Abstract: A Virtual Patient Care (VPC) platform establishes a video call between a patient application and a clinician application. During the video call Selfie Vitals are measured using the selfie camera on the patient's smartphone. The patient's video is paused to the clinician and sent to Artificial Intelligence (AI) engines using remote Photoplethysmography (rPPG) or Transdermal Optical Imaging (TOI) techniques to extract vital signs. Pulse, blood pressure, oxygen saturation, and respiration rate vital signs are generated and displayed on the clinician' s user interface. Audio continues while video conferencing may be paused during vitals measurement. The patient's smartphone can perform pre-processing to generate metadata that is sent to a VPC server with more powerful AI engines. Vitals measurement can be initiated by the patient selecting a Selfie Vitals icon on a patient user interface during the video conference call or can be initiated by the clinician.