Patents by Inventor Sunao Takeda
Sunao Takeda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9970872Abstract: A cell analyzer includes: a measuring portion which measures cells that are nuclear stained; a displaying portion which displays a histogram of a fluorescence intensity by using a result of the measurement by the measuring portion; and a determining unit which obtains a number of strong-area cells that are distributed in an area where the fluorescence intensity is stronger than normal cells, and which determines a malignancy grade of cancer based on the number of strong-area cells and the histogram.Type: GrantFiled: August 25, 2011Date of Patent: May 15, 2018Assignee: Nihon Kohden CorporationInventors: Takahiro Shioyama, Akane Suzuki, Sunao Takeda
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Patent number: 9783773Abstract: A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of the sterile space and an outside of the sterile space communicate with each other, the delivery flow path configured to limit a flow in the delivery flow path to a direction that is directed from the inside of the sterile space toward the outside of the sterile space; and a culture solution delivering section configured to deliver the sampled culture solution to the outside of the sterile space via the delivery flow path.Type: GrantFiled: March 28, 2012Date of Patent: October 10, 2017Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITYInventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda
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Patent number: 9658214Abstract: A method of analyzing cells, the method comprising: measuring a number of cells which are nuclear stained, in a to-be-determined tissue, and acquiring a histogram showing a fluorescence intensity based on a result of the measurement; analyzing the histogram, and acquiring data of predetermined parameters; comparing the data of the parameters with first thresholds predetermined for the parameters, to perform a first cancer determination for each of the parameters on the to-be-determined tissue; performing a scoring process for each of the parameters, on a result of the first cancer determination for each of the parameters, to calculate scores of the parameters; and combining the scores of the parameters with one another, thereby performing a second cancer determination on the to-be-determined tissue.Type: GrantFiled: July 19, 2013Date of Patent: May 23, 2017Assignee: NIHON KOHDEN CORPORATIONInventors: Takahiro Shioyama, Akane Suzuki, Hirotsugu Kubo, Sunao Takeda
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Patent number: 9448228Abstract: A cell analyzing apparatus includes: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer, and which is configured to determine existence/nonexistence of cancer cells based on a result of the frequency analysis.Type: GrantFiled: June 13, 2013Date of Patent: September 20, 2016Assignee: NIHON KOHDEN CORPORATIONInventors: Sunao Takeda, Takahiro Shioyama, Akane Suzuki, Yo Kato, Nae Hinata
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Patent number: 9443127Abstract: A cell analyzing apparatus includes: a first histogram acquiring section which is configured to acquire a first histogram of fluorescence intensities by using a result of a measurement of a number of nuclear stained cells; a second histogram acquiring section which is configured to acquire a second histogram that is normalized based on a fluorescence intensity value indicating a maximum value of the first histogram; a determining section which is configured to determine whether cancer cells exist or not, based on one of the first histogram and the second histogram; and an outputting section which is configured to output a result of the determination performed by the determining section.Type: GrantFiled: September 17, 2014Date of Patent: September 13, 2016Assignee: Nihon Kohden CorporationInventors: Sunao Takeda, Hirotsugu Kubo, Takahiro Shioyama, Akane Suzuki, Kenichi Nomura, Yo Kato, Nae Hinata
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Patent number: 9304088Abstract: A method of measuring a pH of a solution includes: emitting light beams of two wavelengths from one side of a measuring region of a solution into which an indicator is mixed, while pulsating the solution in the measuring region; receiving at least one of transmitted light beams and reflected light beams of the emitted light beams on the other side of the measuring region, while pulsating the solution in the measuring region; obtaining absorbances of the two wavelengths based on the received at least one of the transmitted light beams and the reflected light beams; obtaining an absorbance ratio from the obtained absorbances; and calculating a pH value of the solution based on the obtained absorbance ratio and an absorbance ratio/pH value correspondence database which is previously stored.Type: GrantFiled: February 19, 2012Date of Patent: April 5, 2016Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITYInventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda, Shinji Yamamori
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Patent number: 9291572Abstract: A pH measuring method includes: illuminating a medium solution, which includes: a first material; and a second material, with a plurality of light beams, which includes: a first light beam, a wavelength of which corresponds to a first absorption peak; a second light beam, a wavelength of which corresponds to a second absorption peak or a second convergence point; a third light beam, a wavelength of which corresponds to a third absorption peak or a third convergence point; and a fourth light beam, a wavelength of the fourth light beam at which an absorbance of at least one of the first and second materials is converged irrespective of a pH; receiving transmitted or reflected light beams of the first to fourth light beams; measuring absorbances at the wavelengths of the received light beams respectively; and calculating a pH of the medium solution based on the absorbances.Type: GrantFiled: April 6, 2012Date of Patent: March 22, 2016Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITYInventors: Mitsuhiro Oura, Hirotsugu Kubo, Sunao Takeda, Teruo Okano, Tatsuya Shimizu
