Abstract: A hemostasis valve for use in a medical device. The hemostasis valve may include a generally cylindrical body having a proximal side, a distal side, and a thickness extending therebetween. The proximal side may include a tapered central region having a surface sloped towards a center of the body and the distal side may include a distally extending curved central region.

Abstract: A tightening port for use with a hemostasis valve of an introducer sheath includes a gripper configured for engagement with the hemostasis valve hub, the gripper having a proximal end, a distal end, a cylindrical body defining a lumen, and a plurality of protrusions extending from the proximal end, a base having a cylindrical body and a lumen defined therethrough for receiving a portion of the gripper, and a plurality of engagement features configured for engaging with the plurality of protrusions of the gripper, and wherein the lumen of the gripper has an initial diameter prior to engagement with the base, and the lumen of the gripper has a compressed diameter after engagement with the base, wherein the compressed diameter is less than the initial diameter.

Abstract: A tightening port for use with a hub of an introducer sheath includes a cartridge for reversible engagement with a proximal end of the hub, the cartridge having a proximal end and a distal end and a lumen extending therebetween, a seal positioned within the lumen of the cartridge, a lock nut having an inner portion positioned within the lumen of the cartridge and an outer portion configured for engagement with the proximal end of the cartridge, such that the inner portion of the lock nut is configured to push the seal to reduce a size of an opening of the seal.

Abstract: A hemostasis valve hub for a sheath, such as an introducer sheath, includes a hub base including a first arm defining a first lumen and having a distal end and a proximal end and a second arm extending from the first arm and defining a second lumen and having a distal end and a proximal end, a seal positioned within the first lumen and adjacent a lock nut, the lock nut engaged with the proximal end of the first arm and positioned at least partially within the first lumen, a primary seal positioned adjacent the proximal end of the first arm, and a secondary seal positioned adjacent the proximal end of the second arm.

Abstract: A hemostasis valve hub for an introducer sheath includes a hub base, a hub cap configured for engagement with the hub base, the hub cap having a first wall with a first opening and a second opening extending through the first wall, a manifold positioned within the hub cap and adjacent the hub base, a primary seal positioned adjacent the first opening of the hub cap, a secondary seal positioned adjacent the second opening of the hub cap, and wherein the primary seal and the secondary seal are configured to provide a fluid seal between the first opening and the second opening, respectively, and the hub base.

Abstract: A hemostasis valve hub for use with an introducer sheath includes a base having a securing mechanism for securing the hemostasis valve hub to the introducer sheath, an outer shell securable to the base and defining an interior volume, a shutter helix section disposed within the interior volume and including a plurality of fins arranged in a helical fashion, a brush section disposed within the interior volume adjacent the disk shutter section, the brush section including a plurality of brushes arranged in a helical fashion, and a seal positioned within the base and adjacent the brush section, the seal having a partial cross slit arrangement.

Abstract: A hemostasis valve assembly for use in a medical device. The hemostasis valve assembly may include a main body portion defining an internal cavity, a seal cartridge disposed within the internal cavity, and a low pressure valve assembly positioned within the internal cavity adjacent to the seal cartridge. The low pressure valve assembly may include a first valve member having a first valve body and a second valve member having second valve body. A portion of a distal side of the first valve member may abut at least a portion of a proximal side of the second valve member.

Abstract: A hemostasis valve assembly for use in a medical device. The hemostasis valve assembly may include a main body portion defining an internal cavity, a seal cartridge disposed within the internal cavity, and a low pressure valve assembly positioned within the internal cavity adjacent to the seal cartridge. The low pressure valve assembly may include a first valve member having a first valve body and a second valve member having second valve body. A portion of a distal side of the first valve member may abut at least a portion of a proximal side of the second valve member.

Abstract: The present disclosure provides photoacoustic-imaging techniques using an optically-transparent bulk piezoelectric ultrasound transducer. A PAI system is disclosed. The PAI system has an optically translucent piezoelectric substrate, and a light source capable of providing light through the transducer to a region of interest.

Abstract: Hemostasis valves and methods for making and using hemostasis valves are disclosed. An example hemostasis valve may include a main body having a proximal end region. A cartridge may be at least partially disposed within the proximal end region. The cartridge including a seal member. The cartridge may have a proximal member, a distal member, and may define a seal holding region. The seal member may have an axial thickness of about 0.04 to about 0.2 inches. The seal member may be secured within the seal holding region by a mechanical bond.

