Patents by Inventor Suman Dhawan

Suman Dhawan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for blocking endothelial cell-leukocyte attachment by inhibiting expression of adhesion molecules on the vascular endothelium for therapeutic applications
    Patent number: 6395772
    Abstract: A method for blocking the attachment of leukocytes to endothelial cells/lining of the blood vessels using a plant derived protoberberine alkaloid, berberine or its pharmaceutically acceptable salts. This prevents tissue damage to the surrounding tissue. The method also can be used to prevent and/or treat clinical manifestations that involve endothelial cell-leukocyte attachment, for example septic shock, arthritis, psoriasis, multiple sclerosis, allergic asthma, metastatic melanoma and graft rejection.
    Type: Grant
    Filed: May 3, 1999
    Date of Patent: May 28, 2002
    Assignee: National Institute of Immunology
    Inventors: Shakti N. Upadhyay, Suman Dhawan
  • Methods for prevention and treatment of septic shock
    Patent number: 6291483
    Abstract: Berberine or pharmaceutically acceptable salts thereof either alone or in combination with cyclosporin can be used to treat or prevent graft vs. host disease. Berberine or pharmaceutically acceptable salts thereof can also be used to treat or prevent septic shock syndrome.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: September 18, 2001
    Assignee: National Institute of Immunology
    Inventors: Shakti N. Upadhyay, Suman Dhawan
  • Method for suppressing allogenic immune response or prevention/treatment of graft vs. host disease or graft rejection
    Patent number: 6245781
    Abstract: Berberine or pharmaceutically acceptable salts thereof either alone or in combination with cyclosporin can be used to treat or prevent graft vs. host disease. Berberine or pharmaceutically acceptable salts thereof can also be used to treat or prevent septic shock syndrome.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: June 12, 2001
    Assignee: National Institute of Immunology
    Inventors: Shakti N. Upadhyay, D. N. K. Sarma, Nalini Wali, N. K. Saraswathi, Suman Dhawan
  • Neem oil as a male contraceptive
    Patent number: 5501855
    Abstract: An alternate approach to vasectomy for long term male contraception following a single intra-vas.application of a traditional plant (Azadirachta indica) product having immunomodulatory properties is described. The intra-vas administration of neem oil to male rats resulted in a block of spermatogenesis without affecting the testosterone production; the seminiferous tubules, although reduced in diameter, appeared normal and contained mostly early spermatogenic cells. No antisperm antibody could be detected in the serum. Unilateral administration of neem oil in the vas resulted in a significant reduction of testicular size and spermatogenic block only on the side of application; the draining lymph node cells of the treated side also showed enhanced proliferative response to in vitro mitogen challenge. These results indicate that intra-vas application of neem oil is effective in blocking fertility in male mammals after a single injection.
    Type: Grant
    Filed: September 2, 1993
    Date of Patent: March 26, 1996
    Inventors: Gursaran P. Talwar, Shakti N. Upadhyay, Suman Dhawan