Abstract: A system or platform with architecture for dynamically orchestrating secure data flows across components in a healthcare enterprise, including, but not limited to, medical devices, electronic health records, clinical decision support systems, patient administration systems, and the like. The present invention enables plug-and-play interoperability via standards-based, trusted, bi-directional communication between components. The system provides dynamic registration of components and their profiles, runtime provisioning of communications channels, and dynamic orchestration of data between components. Component profiles abstract devices and applications as services producing and consuming certain messages that represent portions of a canonical data model. Registration takes a component identity and assigns an identifier and address to broker communication with the component.