Patents by Inventor Sun Ai Raillard
Sun Ai Raillard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8014961Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.Type: GrantFiled: February 21, 2007Date of Patent: September 6, 2011Assignee: Codexis Mayflower Holdings, LLCInventors: Steven H. Bass, Simon Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy S. Minshull, Mark Welch, Claus Gustafsson, Brian Carr, Stephan J. Jenne, Sun Ai Raillard, Andreas Crameri, Willem P. C. Stemmer, Robin Emig, Pascal Longchamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
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Patent number: 8008078Abstract: The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.Type: GrantFiled: April 23, 2008Date of Patent: August 30, 2011Assignees: Pfizer Inc., Pfizer Products Inc.Inventors: Kim J. Stutzman-Engwall, Anke Krebber, Claes Gustafsson, Jeremy S. Minshull, Sun Ai Raillard, Seran Kim, Yan Chen
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Patent number: 7858340Abstract: The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.Type: GrantFiled: June 11, 2003Date of Patent: December 28, 2010Assignees: Pfizer Inc., Pfizer Products Inc.Inventors: Kim J. Stutzman-Engwall, Yan Chen, Claes Gustafsson, Anke Krebber, Jeremy Minshull, Sun Ai Raillard
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Publication number: 20090017508Abstract: The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.Type: ApplicationFiled: April 23, 2008Publication date: January 15, 2009Inventors: Kim J. Stutzman-Engwall, Anke Krebber, Claes Gustafsson, Jeremy S. Minshull, Sun Ai Raillard, Seran Kim, Yan Chen
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Patent number: 7462469Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.Type: GrantFiled: May 23, 2002Date of Patent: December 9, 2008Assignee: Maxygen, Inc.Inventors: Steven H. Bass, S. Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claes Gustafsson, Brian Carr, Stephane Jenne, Sun Ai Raillard, Andreas Crameri, Willem P. C. Stemmer, Robin Emig, Pascal Longchamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
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Patent number: 7388085Abstract: The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.Type: GrantFiled: February 10, 2003Date of Patent: June 17, 2008Assignee: Pfizer IncInventors: Kim J. Stutzman-Engwall, Anke Krebber, Claes Gustafsson, Jeremy S. Minshull, Sun Ai Raillard, Seran Kim, Yan Chen
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Patent number: 7384387Abstract: Apparatus and methods for high throughput mass spectrometry are provided. The methods involve sample preparation in an off-line parallel purification system. Such methods include but are not limited to the use of an appropriate buffer when generating samples or the use of a solid support for tagged components. The samples prepared in this way do not then need to be column separated. The apparatus provided includes a cell growth plate for growing cells and generating products and/or reactants, an off-line parallel purification system, a mass spectrometer, and an automatic sampler that transports samples and injects them into the mass spectrometer of the apparatus. The methods and apparatus described are used, for example, in screening enzyme reaction pathways.Type: GrantFiled: February 11, 2000Date of Patent: June 10, 2008Assignee: Maxygen, Inc.Inventors: Sun Ai Raillard, Yong Hong Chen, Claus Krebber, Jeremy Minshull, Willem P. C. Stemmer
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Patent number: 6703240Abstract: The invention provides methods for generating, identifying, and selecting polynucleotides encoding novel starch metabolizing enzymes (NSME), NSME-encoding polynucleotides, compositions of recombinant shuffled NSME protein, plant cells and microbes containing a shuffled NSME polynucleotide in expressible form, plants containing a shuffled NSME polynucleotide in expressible form, novel starch compositions produced by plants and cells, uses of such plants, cells, and starch compositions.Type: GrantFiled: April 12, 2000Date of Patent: March 9, 2004Assignee: Maxygar, Inc.Inventors: Willem P. C. Stemmer, Venkitswaran Subramanian, Sun Ai Raillard, Gjalt Huisman
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Publication number: 20040009560Abstract: The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.Type: ApplicationFiled: June 11, 2003Publication date: January 15, 2004Applicant: Pfizer Inc.Inventors: Kim J. Stutzman-Engwall, Chen Yan, Claes Gustafsson, Anke Krebber, Jeremy Minshull, Sun Ai Raillard
