Patents by Inventor Suma Sreenivas

Suma Sreenivas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleotide sequence and a process thereof
    Patent number: 9862958
    Abstract: The present disclosure relates to a process of identification and isolation of sorbitol dehydrogenase promoter from Pichia pastoris. Further, the present disclosure also relates to expression of heterologous proteins under the control of Sorbitol dehydrogenase promoter in Pichia pastoris.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: January 9, 2018
    Assignee: Biocon Limited
    Inventors: Nagaraj Govindappa, Sankar Periyasamy, Shivakumar Madenahalli Channabasappa, Suma Sreenivas, Kedamath Nanjund Sastry
  • Process of expressing a fully folded functional two chain insulin glargine
    Patent number: 9388227
    Abstract: The disclosure relates to a process of obtaining a fully folded two chain insulin glargine that require no further processing to make it functionally active. The present disclosure discloses a surprising effect of over expression of Kex2p intracellularly under the control of inducible FLD1 promoter in the host Pichia pastoris to produce two chain functional glargine secreted directly in the medium. The schematic diagram of how the two chains are made inside the host Pichia pastoris and secretes into the medium.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: July 12, 2016
    Assignee: Biocon Limited
    Inventors: Nagaraj Govindappa, Suma Sreenivas, Komal N. Kanojia, Yogesh Basavaraju, Kedamath Nanjund Sastry
  • SIGNAL SEQUENCE FOR PROTEIN EXPRESSION IN PICHIA PASTORIS
    Publication number: 20160168198
    Abstract: The present invention relates to a signal sequence from a unique Pichia pastoris protein. Further the invention discloses use of signal sequence for the expression of heterologous protein in Pichia pastoris.
    Type: Application
    Filed: June 27, 2014
    Publication date: June 16, 2016
    Inventors: Nagaraj Govindappa, Suma Sreenivas, Sankar Periyasamy, Srividya Divakar
  • NUCLEOTIDE SEQUENCE AND A PROCESS THEREOF
    Publication number: 20150284731
    Abstract: The present disclosure relates to a process of identification and isolation of sorbitol dehydrogenase promoter from Pichia pastoris. Further, the present disclosure also relates to expression of heterologous proteins under the control of Sorbitol dehydrogenase promoter in Pichia pastoris.
    Type: Application
    Filed: December 5, 2012
    Publication date: October 8, 2015
    Inventors: Nagaraj Govindappa, Sankar Periyasamy, Shivakumar Madenahalli Channabasappa, Suma Sreenivas, Kedamath Nanjund Sastry
  • Process for preparation of insulin compounds
    Patent number: 9090705
    Abstract: The present invention relates to the preparation of insulin compounds including their analogs or derivatives thereof from their corresponding precursor forms by a one step enzymatic reaction involving the combinatorial and concurrent use of optimal quantities of trypsin and carboxypeptidase B that work synergistically directing the reaction in a controlled manner to avoid production of random undesired byproducts. Particularly, the enzymatic conversion reactions of the instant invention offer advantages of reduction in the number operational steps, higher yield and purity of the desired end products.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: July 28, 2015
    Assignee: Biocon Limited
    Inventors: Partha Hazra, Srikanth Gollarahosahalli Sathyanarayana, Suma Sreenivas, Manjunath Hadavanahalli Shivarudraiah, Kedarnath Nanjund Sastry, Harish Iyer
  • SECRETION OF FUNCTIONAL INSULIN GLARGINE DIRECTLY INTO THE CULTURE MEDIUM THROUGH OVER EXPRESSION OF KEX2P INTRACELLULARLY
    Publication number: 20150118710
    Abstract: The disclosure relates to a process of obtaining a fully folded two chain insulin glargine that require no further processing to make it functionally active. The present disclosure discloses a surprising effect of over expression of Kex2p intracellularly under the control of inducible FLD1 promoter in the host Pichia pastoris to produce two chain functional glargine secreted directly in the medium. The schematic diagram of how the two chains are made inside the host Pichia pastoris and secretes into the medium.
    Type: Application
    Filed: June 6, 2012
    Publication date: April 30, 2015
    Applicant: Biocon Limited
    Inventors: Nagaraj Govindappa, Suma Sreenivas, Komal N. Kanojia, Yogesh Basavaraju, Kedarnath Nanjund Sastry
  • Process for Preparation of Insulin Compounds
    Publication number: 20110159538
    Abstract: The present invention relates to the preparation of insulin compounds including their analogs or derivatives thereof from their corresponding precursor forms by a one step enzymatic reaction involving the combinatorial and concurrent use of optimal quantities of trypsin and carboxypeptidase B that work synergistically directing the reaction in a controlled manner to avoid production of random undesired byproducts. Particularly, the enzymatic conversion reactions of the instant invention offer advantages of reduction in the number operational steps, higher yield and purity of the desired end products.
    Type: Application
    Filed: September 19, 2008
    Publication date: June 30, 2011
    Applicant: BIOCON LIMITED
    Inventors: Partha Hazra, Srikanth Gollarahosahalli Sathyanarayana, Suma Sreenivas, Manjunath Hadavanahalli Shivarudraiah, Kedarnath Nanjund Sastry, Harish Iyer