Abstract: The present disclosure provides: a compound of a specific chemical structure, having excellent activity with respect to BTK degradation; or a pharmaceutically acceptable salt thereof. The present disclosure also provides a composition comprising the compound or pharmaceutically acceptable salts thereof. The present disclosure also provides are pharmaceutical use for treating or preventing BTK-associated diseases (for example, autoimmune diseases or cancer) of the compound, the salt thereof, and the composition comprising same according to the present disclosure. The present disclosure also provides a method for treating or preventing BTK-associated diseases (for example, autoimmune diseases or cancer), comprising administering, to a subject requiring treatment, an effective amount of the compound, the salt thereof, or the composition comprising same according to the present disclosure.

Abstract: Disclosed is a biological measurement device. The biological measurement device includes a first plate including a first transmission window; an electrode structure disposed on the first plate and spaced apart from the first window; a chamber plate disposed over the electrode structure and the first plate, the chamber plate including for exposing a portion of the electrode structure and the first transmission window; a second plate disposed over the chamber plate, the second plate including a second transmission window facing the first transmission window; a light emitting unit positioned either over the second transmission window and emitting light toward the second transmission window; and a light receiving unit disposed under the first transmission window and being configured to receive the light which the light emitting unit supplies to pass through the blood sample.

Abstract: A composition comprising an extract of combined herbs Acanthopanax koreanum Nakai and Crinum asiaticum var. japonicum showing treatment activity of a hair baldness disorder and stimulating activity of hair growth. The combined extract showed potent hair-growth promoting activity and a synergistic effect compared to each herb, i.e. the sole treatment of Acanthopanax koreanum Nakai or Crinum asiaticum var. japonicum, through animal model experiments, such as, the growth rate test using C57BL/6 mouse, to confirm the effect of the combined extract, i.e. combined treatment of Acanthopanax koreanum Nakai and Crinum asiaticum var. japonicum. Therefore the extract can be useful in treating a hair baldness disorder.

Abstract: The present invention relates to an agent apparatus and method for sharing anonymous identifier-based security information among security management domains. A plurality of security information sharing agent apparatuses respectively located in a plurality of security management domains and configured to collect security information and transmit collected security information to outside of the security management domains.

Abstract: The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.

Abstract: An apparatus for quantifying network threat situations includes a traffic analyzing unit to analyze packet patterns of traffics occurring on a target network being monitored to extract one or more suspicious domains. An IP monitoring unit gives security levels among a plurality of security levels to the suspicious domains according to the number of access IPs accessing the suspicious domains. An activity index computing unit computes activity indices for the suspicious domains from activity indices according to the access times to the suspicious domains of the access IPs. An attack amount anticipation unit analogizes an expected amount of attacks for each suspicious domain according to an expected amount of attacks for each zombie computer, the security level and the activity index of the suspicious domain.

Abstract: The present invention relates to an agent apparatus and method for sharing anonymous identifier-based security information among security management domains. A plurality of security information sharing agent apparatuses respectively located in a plurality of security management domains and configured to collect security information and transmit collected security information to outside of the security management domains.

Abstract: The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.

Abstract: Disclosed are a system for sharing information between heterogeneous service providers, including: a first service provider configured to generate first situation information based on an abnormal situation of a system; a second service provider configured to receive the first situation information from the first service provider, generate second situation information corresponding to the received first situation information; and the TTP configured to receive the first situation information from the first service provider, receive the second situation information from the second service provider, generate correspondence information based on the received information, and share the generated correspondence information.

Abstract: Disclosed are a cyber threat prior prediction apparatus, including a DNS based C&C server detecting unit configured to analyze DNS traffic to extract a domain address which is suspected as a C&C server; a network based abnormality detecting unit configured to analyze the network traffic to detect IP addresses of zombie PCs which access the C&C server and information of the zombie PCs; and a cyber threat predicting unit configured to predict a cyber threat situation based on the information of the zombie PCs.

Abstract: An apparatus for quantitatively evaluating security policy includes: a security policy analyzing unit for analyzing a security policy of a network; an evaluation criterion defining unit for defining an evaluation criterion for categorizing security features and evaluating each of the security features; an evaluation result calculating unit for calculating an evaluation result of each of security components based on the evaluation criterion; an indicator calculating unit for grouping the security components according to a security function and calculating an indicator by considering a security function of each group; and a quantitative evaluating unit for evaluating a security policy of the each group by using the indicator.

Abstract: The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.

Abstract: The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.

Abstract: Disclosed is a micro particle analyzing device illuminating light to fluid including micro particles, reading the lights emitted from the micro particles at a signal processing reading section and thus analyzing the micro particles. The device comprises a light source section emitting light which will be illuminated to the fluid; a lens regulating an amount and a focal distance of the light emitted from the light source; and a concave mirror condensing light emitted from the micro particle to reflect it to the reading section wherein the concave mirror is formed with a hole so that the light of the light source section having passed through the lens can pass through the concave mirror. When analyzing the micro particles using the analyzing device according to the invention, the amounts of lights emitted from the micro particles according to up-and-down positions of the micro particles are not different.

Abstract: Provided are a method and apparatus for providing a security mechanism guaranteeing transparency at a transport layer. The method includes: receiving a data packet from an application program, and searching key information corresponding to the data packet in key information database; determining whether to request a key exchange module of an application layer for a new key negotiation according to a result obtained by searching key information; and performing encrypting/decrypting based on key information when the key exchange module stores key negotiation information obtained by the new key negotiation in a kernel. The apparatus encrypts/decrypts the data packet at the transport layer of the kernel, thereby providing the application program with security transparency, effectively controlling and making it easily expansible.

Abstract: Disclosed is a micro particle analyzing device illuminating light to fluid including micro particles, reading the lights emitted from the micro particles at a signal processing reading section and thus analyzing the micro particles. The device comprises a light source section emitting light which will be illuminated to the fluid; a lens regulating an amount and a focal distance of the light emitted from the light source; and a concave mirror condensing light emitted from the micro particle to reflect it to the reading section wherein the concave mirror is formed with a hole so that the light of the light source section having passed through the lens can pass through the concave mirror. When analyzing the micro particles using the analyzing device according to the invention, the amounts of lights emitted from the micro particles according to up-and-down positions of the micro particles are not different.