Abstract: The present invention relates generally to methods, algorithms, kits and systems for assessing health, diagnosing disease and generating recommendations using SNV markers specific to a cohort. A genetic sample of an individual is assayed using a genotyping assay to identify at least one SNV. The genotyping assay may be a computer analysis using a database, a nucleic acid microarray assay or a PCR assay. The identified SNV can be compared with a database of SNV markers to identify a plurality of risk SNVs, which are associated with a disease state or pathological condition, including pharmacological sensitivity or resistance. A genetic risk factor (GRF) may be calculated using a weighted score. The GRF is used to determine the risk level associated with the disease. A matrix may be generated using the genetic profile and recommendations specific to cohort and physiologic data. The user is allowed to input physiologic and genomic data, which is compared to the matrix to generate recommendations.