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Patent number: 9017368Abstract: A method of calculating a blood pressure, includes: providing a non-invasive blood pressure measurement apparatus which includes a cuff being inflatable and deflatable and adapted to be fitted on a part of a living body and in which a plurality of calculation methods each of which has priority in accordance with a type of noise information are set; detecting, by the cuff, a signal waveform representing a change in an oscillation amplitude and a change in a cuff pressure; determining the type of the noise information contained in the detected signal waveform; deciding the blood pressure from at least one candidate value for the blood pressure, which is calculated by one of the calculation methods that has the priority with respect to the determined type of the noise information; and displaying the decided blood pressure.Type: GrantFiled: October 31, 2008Date of Patent: April 28, 2015Assignee: Nihon Kohden CorporationInventors: Takashi Usuda, Sunao Takeda
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Publication number: 20150078649Abstract: A cell analyzing apparatus includes: a first histogram acquiring section which is configured to acquire a first histogram of fluorescence intensities by using a result of a measurement of a number of nuclear stained cells; a second histogram acquiring section which is configured to acquire a second histogram that is normalized based on a fluorescence intensity value indicating a maximum value of the first histogram; a determining section which is configured to determine whether cancer cells exist or not, based on one of the first histogram and the second histogram; and an outputting section which is configured to output a result of the determination performed by the determining section.Type: ApplicationFiled: September 17, 2014Publication date: March 19, 2015Applicant: Nihon Kohden CorporationInventors: Sunao TAKEDA, Hirotsugu KUBO, Takahiro SHIOYAMA, Akane SUZUKI, Kenichi NOMURA, Yo KATO, Nae HINATA
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Patent number: 8882012Abstract: A cell isolation apparatus includes: a chamber body which includes a chamber into which tissue is to be introduced; an isolation member which is moved in the chamber and which is to collide with the tissue to isolate a cell; and a controlling portion which controls an operation of the isolation member in the chamber body.Type: GrantFiled: August 25, 2011Date of Patent: November 11, 2014Assignees: Nihon Kohden Corporation, Tokyo Women's Medical UniversityInventors: Yuji Haraguchi, Tatsuya Shimizu, Teruo Okano, Takahiro Shioyama, Akane Suzuki, Sunao Takeda
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Patent number: 8649837Abstract: In order to measure a pulse rate and an oxygen saturation of a subject who is in an exercised state, each of two pulse wave signals obtained from the subject is separated into a signal component and a noise component. A frequency spectrum of the signal component and a frequency spectrum of the noise component are obtained. It is judged whether a body motion of the subject is occurred based on the frequency spectrum of the signal component and the frequency spectrum of the noise component. A pulsation frequency is determined based on the judgment as to the body motion. The pulse rate is calculated based on the pulsation frequency. The oxygen saturation is calculated based on a ratio of spectra of the two pulse wave signals corresponding to the pulsation frequency.Type: GrantFiled: July 17, 2008Date of Patent: February 11, 2014Assignee: Nihon Kohden CorporationInventors: Yoshihiro Sugo, Naoki Kobayashi, Sunao Takeda
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Publication number: 20140030728Abstract: A method of analyzing cells, the method comprising: measuring a number of cells which are nuclear stained, in a to-be-determined tissue, and acquiring a histogram showing a fluorescence intensity based on a result of the measurement; analyzing the histogram, and acquiring data of predetermined parameters; comparing the data of the parameters with first thresholds predetermined for the parameters, to perform a first cancer determination for each of the parameters on the to-be-determined tissue; performing a scoring process for each of the parameters, on a result of the first cancer determination for each of the parameters, to calculate scores of the parameters; and combining the scores of the parameters with one another, thereby performing a second cancer determination on the to-be-determined tissue.Type: ApplicationFiled: July 19, 2013Publication date: January 30, 2014Applicant: NIHON KOHDEN CORPORATIONInventors: Takahiro Shioyama, Akane Suzuki, Hirotsugu Kubo, Sunao Takeda
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Publication number: 20140031710Abstract: An apparatus for determining sleep apnea includes: an expiratory gas collector which is configured to collect an expiratory gas of a subject; an analyzer which is configured to analyze a constituent and a concentration of the constituent in the collected expiratory gas; and a determiner which is configured to determine whether the subject is in sleep apnea or not, based on a concentration of at least VOC in the analyzed expiratory gas.Type: ApplicationFiled: March 7, 2013Publication date: January 30, 2014Applicants: NIHON KOHDEN CORPORATION, TOKAI UNIVERSITY EDUCATIONAL SYSTEM, WASEDA UNIVERSITYInventors: Muneshige KURAHASHI, Naofumi Kobayashi, Sunao Takeda, Takashi Nagaoka, Tadashi Abe, Tetsuya Urano, Takuya Aoki, Chizuko Tsuji
