Abstract: A visualization system for use during an ophthalmic procedure. The system includes at least one illumination source configured to emit in a visible and an invisible light spectrum, a light filter configured to allow light within a filtered light spectrum, and an image sensor assembly configured to detect first and second sets of images from the visible and invisible light spectrums, respectively. The system also includes an electronic control unit (ECU) in communication with the at least one illumination source and the image sensor assembly. The ECU is programmed to activate the at least one illumination source to emit light in the visible and the invisible light spectrum and receive image data from the image sensor assembly representative of the first and second sets of images. The controller is also programmed to generate and display at least one composite image based on the first and second sets of images.

Abstract: Ophthalmic viewing systems for visualizing structures on and in an eye of a medical patient include an ophthalmic microscope, a gonioscopy device configured to work with the ophthalmic microscope to provide an image of an interior of the patient's eye, and a robotic arm configured to hold the gonioscopy device in a position in relation to the ophthalmic microscope and the patient's eye to provide the image of the eye's interior.

Abstract: A system includes an actuator, one or more items of diagnostic equipment configured to perform ophthalmic measurement, and one or more items of treatment equipment configured to facilitate performance of an ophthalmic treatment with respect to an eye of a patient. A controller is coupled to the actuator and is configured to cause the actuator to transfer the one or more items of diagnostic equipment and the one or more items of treatment equipment into and out of a region in front of an eye of the patient. The ophthalmic treatment may be a LASIK or SMILE treatment using refractive error and/or eye geometry measured using the diagnostic equipment.

Abstract: A system and method for assisting a surgeon performing an ophthalmic procedure on an eye of a patient, the system including a lubrication assembly. The lubrication assembly may be disposed on a proximal end of a robotic arm, a proximal end of a surgical microscope, or a proximal end of a mobile stand or frame. Dispersal of lubricant from the lubrication assembly may be upon receipt of a direct input from a surgeon, according to a predetermined schedule, or according to an image processing protocol. The lubrication assembly may be moved into position over the eye of the patient manually by the surgeon or through the indirect command of a motion controller which is operable to move the robotic arm or the surgical microscope so as to extend the lubrication assembly into a desired position.

Abstract: The present disclosure provides ophthalmic viewing systems for visualizing structures on and in an eye of a medical patient. Certain embodiments provide an ophthalmic viewing system including an ophthalmic microscope, a gonioscopy device configured to relay images of an interior periphery of a patient's eye to the ophthalmic microscope, and a robotic arm configured to hold the gonioscopy device in a position in relation to the ophthalmic microscope and the patient's eye to relay the images of the interior periphery of the patient's eye to the ophthalmic microscope for viewing by a user.

Abstract: A system includes a display device and an actuated structure mounted to the display device and configured to move the display device in three-dimensional space. The system includes an imaging device configured to capture images of a patient's eye during an ophthalmic surgery and display the images on the display device. A controller is configured to activate the actuated structure to maintain visibility of the display device to a surgeon performing the ophthalmic surgery. The display may be positioned based on a surgeon profile and/or a treatment plan. Whether the display is visible may be determined based on images from a camera mounted to the imaging device, the display device, or elsewhere. Whether the display is visible may be determined based on kinematic data for the actuated structure and/or a support for the imaging device.

Abstract: A system for assisting a surgeon performing intraocular surgery on an eye of a medical patient includes a robotic arm and a tool assembly at a working end of the robotic arm. The tool assembly can include a proximal end mounted to the robotic arm's working end, a distal end, and a narrow elongate support member extending between the tool assembly's proximal and distal ends. A motion controller is operable to move the robotic arm to extend the distal end and at least a portion of the support member through an incision site in a surface of the patient's eye, thereby to locate a visualization element at the distal end of the tool member at a position inside the patient's eye.

Abstract: Disclosed herein are systems and methods for adjusting an intraocular lens (IOL) with optical coherence tomography (OCT) guidance. The IOL can comprise an optic portion and a plurality of haptics. In one embodiment, a method can comprise directing a laser beam generated by a laser system at a composite material making up part of the IOL. At least part of the composite material can expand in volume in response to the laser beam directed at the composite material. The method can also comprise measuring a volume change of the composite material or a change in at least part of the IOL by analyzing OCT images produced by an OCT imaging apparatus and determining a change in a base power of the IOL based on the measurements.

Abstract: Certain embodiments provide an intraocular lens (IOL) including a lens body having an anterior lens element and a posterior lens element, and an optical fluid in a cavity formed between the anterior lens element and the posterior lens element. The anterior lens element and the posterior lens element each comprise a lens material having a first Abbe number, and the optical fluid has a second Abbe number that is less than the first Abbe number.

Abstract: Certain embodiments provide an intraocular lens (IOL) including a lens body having a monolithic anterior lens element having an anterior nanostructure assembly formed thereon and a monolithic posterior lens element having a posterior nanostructure assembly formed thereon, and one or more haptics coupled to the lens body.

Abstract: Certain aspects provide an intraocular lens (IOL) including a monolithic lens body having an anterior nanostructure assembly on an anterior outer surface of the monolithic lens body and a posterior nanostructure assembly on a posterior outer surface of the monolithic lens body, and one or more haptics coupled to the monolithic lens body.

Abstract: The present invention is directed to a kit based on ARMS-PCR/AS-PCR in a single tube reaction for detection of mutations causing genetic disorders like hemoglobinopathies and musculopathies using unprocessed human dried blood spot.

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.

Abstract: Dermal filler hydrogel compositions, methods of making them, and methods of using them to treat soft tissue conditions, such as wrinkles, are provided. The compositions contain a crosslinked hyaluronic acid-based polymer and one or more additional ingredients, and are stable to sterilization by heat and/or pressure treatment. The additional ingredients include vasoconstrictive agents, antioxidant agents, such as a ascorbic acid agents, and/or anesthetic agents.

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.

Abstract: The current invention provides methods, as well as compositions useful in such methods, involving application of energy to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, as well as qualitative and/or quantitative detection of analytes that may be part of tissue constituents (e.g., several types of biomolecules, drugs, and microbes). Determination of tissue composition can be used in a variety of applications, including diagnosis or prognosis of local as well as systemic diseases, evaluating bioavailability of therapeutics in different tissues following drug administration, forensic detection of drugs-of-abuse, evaluating changes in the tissue microenvironment following exposure to a harmful agent, and various other applications.

Abstract: Disclosed are kits for at least partly liquefying tissue. The kit may include a liquefaction promoting medium (LPM). The LPM may include a non-ionic surfactant; a zwitterionic surfactant; and an abrasive material. The kit may include instructions. The instructions may direct a user to treat a tissue of a living subject by: applying the LPM together with the abrasive material to the tissue of the living subject; and transmitting energy to the tissue of the living subject through the abrasive material in the presence of the LPM effective to cause at least partial dissolution of one or more components of the tissue of the living subject.

Abstract: Dermal filler hydrogel compositions, methods of making them, and methods of using them to treat soft tissue conditions, such as wrinkles, are provided. The compositions contain a crosslinked hyaluronic acid-based polymer and one or more additional ingredients, and are stable to sterilization by heat and/or pressure treatment. The additional ingredients include vasoconstrictive agents, antioxidant agents, such as a ascorbic acid agents, and/or anesthetic agents.