Patents by Inventor Sundaramoorthi Swaminathan

Sundaramoorthi Swaminathan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphonate compounds having immuno-modulatory activity
    Patent number: 7470724
    Abstract: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: December 30, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Alan X. Huang, Thorsten Kirschberg, Christopher P. Lee, Richard L. Mackman, Peter H. Nelson, Hyung-Jung Pyun, Adrian S. Ray, William J. Watkins, Jennifer R. Zhang, Sundaramoorthi Swaminathan
  • Anti-cancer phosphonate analogs
    Patent number: 7452901
    Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: November 18, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Constantine G. Boojamra, Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Alan X. Huang, Choung U. Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher P. Lee, Kuei-Ying Lin, Richard L. Mackman, David Y. Markevitch, Peter H. Nelson, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang, Lijun Zhang
  • Anti-inflammatory phosphonate compounds
    Patent number: 7432261
    Abstract: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: October 7, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Craig Gibbs, Ralph F. Hirschmann, Thorsten Kirschberg, Christopher P. Lee, Kuei-Ying Lin, Richard L. Mackman, Peter H. Nelson, David A. Oare, Hyung-Jung Pyun, Adrian S. Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang
  • Antiviral phosphonate analogs
    Patent number: 7429565
    Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: September 30, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Constantine G. Boojamra, Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Haolun Jin, Ralph F. Hirschmann, Alan X. Huang, Choung U. Kim, Thorsten Kirschberg, Christopher P. Lee, William A. Lee, Richard L. Mackman, David Y. Markevitch, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang
  • Purine nucleoside phosphorylase inhibitory phosphonate compounds
    Patent number: 7427624
    Abstract: The invention is related to phosphorus substituted purine nucleoside phosphorylase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: September 23, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Thorsten Kirschberg, Adrian S. Ray, Sundaramoorthi Swaminathan, William J. Watkins
  • Kinase inhibitory phosphonate analogs
    Patent number: 7417055
    Abstract: The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: August 26, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Thorsten Kirschberg, Richard L. Mackman, Sundaramoorthi Swaminathan, William J. Watkins
  • Phosphonate inhibitors of HCV
    Publication number: 20080107628
    Abstract: A compound of Formula I, Formula II, Formula III, or Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, therapeutic compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
    Type: Application
    Filed: July 6, 2007
    Publication date: May 8, 2008
    Inventors: Constantine Boojamra, James Chen, Alan Huang, Choung Kim, Kuei-Ying Lin, Richard Mackman, David Oare, Jason Perry, Oliver Saunders, Sundaramoorthi Swaminathan, Lijun Zhang
  • Therapeutic compounds and methods
    Publication number: 20080070910
    Abstract: The present invention provides compounds of Formula (I): wherein A, X, Q, R2-R6, m, and W have the values described herein, as well as compositions comprising such compounds. The compounds are protease inhibitors and are useful for inhibiting the development of drug resistance in animals.
    Type: Application
    Filed: July 24, 2007
    Publication date: March 20, 2008
    Inventors: Manoj Desai, Christopher Lee, Hongtao Liu, Sundaramoorthi Swaminathan, Lianhong Xu
  • Method and compositions for identifying anti-hiv therapeutic compounds
    Publication number: 20070190523
    Abstract: The invention relates to methods and compositions for identifying compounds having therapeutic activity against human immunodeficiency virus (HIV).