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Publication number: 20130337501Abstract: A cell analyzing apparatus includes: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer, and which is configured to determine existence/nonexistence of cancer cells based on a result of the frequency analysis.Type: ApplicationFiled: June 13, 2013Publication date: December 19, 2013Inventors: Sunao Takeda, Takahiro Shioyama, Akane Suzuki, Yo Kato, Nae Hinata
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Patent number: 8420028Abstract: A cell isolation apparatus includes: a cylinder member that is inserted into a container into which a reagent is to be introduced; a net which is stretched over the cylinder member; a tissue acquiring unit that is projected from the cylinder member; and a bottom lid portion that is configured by a bottomed pipe in which a first hole that communicates an interior with an exterior is formed, and that is fitted to a bottom portion of the cylinder member in a state where the net and the tissue acquiring unit are accommodated.Type: GrantFiled: August 22, 2011Date of Patent: April 16, 2013Assignee: Nihon Kohden CorporationInventors: Akane Suzuki, Takahiro Shioyama, Sunao Takeda
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Publication number: 20120252110Abstract: A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of the sterile space and an outside of the sterile space communicate with each other, the delivery flow path configured to limit a flow in the delivery flow path to a direction that is directed from the inside of the sterile space toward the outside of the sterile space; and a culture solution delivering section configured to deliver the sampled culture solution to the outside of the sterile space via the delivery flow path.Type: ApplicationFiled: March 28, 2012Publication date: October 4, 2012Applicants: Tokyo Women's Medical University, Nihon Kohden CorporationInventors: Mitsuhiro OURA, Teruo OKANO, Tatsuya SHIMIZU, Hirotsugu KUBO, Sunao TAKEDA
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Publication number: 20120253692Abstract: A pH measuring method includes: illuminating a medium solution, which includes: a first material; and a second material, with a plurality of light beams, which includes: a first light beam, a wavelength of which corresponds to a first absorption peak; a second light beam, a wavelength of which corresponds to a second absorption peak or a second convergence point; a third light beam, a wavelength of which corresponds to a third absorption peak or a third convergence point; and a fourth light beam, a wavelength of the fourth light beam at which an absorbance of at least one of the first and second materials is converged irrespective of a pH; receiving transmitted or reflected light beams of the first to fourth light beams; measuring absorbances at the wavelengths of the received light beams respectively; and calculating a pH of the medium solution based on the absorbances.Type: ApplicationFiled: April 6, 2012Publication date: October 4, 2012Inventors: Mitsuhiro OURA, Hirotsugu Kubo, Sunao Takeda, Teruo Okano, Tatsuya Shimizu
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Publication number: 20120214250Abstract: A method of measuring a pH of a solution includes: emitting light beams of two wavelengths from one side of a measuring region of a solution into which an indicator is mixed, while pulsating the solution in the measuring region; receiving at least one of transmitted light beams and reflected light beams of the emitted light beams on the other side of the measuring region, while pulsating the solution in the measuring region; obtaining absorbances of the two wavelengths based on the received at least one of the transmitted light beams and the reflected light beams; obtaining an absorbance ratio from the obtained absorbances ; and calculating a pH value of the solution based on the obtained absorbance ratio and an absorbance ratio/pH value correspondence database which is previously stored.Type: ApplicationFiled: February 19, 2012Publication date: August 23, 2012Applicants: Tokyo Women's Medical University, Nihon Kohden CorporationInventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda, Shinji Yamamori
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Publication number: 20120214225Abstract: A cell incubator includes: a culture cell accommodating section which accommodates cells to be cultured and a culture solution; and an RFID tag which is attached to the culture cell accommodating section and which is configured to transmit predetermined information to a communicating apparatus in response to reception of a signal that is wirelessly transmitted from the communicating apparatus.Type: ApplicationFiled: February 19, 2012Publication date: August 23, 2012Applicants: Tokyo Women's Medical Uuniversity, Nihon Kohden CorporationInventors: Mitsuhiro OURA, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Katsuyoshi Suzuki, Sunao Takeda
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Publication number: 20120052559Abstract: A cell isolation apparatus includes: a chamber body which includes a chamber into which tissue is to be introduced; an isolation member which is moved in the chamber and which is to collide with the tissue to isolate a cell; and a controlling portion which controls an operation of the isolation member in the chamber body.Type: ApplicationFiled: August 25, 2011Publication date: March 1, 2012Applicants: TOKYO WOMEN'S MEDICAL UNIVERSITY, NIHON KOHDEN CORPORATIONInventors: Yuji HARAGUCHI, Tatsuya SHIMIZU, Teruo OKANO, Takahiro SHIOYAMA, Akane SUZUKI, Sunao TAKEDA