Abstract: The present disclosure is related to a perfusable-type bio-dual proximal tubule cell construct and a producing method thereof capable of applying an in vitro artificial organ model configured to include a first bioink comprising a decellularized substance derived from a mammalian kidney tissue and human umbilical vascular endothelial cells (HUVECs) and a second bioink comprising the decellularized substance and renal proximal tubular epithelial cells (RPTECs), wherein the first bioink and the second bioink are coaxial and printed in tubular constructs having different inner diameters. According to the present disclosure, it is possible to use the renal proximal tubule-on-a-chip as a bioreactor capable of observing a biological drug reaction similar to a real drug by perfusing various drugs to the renal proximal tubule-on-a-chip.

Abstract: An improved fishing rod holding and supporting device including a V-shaped stand member having a pointed tip, a hinge, and a T-shaped anchor, and a tubular receiver having an opening for slidably receiving a fishing rod. The device can be tightly fixed to the ground by the pointed tip or optionally to the deck by the T-shaped anchor.

Abstract: This invention is a sports shoe protector having a sole and a means for securing the sole to a sports shoe having spikes. The sole includes at least one U-shaped shoulder extending from a peripheral portion of the base of the sole to provide peripheral support to the shoe and to provide an open area for receiving shoe spikes. An inner support extending from the base and positioned within the mouth of the U-shaped shoulder can be used to provide additional support and to form, in combination with the U-shaped shoulder, an open channel area for receiving shoe spikes.

Abstract: In one aspect, compounds capable of inhibiting an endopeptidase responsible for a degradation pathway of enkephalin and having the general formulaA--B--NHOHwherein A is one of the aromatic group-containing amino acid residues L-tryptophyl, D-tryptophyl, L-tyrosyl, D-tyrosyl, L-phenylalanyl, or D-phenylalanyl, and B is one of the amino acids glycine, L-alanine, D-alanine, L-leucine, D-leucine, L-isoleucine, or D-isoleucine; or a pharmaceutically acceptable salt thereof.