Abstract: Hemostasis valves and methods for making and using hemostasis valves are disclosed. An example method for assembling a hemostasis valve may include positioning a plunger along a threaded proximal end region of a main body. The threaded proximal end region may include one or more threads and an axial slot extending through the one or more threads. The method may also include advancing the plunger along the threaded proximal end region to a position where a proximal end of the plunger is disposed distally of at least a portion of the one or more threads and disposing a nut adjacent to the threaded proximal end region. The method may also include aligning an alignment tab of the nut with the axial slot, engaging the nut with the one or more threads while the alignment tab is aligned with the axial slot, and rotating the nut 45-270°.

Abstract: A hemostasis valve for use in a medical device. The hemostasis valve may include a generally cylindrical body having a proximal side, a distal side, and a thickness extending therebetween. The proximal side may include a tapered central region having a surface sloped towards a center of the body and the distal side may include a distally extending curved central region.

Abstract: Hemostasis valves and methods for making and using hemostasis valves are disclosed. An example hemostasis valve may include a main body having a distal end region and a proximal end region. A first seal member may be disposed within the proximal end region of the main body. A cartridge may be at least partially disposed within the proximal end region of the main body. The cartridge may include a second seal member. The cartridge may have one or more projections formed thereon. The proximal end region of the main body may have one or more recesses formed therein. The one or more recesses may be designed to engage the one or more projections. A plunger may be coupled to the proximal end region of the main body.

Abstract: A hemostasis valve for use in a medical device. The hemostasis valve may include a generally cylindrical body having a proximal side, a distal side, and a thickness extending therebetween. The proximal side may include a tapered central region having a surface sloped towards a center of the body and the distal side may include a distally extending curved central region.

Abstract: Hemostasis valves and methods for making and using hemostasis valves are disclosed. An example hemostasis valve may include a main body having a distal end region and a proximal end region. A first seal member may be disposed within the proximal end region of the main body. A cartridge may be at least partially disposed within the proximal end region of the main body. The cartridge may include a second seal member. A plunger may be coupled to the proximal end region of the main body. A rotation limiting member may be positioned adjacent to the proximal end region of the main body. A tab member may be positioned adjacent to the proximal end region of the main body. The tab member may be designed to rotate relative to the proximal end region of the main body until the tab member engages the rotation limiting member.

Abstract: An access sheath assembly can include an elongate sheath for accessing an interior of an artery or vein through an access point on a patient's limb and a hub that is coupled to the elongate sheath and that includes an access port configured to provide access to an interior of the elongate sheath. The assembly includes a closure device configured to fit about the patient's limb and capable of being coupled with the hub, the closure device movable between an engaged configuration in which the closure device is coupled with the hub and thus is positioned to secure the hub relative to the patient's limb and a disengaged configuration in which the closure device is apart from the hub and extends about the patient's limb at the access point in order to provide pressure to the access point.

Abstract: Hemostasis valves and methods for making and using hemostasis valves are disclosed. An example hemostasis valve may include a main body having a proximal end region. A cartridge may be at least partially disposed within the proximal end region. The cartridge may include a seal member. The seal member may be designed to shift between an open configuration and a sealed configuration. A plunger, having an inner tubular region and a distal end, may be coupled to the proximal end region of the main body. The distal end of the inner tubular region may be spaced a clearance distance from a proximal end of the seal member so that when the seal member is in the sealed configuration and exposed to pressures of 80-250 pounds per square inch, the seal member deflects into contact with the distal end of the inner tubular region and remains in the sealed configuration.

Abstract: A medical device system may include a valve replacement implant including an anchor member reversibly actuatable between a delivery configuration and a deployed configuration, wherein the implant includes at least one locking element configured to lock the anchor member in the deployed configuration, and at least one actuator element configured to engage the at least one locking element and actuate the anchor member between the delivery configuration and the deployed configuration. The at least one actuator element may include a self-biased cam mechanism configured to extend into and engage a first locking portion of the at least one locking element.

Abstract: Hemostasis valves and methods for making and using hemostasis valves are disclosed. An example hemostasis valve may include a main body having a proximal end region. A cartridge may be at least partially disposed within the proximal end region. The cartridge including a seal member. The cartridge may have a proximal member, a distal member, and may define a seal holding region. The seal member may have an axial thickness of about 0.04 to about 0.2 inches. The seal member may be secured within the seal holding region by a mechanical bond.

Abstract: Hemostasis valves and methods for making and using hemostasis valves are disclosed. An example hemostasis valve may include a main body having a distal end region and a proximal end region. A first seal member may be disposed within the proximal end region of the main body. A cartridge may be at least partially disposed within the proximal end region of the main body. The cartridge may include a second seal member. The cartridge may have one or more projections formed thereon. The proximal end region of the main body may have one or more recesses formed therein. The one or more recesses may be designed to engage the one or more projections. A plunger may be coupled to the proximal end region of the main body.