    Type: Application
    Filed: November 6, 2003
    Publication date: August 16, 2007
    Inventors: Gabriel Birkus, James Chen, Xiaowu Chen, Tomas Cihlar, Eugene Eisenberg, Marcos Hatada, Gong-Xin He, Choung Kim, William Lee, Martin McDermott, Sundaramoorthi Swaminathan
  • Purine nucleoside phosphorylase inhibitory phosphonate compounds
    Publication number: 20070027113
    Abstract: The invention is related to phosphorus substituted purine nucleoside phosphorylase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: February 1, 2007
    Inventors: James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Thorsten Kirschberg, Adrian Ray, Sundaramoorthi Swaminathan, William Watkins
  • Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
    Publication number: 20070010489
    Abstract: Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
    Type: Application
    Filed: April 25, 2003
    Publication date: January 11, 2007
    Inventors: Murty Arimilli, Mark Becker, Clifford Bryant, James Chen, Xiaowu Chen, Azar Dastgah, Maria Fardis, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard Mackman, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Wiliams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Therapeutic phosphonate compounds
    Publication number: 20060264404
    Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
    Type: Application
    Filed: October 25, 2005
    Publication date: November 23, 2006
    Inventors: Constantine Boojamra, Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Manoj Desai, Maria Fardis, Craig Gibbs, Ralph Hirschmann, Alan Huang, Haolun Jin, Choung Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher Lee, William Lee, Kuei-Ying Lin, Richard Mackman, David Markevitch, Peter Nelson, David Oare, Vidya Prasad, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang, Lijun Zhang
  • Anti-inflammatory phosphonate compounds
    Publication number: 20060199788
    Abstract: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: September 7, 2006
    Inventors: Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Craig Gibbs, Ralph Hirschmann, Thorsten Kirschberg, Christopher Lee, Kuei-Ying Lin, Richard Mackman, Peter Nelson, David Oare, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang
  • Method and compositions for identifying anti-hiv therapeutic compounds
    Publication number: 20060115815
    Abstract: Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
    Type: Application
    Filed: April 25, 2003
    Publication date: June 1, 2006
    Inventors: Gabriel Birkus, James Chen, Xiaowu Chen, Tomas Cihlar, Eugene Eisenberg, Marcos Hatada, Gong-Xi He, Choung Kim, William Lee, Martin McDermott, Sundaramoorthi Swaminathan
  • Anti-cancer phosphonate analogs
    Publication number: 20060079478
    Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: April 13, 2006
    Inventors: Constantine Boojamra, Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Alan Huang, Choung Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher Lee, Kuei-Ying Lin, Richard Mackman, David Markevitch, Peter Nelson, David Oare, Vidya Prasad, Hyung-Jung Pyun, Adrian Ray, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang, Lijun Zhang
  • Phosphonate compounds having immuno-modulatory activity
    Publication number: 20060035866
    Abstract: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: February 16, 2006
    Inventors: Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Manoj Desai, Maria Fardis, Alan Huang, Thorsten Kirschberg, Christopher Lee, Richard Mackman, Peter Nelson, Hyung-Jung Pyun, Adrian Ray, William Watkins, Jennifer Zhang, Sundaramoorthi Swaminathan
  • Kinase inhibitory phosphonate analogs
    Publication number: 20050261253
    Abstract: The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: November 24, 2005
    Inventors: Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Manoj Desai, Maria Fardis, Thorsten Kirschberg, Richard Mackman, Sundaramoorthi Swaminathan, William Watkins
  • Nucleoside phosphonate analogs
    Publication number: 20050261237
    Abstract: The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: November 24, 2005
    Inventors: Constantine Boojamra, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Alan Huang, Choung Kim, Thorsten Kirschberg, Christopher Lee, David Oare, Vidya Prasad, Adrian Ray, Sundaramoorthi Swaminathan, William Watkins
  • Method and compositions for identifying anti-HIV therapeutic compounds
    Publication number: 20050239054
    Abstract: Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
    Type: Application
    Filed: December 22, 2003
    Publication date: October 27, 2005
    Inventors: Murty Arimilli, Mark Becker, Gabriel Birkus, Clifford Bryant, James Chen, Xiaowu Chen, Tomas Cihlar, Azar Dastgah, Eugene Eisenberg, Maria Fardis, Marcos Hatada, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard MacKman, Martin McDermott, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Williams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Antiviral phosphonate analogs
    Publication number: 20050215513
    Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: September 29, 2005
    Inventors: Constantine Boojamra, Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Haolun Jin, Ralph Hirschmann, Alan Huang, Choung Kim, Thorsten Kirschberg, Christopher Lee, William Lee, Richard MacKman, David Markevitch, David Oare, Vidya Prasad, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang