Patents by Inventor Sumit Chanda

Sumit Chanda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9238815
    Abstract: This application relates to the modulation of host cell factors required for influenza virus replication. The application relates to compounds, including nucleic acid compounds (such as, e.g., small interfering RNAs (siRNAs)) and small molecules, that target human host cell factors involved in influenza virus replication, and the use of such compounds for modulating influenza virus replication and as antiviral agents. The application also relates to methods of treating an influenza virus infection and methods of treating or preventing a symptom or disease associated with influenza virus infection, comprising administering to a subject a composition comprising a compound, such as a nucleic acid compound (e.g., an siRNA) or small molecule, that targets a human host cell factor involved in influenza virus replication.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: January 19, 2016
    Assignees: Icahn School of Medicine at Mounta Sinai, Salk Institute for Biological Studies, Sanford-Burnham Medical Research Institute
    Inventors: Megan Shaw, Peter Palese, Adolfo Garcia-Sastre, Silke Stertz, John Young, Renate König, Sumit Chanda
  • Publication number: 20130090367
    Abstract: This application relates to the modulation of host cell factors required for influenza virus replication. The application relates to compounds, including nucleic acid compounds (such as, e.g., small interfering RNAs (siRNAs)) and small molecules, that target human host cell factors involved in influenza virus replication, and the use of such compounds for modulating influenza virus replication and as antiviral agents. The application also relates to methods of treating an influenza virus infection and methods of treating or preventing a symptom or disease associated with influenza virus infection, comprising administering to a subject a composition comprising a compound, such as a nucleic acid compound (e.g., an siRNA) or small molecule, that targets a human host cell factor involved in influenza virus replication.
    Type: Application
    Filed: December 10, 2010
    Publication date: April 11, 2013
    Inventors: Megan Shaw, Peter Palese, Adolfo Garcia-Sastre, Silke Stertz, John Young, Renate König, Sumit Chanda
  • Publication number: 20090156523
    Abstract: The invention provides methods for modulating insulin signaling pathway and methods for treating insulin resistance. The methods employ agents which modulate FOXO1 subcellular localization. The invention also provides methods of screening for compounds that modulate insulin signaling related activities such as gluconeogenesis and cell proliferation.
    Type: Application
    Filed: July 11, 2006
    Publication date: June 18, 2009
    Applicant: IRM LLC
    Inventors: Charles Cho, Sumit Chanda, Peter G. Schultz
  • Patent number: 7344833
    Abstract: This invention provides novel AP-1 modulatory polypeptides. The invention also provides methods for screening modulators of AP-1 transcription factor activities. The methods comprise first screening test agents for modulators of an AP-1-modulatory polypeptide and then further screening the identified modulating agents for modulators of AP-1 transcription factor activities. The invention further provides methods and pharmaceutical compositions for modulating AP-1 transcription factor activities in a cell and for treating diseases and conditions mediated by abnormal cellular proliferation.
    Type: Grant
    Filed: November 5, 2003
    Date of Patent: March 18, 2008
    Assignee: IRM LLC
    Inventors: Sumit Chanda, Suhaila White, John B. Hogenesch, Jeremy S. Caldwell
  • Publication number: 20070226813
    Abstract: This invention provides cellular regulators of antitumor agent apratoxin A. The invention also provides methods for identifying novel antitumor compounds using these cellular regulators of apratoxin A. The methods comprise first screening test agents for modulators of a cellular regulator of apratoxin A and then further screening the identified modulating agents for antitumor activities. The invention further provides methods and pharmaceutical compositions for treating tumors in a subject.
    Type: Application
    Filed: January 30, 2007
    Publication date: September 27, 2007
    Applicants: IRM LLC, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Hendrik Luesch, Sumit Chanda
  • Publication number: 20050123904
    Abstract: This invention provides novel polypeptides that modulate activities of the replication and transcription activator (RTA) of Kaposi's sarcoma-associated herpesvirus (KSHV). The invention also provides methods for screening modulators of RTA activities. The methods comprise first screening test agents for modulators of an RTA-modulatory polypeptide and then further screening the identified modulating agents for modulators of RTA activities. The invention further provides methods and pharmaceutical compositions for treating diseases and conditions associated with infections of gammaherpesviruses.
    Type: Application
    Filed: August 17, 2004
    Publication date: June 9, 2005
    Applicant: IRM LLC
    Inventors: Josephine Harada, Christian Nelson, Sumit Chanda
  • Publication number: 20050048585
    Abstract: This invention provides novel NF-AT-modulatory polypeptides. The invention also provides methods for screening modulators of NF-AT. The methods comprise first screening test agents for modulators of an NF-AT-modulatory polypeptide and then further screening the identified modulating agents for modulators of NF-AT. The invention further provides methods and pharmaceutical compositions for modulating NF-AT bioactivities in a cell and for treating diseases and conditions mediated by abnormal NF-AT activities.
    Type: Application
    Filed: December 10, 2003
    Publication date: March 3, 2005
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Suhaila White, Sumit Chanda, Jeremy Caldwell
  • Publication number: 20050037390
    Abstract: This invention provides novel Epo-modulating polypeptides. The invention also provides methods for screening modulators of Epo expression. The methods comprise first screening test agents for modulators of an Epo-modulating polypeptide and then further screening the identified modulating agents for modulators of Epo expression. The invention further provides methods and pharmaceutical compositions for modulating Epo expression in cells and for treating diseases and conditions due to Epo deficiency.
    Type: Application
    Filed: June 4, 2004
    Publication date: February 17, 2005
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Fred King, Sumit Chanda, Jeremy Caldwell, John Hogenesch
  • Publication number: 20040171035
    Abstract: This invention provides novel p53 modulatory polypeptides. The invention also provides methods for screening modulators of p53. The methods comprise first screening test agents for modulators of a p53-modulatory polypeptide and then further screening the identified modulating agents for modulators of p53. The invention further provides methods and pharmaceutical compositions for modulating p53 bioactivities in a cell and for treating diseases and conditions mediated by abnormal cellular proliferation.
    Type: Application
    Filed: November 7, 2003
    Publication date: September 2, 2004
    Applicants: IRM LLC, The Scripps Research Institute
    Inventors: Qihong Huang, Sumit Chanda, John B. Hogenesch, Jeremy S. Caldwell
  • Publication number: 20040146903
    Abstract: This invention provides novel AP-1 modulatory polypeptides. The invention also provides methods for screening modulators of AP-1 transcription factor activities. The methods comprise first screening test agents for modulators of an AP-1-modulatory polypeptide and then further screening the identified modulating agents for modulators of AP-1 transcription factor activities. The invention further provides methods and pharmaceutical compositions for modulating AP-1 transcription factor activities in a cell and for treating diseases and conditions mediated by abnormal cellular proliferation.
    Type: Application
    Filed: November 5, 2003
    Publication date: July 29, 2004
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Sumit Chanda, Suhaila White, John B. Hogenesch, Jeremy S. Caldwell