Abstract: The present invention relates to 2-hydroxy-alkylamino-benzoic acid derivatives and to a combination of cell necrosis inhibitor and lithium, process for the preparation of the derivatives or the combination, pharmaceutical formulation containing the derivatives or the combination, and use of the derivatives or the combination by either concomitant or sequential administration for improvement of treatment of neuronal death or neurological dysfunction. The derivatives and the combination of the present invention are useful for treating neurological diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), spinal muscular atrophy, Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, traumatic brain injury or spinal cord injury; and for treating ocular diseases such as glaucoma, diabetic retinopathy or macular degeneration.

Abstract: A device for holding a roll of material surrounding a core includes a mount with two arms, each having a retractable catch. The retractable catch includes a contoured end, optionally substantially hemispheric, that transmits a radial force on the core to cause the catch to retract. In an optional embodiment, the catch is part of a catch assembly including a spring biasing the catch perpendicular to the arms and toward the core and an annular retainer that holds the catch to the arms.

Abstract: A toilet tissue holder for easy engaging and disengaging a bathroom tissue roll is comprised of; a “” shape arm, wherein two shallow cylindrical tubes having male grooves out side of the tube wall are developed facing each other at the end of both arms; two wound springs placed inside of each shallow tube; two hemisphere tissue roll holders placed over each spring; and two cylindrical caps having female groove inside wall thereof. It is very easy to engage and disengage a toilet tissue role even with one hand.