Abstract: The present invention relates to an antigen-binding molecule comprising a heavy chain variable region comprising a heavy-chain complementarity-determining region 1 (HCDR1) comprising an amino acid sequence represented by Sequence No. 1, an HCDR2 comprising an amino acid sequence represented by Sequence No. 2, and an HCDR3 comprising an amino acid sequence represented by Sequence No. 3; a light-chain variable region comprising a light-chain complementarity-determining region 1 (LCDR1) comprising an amino acid sequence represented by Sequence No. 4, an LCDR2 comprising an amino acid sequence represented by Sequence No. 5, and an LCDR3 comprising an amino acid sequence represented by Sequence No. 6; wherein the antigen-binding molecule is a T cell receptor (TCR); and to a cell line expressing the same.

Abstract: The present invention relates to process for the preparing of optically active ester derivatives and their acid derivatives which are used intensively as important chiral intermediates from racemic ?-hydroxybutyl ester derivatives. In more detail, this invention relates to the process for preparing optically active ?-hydroxybutyl ester derivatives and their acid derivatives by stereospecific hydrolysis of racemic ?-hydroxybutyl ester derivatives using Upases or lipase-producing microorganisms in the aqueous phase or organic phase including aqueous solvent. The method of making optically active ester derivatives and their acid derivatives by hydrolysis of ?-hydroxybutyl ester derivatives represented by the general formula 1 in scheme 1 is easier and more economical comparing to the conventional methods and the products have high optical purity. Also separation of ester derivatives from acid derivatives is easy after reaction. Thus this method is a useful process on the industrial scale.

Abstract: The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 in scheme 1. In more detail, this invention relates to the process for the preparation of optically active alcohols and their esters which are used as pharmaceutical intermediates by reacting the hydroxyl group stereospecifically by lipase after adding racemic alcohols represented by the general formula 1 and succinic anhydride as an acylating agent to the organic solvent. According to this invention, the primary hydroxyl group of 1,2-diols is transformed by other functional group and the secondary hydroxyl group is esterified stereospecifically with succinic anhydride as an acylating agent.

Abstract: The present invention relates to an apparatus and method for automatically defibering and extracting kraft pulp from old corrugated cardboards. The apparatus includes a) a pulper (1) for crushing, separating and defibering old corrugated cardboards using white water; b) a first means for continuously detecting defibering states of old corrugated cardboard pieces and outputting detected data; c) a second means for selectively exhausting defibered corrugated medium and linerboard from the pulper; d) a third means for respectively estimating first and second target values indicative of defibering states of corrugated medium and linerboard pieces defibered in the pulper (1); and a fourth means for controlling the second means to exhaust defibered corrugated medium and linerboard from the pulper (1) by comparing the detected data with the estimated first and second target values respectively.

Abstract: A process for producing new corrugated containerboard from old corrugated container (OCC) without using expensive virgin UKP includes three new steps. These steps are separating corrugated medium from OCC before pulping linerboard, removing micro-fibrils from defibered linerboard furnish, and minimizing the loss of long fibers through reject streams of fine screens.

Abstract: A process for the manufacture of recycled paper having improved strength properties is achieved by replacing refiners by agitators, modifying extractor, applying effective amount of dispersion aids, and applying appropriate amount of dry strength additives.