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Publication number: 20030232415Abstract: The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.Type: ApplicationFiled: June 11, 2003Publication date: December 18, 2003Applicant: Pfizer Inc.Inventors: Kim J. Stutzman-Engwall, Yan Chen, Claes Gustafsson, Anke Krebber, Jeremy Minshull, Sun Ai Raillard
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Patent number: 6632673Abstract: The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.Type: GrantFiled: August 10, 2000Date of Patent: October 14, 2003Assignee: Pfizer, Inc.Inventors: Kim J. Stutzman-Engwall, Yan Chen, Claes Gustafsson, Anke Krebber, Jeremy Minshull, Sun Ai Raillard
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Publication number: 20030166165Abstract: The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.Type: ApplicationFiled: February 10, 2003Publication date: September 4, 2003Inventors: Kim J. Stutzman-Engwall, Anke Krebber, Claes Gustafsson, Jeremy S. Minshull, Sun Ai Raillard, Seran Kim, Yan Chen
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Publication number: 20030064393Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.Type: ApplicationFiled: May 23, 2002Publication date: April 3, 2003Applicant: Maxygen, Inc.Inventors: Steven H. Bass, S. Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claes Gustafsson, Brian Carr, Stephane Jenne, Sun Ai Raillard, Andreas Crameri, Willem P.C. Stemmer, Robin Emig, Pascal Longchamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
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Publication number: 20030054383Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.Type: ApplicationFiled: May 23, 2002Publication date: March 20, 2003Applicant: Maxygen, Inc.Inventors: Steven H. Bass, S. Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claes Gustafsson, Brian Carr, Stephane Jenne, Sun Ai Raillard, Andreas Crameri, Willem P.C. Stemmer, Robin Emig, Pascal Longschamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
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Publication number: 20030054384Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.Type: ApplicationFiled: May 23, 2002Publication date: March 20, 2003Applicant: Maxygen, Inc.Inventors: Steven H. Bass, S. Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claus Gustafsson, Brian Carr, Stephane Jenne, Sun Ai Raillard, Andreas Crameri, Willem P.C. Stemmer, Robin Emig, Pascal Longschamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
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Publication number: 20020155571Abstract: New triazine hydrolases, (both nucleic acids and proteins) are provided. Compositions which include these new proteins and/or genes, recombinant cells, shuffling methods involving the new triazine hydrolases, antibodies to the new triazine hydrolases and methods of using the triazine hydrolases are also provided.Type: ApplicationFiled: February 28, 2001Publication date: October 24, 2002Inventors: Sun Ai Raillard, Jeremy Minshull, Claes Gustafsson
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Publication number: 20020127623Abstract: Methods for sensing test stimuli using arrays of biopolymers are provided. Libraries of biopolymers, such nucleic acid variants, and expression products encoded by nucleic acid variants are provided. Reusable library arrays, and methods for their use are provided.Type: ApplicationFiled: July 31, 2001Publication date: September 12, 2002Applicant: Maxygen, Inc.Inventors: Jeremy Minshull, S. Christopher Davis, Mark Welch, Sun Ai Raillard, Kurt Vogel, Claus Krebber
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Publication number: 20020102577Abstract: Nucleotide incorporating enzyme variants having improved properties including the ability to utilize non-natural or rare nucleotide analogues in the synthesis of polynucleotides are provided. Methods for producing such nucleotide incorporating enzyme variants are provided, as are kits and integrated systems including the nucleotide incorporating enzyme variants.Type: ApplicationFiled: July 31, 2001Publication date: August 1, 2002Inventors: Sun Ai Raillard, Mark Welch, Jon Ness
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Publication number: 20010039014Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.Type: ApplicationFiled: January 10, 2001Publication date: November 8, 2001Applicant: Maxygen, Inc.Inventors: Steven H. Bass, S. Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claes Gustafsson, Brian Carr, Stephane Jenne, Sun Ai Raillard, Andreas Crameri, Willem P.C. Stemmer, Robin Emig, Pascal Longchamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter