Patents by Inventor Sumeda Jayasena

Sumeda Jayasena has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systematic evolution of ligands by exponential enrichment: blended SELEX
    Patent number: 7176295
    Abstract: A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO:1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is a single-stranded DNA ligand to elastase coupled to N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone (SEQ ID NO:2). This elastase blended nucleic acid ligand inhibits the biological activity of elastase.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: February 13, 2007
    Assignee: Gilead Sciences, Inc.
    Inventors: Gregory Biesecker, Sumeda Jayasena, Larry Gold, Drew Smith, Gary P. Kirschenheuter