Abstract: Exemplary embodiments of the present invention relate to a combination formulation for treatment or enhancing the therapy of liver disease, and more particularly, to a combination formulation prepared by containing colchicine and metformin as main active ingredients. The composition according to exemplary embodiments of the present invention may be used as an effective therapeutic agent for liver disease capable of treating and preventing liver fibrosis, liver cirrhosis, liver cancer, or hepatitis by reducing the amount of fat accumulated in the liver tissues by a synergistic effect of colchicine and metformin and lowering glucose tolerance and insulin tolerance and further, may be used as an excellent drug capable of replacing ursodeoxycholic acid.

Abstract: Exemplary embodiments of the present invention relate to a complex formulation for treating adipositas or improving a therapeutic effect, and more particularly, to a complex formulation prepared by including colchicine and metformin as main effective agents. According to exemplary embodiments of the present invention, the composition may be used as an excellent pharmaceutical composition capable of preventing or treating obesity by efficiently decomposing fat accumulated in the body by a synergic effect of colchicine and metformin.

Abstract: The present invention relates to a composition for preventing or treating liver diseases, and more particularly, provides a pharmaceutical composition for preventing or treating liver diseases containing colchicine and a dipeptidyl peptidase-4 (DPP-4) inhibitor as active ingredients. The pharmaceutical composition according to the present invention may significantly reduce liver injury such as fibrosis, fat accumulation, and inflammation in hepatocytes or liver tissues and more effectively prevent or treat liver diseases by co-using colchicine and a DPP-4 inhibitor, which are drugs used for treating other diseases in the related art.

Abstract: Exemplary embodiments of the present invention relate to a combination formulation for treatment or enhancing the therapy of liver disease, and more particularly, to a combination formulation prepared by containing colchicine and metformin as main active ingredients. The composition according to exemplary embodiments of the present invention may be used as an effective therapeutic agent for liver disease capable of treating and preventing liver fibrosis, liver cirrhosis, liver cancer, or hepatitis by reducing the amount of fat accumulated in the liver tissues by a synergistic effect of colchicine and metformin and lowering glucose tolerance and insulin tolerance and further, may be used as an excellent drug capable of replacing ursodeoxycholic acid.