang
  • Publication number: 20260133209
    Abstract: A method for determining a combined amount of ?-tocopherol and ?-tocopherol in a sample by tandem mass spectrometry includes subjecting the sample to ionization under conditions suitable to produce one or more ions from the ?-tocopherol and ?-tocopherol detectable by mass spectrometry; and determining the amount of one or more of said ions by tandem mass spectrometry, wherein tandem mass spectrometry comprises fragmenting ?-tocopherol and ?-tocopherol ions having a mass to charge ratio of about 416.35±0.80 into one or more fragment ions comprising a fragment ion having a mass to charge ratio of about 151.00±0.80, wherein the amount of the one or more ions determined is related to the combined amount of ?-tocopherol and ?-tocopherol in the sample.
    Type: Application
    Filed: January 8, 2026
    Publication date: May 14, 2026
    Inventors: Sum Chan, Qibo Jiang
  • Publication number: 20250102491
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Application
    Filed: December 10, 2024
    Publication date: March 27, 2025
    Inventors: Changming Yang, Sum Chan
  • Publication number: 20250067758
    Abstract: A method for determining a combined amount of ?-tocopherol and ?-tocopherol in a sample by tandem mass spectrometry includes subjecting the sample to ionization under conditions suitable to produce one or more ions from the ?-tocopherol and ?-tocopherol detectable by mass spectrometry; and determining the amount of one or more of said ions by tandem mass spectrometry, wherein tandem mass spectrometry comprises fragmenting ?-tocopherol and ?-tocopherol ions having a mass to charge ratio of about 416.35±0.80 into one or more fragment ions comprising a fragment ion having a mass to charge ratio of about 151.00±0.80, wherein the amount of the one or more ions determined is related to the combined amount of ?-tocopherol and ?-tocopherol in the sample.
    Type: Application
    Filed: November 7, 2024
    Publication date: February 27, 2025
    Inventors: Sum Chan, Qibo Jiang
  • Publication number: 20250054742
    Abstract: Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5?-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.
    Type: Application
    Filed: October 25, 2024
    Publication date: February 13, 2025
    Inventors: Qibo Jiang, Sum Chan, Richard E. Reitz
  • Patent number: 12196742
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Grant
    Filed: October 16, 2023
    Date of Patent: January 14, 2025
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Changming Yang, Sum Chan
  • Publication number: 20250002971
    Abstract: Provided are methods for determining the amount of total thiamine in a body fluid sample using liquid chromatography and mass spectrometry. Total thiamine is converted to free thiamine by treatment with an acid phosphatase prior to thiamine separation and quantification.
    Type: Application
    Filed: September 13, 2024
    Publication date: January 2, 2025
    Inventors: Sum Chan, Qibo Jiang, Richard E Reitz
  • Patent number: 12174203
    Abstract: Methods are described for measuring the amount of one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample.
    Type: Grant
    Filed: November 28, 2022
    Date of Patent: December 24, 2024
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Sum Chan, Qibo Jiang
  • Patent number: 12165861
    Abstract: Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5?-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.
    Type: Grant
    Filed: September 13, 2023
    Date of Patent: December 10, 2024
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Qibo Jiang, Sum Chan, Richard E Reitz
  • Patent number: 12116617
    Abstract: Provided are methods for determining the amount of total thiamine in a body fluid sample using liquid chromatography and mass spectrometry. Total thiamine is converted to free thiamine by treatment with an acid phosphatase prior to thiamine separation and quantification.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: October 15, 2024
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Sum Chan, Qibo Jiang, Richard E. Reitz
  • Publication number: 20240044864
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Application
    Filed: October 16, 2023
    Publication date: February 8, 2024
    Inventors: Changming Yang, Sum Chan
  • Publication number: 20230420235
    Abstract: Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5?-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.
    Type: Application
    Filed: September 13, 2023
    Publication date: December 28, 2023
    Inventors: Qibo Jiang, Sum Chan, Richard E Reitz
  • Patent number: 11821889
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: November 21, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Changming Yang, Sum Chan
  • Patent number: 11798794
    Abstract: Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5?-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: October 24, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Qibo Jiang, Sum Chan, Richard E. Reitz
  • Publication number: 20230096666
    Abstract: Methods are described for measuring the amount of one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample.
    Type: Application
    Filed: November 28, 2022
    Publication date: March 30, 2023
    Inventors: Sum CHAN, Qibo JIANG
  • Patent number: 11513130
    Abstract: Methods are described for measuring the amount of one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: November 29, 2022
    Assignee: Quest Diagnostics Investment Incoporated
    Inventors: Sum Chan, Qibo Jiang
  • Publication number: 20220229041
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Application
    Filed: April 7, 2022
    Publication date: July 21, 2022
    Inventors: Changming Yang, Sum Chan
  • Patent number: 11300559
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: April 12, 2022
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Changming Yang, Sum Chan
  • Publication number: 20210239718
    Abstract: Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.
    Type: Application
    Filed: April 19, 2021
    Publication date: August 5, 2021
    Inventors: Qibo Jiang, Richard E. Reitz, Sum Chan